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Gene · 1592

CYP26A1: cytochrome P450 family 26 subfamily A member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CYP26A1: cytochrome P450 family 26 subfamily A member 1. Genes, record 1592. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1592

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Gene

Symbol
CYP26A1
HGNC
Name
cytochrome P450 family 26 subfamily A member 1
HGNC
NCBI Gene ID
1592
NCBI Gene
HGNC ID
HGNC:2603
HGNC
Ensembl
ENSG00000095596
NCBI Gene
Aliases
CP26, CYP26, P450RAI, P450RAI1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43174Cytochrome P450 26A14970Ensembl, GeneID, HGNC

Source UniProt

Patents12

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442903O43174Espacenet
EP 4641201 A22025-10-29429O43174Espacenet
JP 2025517969 A2025-06-12429O43174Espacenet
US 11446398 B22022-09-2022032O43174Espacenet
JP 2022524081 A2022-04-27125003O43174Espacenet
US 11078247 B22021-08-032807O43174Espacenet
JP 2019054813 A2019-04-11223338O43174Espacenet
JP 2017121241 A2017-07-13223338O43174Espacenet
JP 2015516143 A2015-06-08223338O43174Espacenet
US 8586006 B22013-11-1956076O43174Espacenet

1 to 10 of 12

See all 12 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
TALAROZOLECHEMBL459505Cytochrome P450 26A1 inhibitorINHIBITOR

Source ChEMBL

Trials4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00725439TALAROZOLEPHASE2ClinicalTrials.gov
NCT00725348TALAROZOLEPHASE2ClinicalTrials.gov
NCT00719121TALAROZOLEPHASE1ClinicalTrials.gov
NCT00716144TALAROZOLEPHASE22018-01-29ClinicalTrials.gov

NIH grants1,085

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCYP26A1 papersNewest fiscal year
T32DK007247Diabetes, Obesity and Metabolism Training Program82025
ZIABC005562Xenobiotic receptors62025
P30CA016672Cancer Center Support Grant52025
R01EY009339Retinoids in Vision52025
R01HD010808Hormonal Regulation Sertoli Cell Maturation52025
P30CA006973Regional Oncology Research Center42025
P30CA016058Cancer Center Support Grant42025
P30DK017047Diabetes Research Center42025
ZIABC005708Xenobiotic metabolism, cancer chemoprevention and cancer biomarkers42025
P30EY011373CWRU NEI Vision Center Core Grant32025

1 to 10 of 1,085Source NIH's project files

See all 1,085 nih grants

Papers1,665

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
An NR2F1-dependent retinoic acid network controls retinal specialization in mice and reveals foveal hypoplasia in patients with BBSOAS.bioRxiv202642818154PubTator, text miningPubMed
Human Organoids Reveal PTEN-Driven Mesendoderm Specification via Retinoic Acid Signaling Suppression.Research (Wash D C)202642602118PubTator, text miningPubMed
ATF3/SOX11-regulated FST activates IGF1R-ERK/AKT-Sp1 signaling to sustain trigeminal neuropathic pain.Acta Pharmacol Sin202642477143PubTator, text miningPubMed
Elevated ESR2 and BRCA1 gene expression in adenomyosis associated with endometrial cancer: a pilot study.Gynecol Endocrinol202642329179PubTator, text miningPubMed
Screening of cytochrome CYP26A1 expression in different bone tumors.BMC Cancer202642316073PubTator, text miningPubMed
Genome-wide analysis implicates inner ear development in Ménière disease.Am J Hum Genet202642302782PubTator, text miningPubMed
Retinoic acid regulates foveal development in the human retina.Cell Rep202642213783PubTator, text miningPubMed
Bilateral bifoveate retina in a human resembling lizard foveal architecture.Ophthalmic Genet202642210632PubTator, text miningPubMed
A Sertoli valve niche at the terminal end of seminiferous tubules for mammalian spermatogenic stem cells.Curr Top Dev Biol202642097811PubTator, text miningPubMed
New insights into the role of CYP26 in retinoic acid clearance.Expert Opin Drug Metab Toxicol202642023600PubTator, text miningPubMed

1 to 10 of 1,665

See all 1,665 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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