Gene · 156
GRK2: G protein-coupled receptor kinase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GRK2: G protein-coupled receptor kinase 2. Genes, record 156. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/156
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P25098 | G protein-coupled receptor kinase 2 | 689 | 20 | Ensembl, GeneID, HGNC |
Source UniProt
Patents45
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 36848 | P25098 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4817 | P25098 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4391 | P25098 | Espacenet |
| JP 2025154589 A | 2025-10-10 | 9 | P25098 | Espacenet |
| JP 2025154616 A | 2025-10-10 | 9 | P25098 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4391 | P25098 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4817 | P25098 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 3451 | P25098 | Espacenet |
| JP 2023123507 A | 2023-09-05 | 227 | P25098 | Espacenet |
| JP 2023527559 A | 2023-06-29 | 2 | P25098 | Espacenet |
1 to 10 of 45
See all 45 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,424
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GRK2 papers | Newest fiscal year |
|---|---|---|---|
| R01HL016037 | Molecular Regulation of Cardiovascular 7 TM Receptors | 45 | 2025 |
| R01EY011500 | Structure-function studies of visual arrestin | 19 | 2025 |
| R01MH054137 | Structure and Function of Dopamine Receptors | 15 | 2025 |
| R01DA012864 | Mechanisms and Cellular Function of Opioid Receptor Endocytosis | 10 | 2025 |
| R01HL056687 | Mechanisms of Maladaptation in Heart Failure | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| R01CA124332 | Regulation of KSHV replication by N6-methyladenosine (m6A) | 6 | 2025 |
| R01HL058506 | G Protein-Coupled Receptor Regulation in Airway Myocytes | 6 | 2025 |
| R01MH112205 | Molecular Details of Psychoactive Drug Actions | 6 | 2025 |
| R35GM118063 | Cell signaling in development and regeneration | 6 | 2025 |
1 to 10 of 2,424Source NIH's project files
See all 2,424 nih grantsPapers3,264
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2-Mediated µ-Opioid Receptor Internalization. | Adv Sci (Weinh) | 2026 | 42817043 | PubTator, text mining | PubMed |
| GRK2-JAK1 binding represses hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting STAT3 activation. | Biochem Pharmacol | 2026 | 42815591 | PubTator, text mining | PubMed |
| Molecular Mechanisms of Electroacupuncture-Induced Spinal Microglial Reprogramming in Neuropathic Pain: A Systematic Search-Narrative Review. | Brain Sci | 2026 | 42793339 | PubTator, text mining | PubMed |
| From Traditional Remedy to Evidence-Based Phytotherapeutic Agent: Hedera helix L. in Respiratory Medicine. | Plants (Basel) | 2026 | 42739377 | PubTator, text mining | PubMed |
Retraction notice to "Paroxetine attenuates doxorubicin-induced cardiotoxicity: Integrated network pharmacology, molecular modeling, and in vivo evidence consistent with modulation of GRK2/iNOS-related pathways" [Toxicol. Appl. Pharmacol. 513 (2026) 117864]. | Toxicol Appl Pharmacol | 2026 | 42735829 | PubTator, text mining | PubMed |
| [The relationship between serum G protein-coupled receptor kinase 2 level and the occurrence of sepsis-associated liver injury]. | Zhonghua Wei Zhong Bing Ji Jiu Yi Xue | 2026 | 42693972 | PubTator, text mining | PubMed |
| Beyond β-Adrenergic Receptor Brake: Compartment-Selective GRK2 Programs from Heart Failure to Cardio-Oncology. | Kinases Phosphatases | 2026 | 42614945 | PubTator, text mining | PubMed |
| Recent advances in the development of GRK2 inhibitors: blocking the interaction of GRK2 with its partners. | Acta Pharmacol Sin | 2026 | 42410249 | PubTator, text mining | PubMed |
| Beyond Raf-1 inhibition: RKIP's multifaceted roles in cellular homeostasis. | Biochim Biophys Acta Rev Cancer | 2026 | 42323054 | PubTator, text mining | PubMed |
| Fast pairwise coalescence enables gene-resolution scans for recent selection in diverse human populations. | bioRxiv | 2026 | 42239206 | PubTator, text mining | PubMed |
1 to 10 of 3,264
See all 3,264 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/156
GET https://conductscience.org/api/genes/v1/156/patents?page=2