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Gene · 133396

IL31RA: interleukin 31 receptor A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IL31RA: interleukin 31 receptor A. Genes, record 133396. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/133396

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Gene

Symbol
IL31RA
HGNC
Name
interleukin 31 receptor A
HGNC
NCBI Gene ID
133396
NCBI Gene
HGNC ID
HGNC:18969
HGNC
Ensembl
ENSG00000164509
NCBI Gene
Aliases
CRL, CRL3, GLM-R, GLMR, GPL, Glmr, IL-31RA, PLCA2, PRO21384, hGLM-R, zcytoR17
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8NI17Interleukin-31 receptor subunit alpha7321Ensembl, GeneID, HGNC

Source UniProt

Patents71

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1967434Q8NI17Espacenet
EP 4644424 A22025-11-052Q8NI17Espacenet
EP 4633648 A12025-10-2242Q8NI17Espacenet
JP 2025530773 A2025-09-172Q8NI17Espacenet
JP 2025529142 A2025-09-042099Q8NI17Espacenet
JP 2025529142 A2025-09-046733Q8NI17Espacenet
US 12371689 B22025-07-292099Q8NI17Espacenet
US 12371689 B22025-07-296733Q8NI17Espacenet
JP 2025517970 A2025-06-1267434Q8NI17Espacenet
EP 4547223 A22025-05-0720Q8NI17Espacenet

1 to 10 of 71

See all 71 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
NEMOLIZUMABCHEMBL4297794Interleukin-31 receptor subunit alpha inhibitorINHIBITOR

Source ChEMBL

Trials18

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07074977NEMOLIZUMABPHASE2ClinicalTrials.gov
NCT07047690NEMOLIZUMABPHASE2ClinicalTrials.gov
NCT05214794NEMOLIZUMABPHASE22026-02-13ClinicalTrials.gov
NCT05075408NEMOLIZUMABPHASE2/PHASE32025-02-20ClinicalTrials.gov
NCT05056779NEMOLIZUMABPHASE3ClinicalTrials.gov
NCT05052983NEMOLIZUMABPHASE32024-10-08ClinicalTrials.gov
NCT04921345NEMOLIZUMABPHASE2ClinicalTrials.gov
NCT04501679NEMOLIZUMABPHASE32024-07-10ClinicalTrials.gov
NCT04501666NEMOLIZUMABPHASE32024-07-10ClinicalTrials.gov
NCT04204616NEMOLIZUMABPHASE3ClinicalTrials.gov

1 to 10 of 18

See all 18 trials

NIH grants1,599

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIL31RA papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)272025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control122025
P30CA008748Cancer Center Support Grant82025
P30CA016087Cancer Center Support Grant62025
UL1TR001863Yale Clinical and Translational Science Award62025
ZIAAI005022Antibody Neutralization Mechanisms62025
P30CA016672Cancer Center Support Grant52025
P30CA044579University of Virginia Cancer Center Support Grant52025
R35GM136250Regulation of cell proliferation by CRL ubiquitin ligases52025
P30AI027763UCSF-Bay Area Center for AIDS Research42025

1 to 10 of 1,599Source NIH's project files

See all 1,599 nih grants

Papers2,998

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Off-Label Uses of Nemolizumab: A Narrative Review.J Drugs Dermatol202642826149PubTator, text miningPubMed
Rapid Improvement of Refractory Pruritus in Extragenital and Perianal Lichen Sclerosus With Nemolizumab: A Case Report.Cureus202642799185PubTator, text miningPubMed
SPOP-mediated ZMYND8 ubiquitination and phase separation exclusion drives mTOR inhibitor resistance in kidney cancer.Nat Commun202642778578PubTator, text miningPubMed
Decoding MOF-Enzyme-Substrate Compatibility for Universal Biocatalyst Immobilization.ACS Appl Mater Interfaces202642742227PubTator, text miningPubMed
: Interleukin-31 in Atopic Dermatitis and Prurigo Nodularis: Pathophysiology, Neuroimmune Mechanisms, and Clinical Efficacy of Nemolizumab.J Drugs Dermatol202642696343PubTator, text miningPubMed
Tape Strip Transcriptomics Reveal Nemolizumab Effects on Pruritus, Hyperplasia, Inflammation, and Extracellular Matrix Markers in Patients With Moderate-to-Severe Atopic Dermatitis.Allergy202642693785PubTator, text miningPubMed
Autosomal recessive OSMRβ deficiency: Connecting OSM and/or IL-31 with atopy.J Hum Immun202642639505PubTator, text miningPubMed
Cryo-EM structure of the interleukin-31 receptor complex defines non-canonical interactions that confer receptor specificity.J Biol Chem202642637078PubTator, text miningPubMed
Impact of IL31RA Genetic Variants and Expression on Metastatic Progression in Oral Cavity Squamous Cell Carcinoma.Oncol Res202642630481PubTator, text miningPubMed
Beyond Histamine: Mast Cell-Neuron Communication in Chronic Pruritic and Pain Disorders.Exp Dermatol202642619475PubTator, text miningPubMed

1 to 10 of 2,998

See all 2,998 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/133396

GET https://conductscience.org/api/genes/v1/133396/patents?page=2