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Gene · 156

GRK2: G protein-coupled receptor kinase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GRK2: G protein-coupled receptor kinase 2. Genes, record 156. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/156

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Gene

Symbol
GRK2
HGNC
Name
G protein-coupled receptor kinase 2
HGNC
NCBI Gene ID
156
NCBI Gene
HGNC ID
HGNC:289
HGNC
Ensembl
ENSG00000173020
NCBI Gene
Aliases
ADRBK1, BARK1, BETA-ARK1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P25098G protein-coupled receptor kinase 268920Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436848P25098Espacenet
EP 4650780 A22025-11-194817P25098Espacenet
EP 4641201 A22025-10-294391P25098Espacenet
JP 2025154589 A2025-10-109P25098Espacenet
JP 2025154616 A2025-10-109P25098Espacenet
JP 2025517969 A2025-06-124391P25098Espacenet
JP 2025517970 A2025-06-124817P25098Espacenet
JP 2025062604 A2025-04-143451P25098Espacenet
JP 2023123507 A2023-09-05227P25098Espacenet
JP 2023527559 A2023-06-292P25098Espacenet

1 to 10 of 45

See all 45 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,424

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGRK2 papersNewest fiscal year
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors452025
R01EY011500Structure-function studies of visual arrestin192025
R01MH054137Structure and Function of Dopamine Receptors152025
R01DA012864Mechanisms and Cellular Function of Opioid Receptor Endocytosis102025
R01HL056687Mechanisms of Maladaptation in Heart Failure102025
P30CA016672Cancer Center Support Grant62025
R01CA124332Regulation of KSHV replication by N6-methyladenosine (m6A)62025
R01HL058506G Protein-Coupled Receptor Regulation in Airway Myocytes62025
R01MH112205Molecular Details of Psychoactive Drug Actions62025
R35GM118063Cell signaling in development and regeneration62025

1 to 10 of 2,424Source NIH's project files

See all 2,424 nih grants

Papers3,264

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2-Mediated µ-Opioid Receptor Internalization.Adv Sci (Weinh)202642817043PubTator, text miningPubMed
GRK2-JAK1 binding represses hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting STAT3 activation.Biochem Pharmacol202642815591PubTator, text miningPubMed
Molecular Mechanisms of Electroacupuncture-Induced Spinal Microglial Reprogramming in Neuropathic Pain: A Systematic Search-Narrative Review.Brain Sci202642793339PubTator, text miningPubMed
From Traditional Remedy to Evidence-Based Phytotherapeutic Agent: Hedera helix L. in Respiratory Medicine.Plants (Basel)202642739377PubTator, text miningPubMed
Retraction notice to "Paroxetine attenuates doxorubicin-induced cardiotoxicity: Integrated network pharmacology, molecular modeling, and in vivo evidence consistent with modulation of GRK2/iNOS-related pathways" [Toxicol. Appl. Pharmacol. 513 (2026) 117864].
Toxicol Appl Pharmacol202642735829PubTator, text miningPubMed
[The relationship between serum G protein-coupled receptor kinase 2 level and the occurrence of sepsis-associated liver injury].Zhonghua Wei Zhong Bing Ji Jiu Yi Xue202642693972PubTator, text miningPubMed
Beyond β-Adrenergic Receptor Brake: Compartment-Selective GRK2 Programs from Heart Failure to Cardio-Oncology.Kinases Phosphatases202642614945PubTator, text miningPubMed
Recent advances in the development of GRK2 inhibitors: blocking the interaction of GRK2 with its partners.Acta Pharmacol Sin202642410249PubTator, text miningPubMed
Beyond Raf-1 inhibition: RKIP's multifaceted roles in cellular homeostasis.Biochim Biophys Acta Rev Cancer202642323054PubTator, text miningPubMed
Fast pairwise coalescence enables gene-resolution scans for recent selection in diverse human populations.bioRxiv202642239206PubTator, text miningPubMed

1 to 10 of 3,264

See all 3,264 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/156

GET https://conductscience.org/api/genes/v1/156/patents?page=2