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Gene · 163702

IFNLR1: interferon lambda receptor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IFNLR1: interferon lambda receptor 1. Genes, record 163702. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/163702

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Gene

Symbol
IFNLR1
HGNC
Name
interferon lambda receptor 1
HGNC
NCBI Gene ID
163702
NCBI Gene
HGNC ID
HGNC:18584
HGNC
Ensembl
ENSG00000185436
NCBI Gene
Aliases
CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8IU57Interferon lambda receptor 15208Ensembl, GeneID, HGNC

Source UniProt

Patents130

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450230Q8IU57Espacenet
EP 4650780 A22025-11-195743Q8IU57Espacenet
EP 4641201 A22025-10-295397Q8IU57Espacenet
EP 4633648 A12025-10-2250Q8IU57Espacenet
JP 2025147176 A2025-10-066760Q8IU57Espacenet
JP 2025529142 A2025-09-042046Q8IU57Espacenet
JP 2025529142 A2025-09-046666Q8IU57Espacenet
US 12371689 B22025-07-292046Q8IU57Espacenet
US 12371689 B22025-07-296666Q8IU57Espacenet
JP 2025517969 A2025-06-125397Q8IU57Espacenet

1 to 10 of 130

See all 130 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
PEGINTERFERON LAMBDA-1ACHEMBL2108723Interferon lambda receptor agonistAGONIST

Source ChEMBL

Trials22

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05953545PEGINTERFERON LAMBDA-1APHASE2ClinicalTrials.gov
NCT04967430PEGINTERFERON LAMBDA-1APHASE3ClinicalTrials.gov
NCT04534673PEGINTERFERON LAMBDA-1APHASE2ClinicalTrials.gov
NCT04388709PEGINTERFERON LAMBDA-1APHASE2ClinicalTrials.gov
NCT04354259PEGINTERFERON LAMBDA-1APHASE2ClinicalTrials.gov
NCT04344600PEGINTERFERON LAMBDA-1APHASE22022-07-14ClinicalTrials.gov
NCT04343976PEGINTERFERON LAMBDA-1APHASE22022-07-21ClinicalTrials.gov
NCT04331899PEGINTERFERON LAMBDA-1APHASE22021-04-22ClinicalTrials.gov
NCT02765802PEGINTERFERON LAMBDA-1APHASE22023-01-17ClinicalTrials.gov
NCT02063607PEGINTERFERON LAMBDA-1APHASE1ClinicalTrials.gov

1 to 10 of 22

See all 22 trials

NIH grants1,015

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIFNLR1 papersNewest fiscal year
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success92025
R01AI121066Innate control of the inflammatory process during fungal infections72025
R01DK115217Type III interferon Control of Mucosal Immunity72025
P20GM130457COBRE in Digestive and Liver Disease52025
P30CA008748Cancer Center Support Grant52025
P30DK034854Integrated Epithelial and Muscosal Biology52025
P30DK123704MUSC Digestive Disease Research Core Center52025
R01AI051321Structure-based engineering of immune cytokine signaling52025
T32AI007172Infectious Disease/Basic Microbial Pathogenic Mechanisms52025
R01AI163029Inborn errors of immunity in patients with life-threatening COVID-1942025

1 to 10 of 1,015Source NIH's project files

See all 1,015 nih grants

Papers1,320

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Interferon-λ receptor positive monocytes/macrophages orchestrate a pro-fibrotic immune environment in hepatitis B virus-related liver fibrosis.Clin Sci (Lond)202642742113PubTator, text miningPubMed
Triple IFN pathway deficiency sensitizes mice to human respiratory virus infection independent of human viral receptor expression.Nat Commun202642463654PubTator, text miningPubMed
Subtype-specific functions of basal IFNλs.J Virol202642227763PubTator, text miningPubMed
Mechanisms of Differential Signal Transduction by Interferon Lambda Receptor 1 Variants.J Innate Immun202642213608PubTator, text miningPubMed
Mapping the Causal Landscape of Psoriasis: A Systematic Mendelian Randomization Evidence Synthesis and Development of the MR-PsO Atlas Platform.Exp Dermatol202642157626PubTator, text miningPubMed
Interferon lambda in anti-viral defense and cancer: dual roles, mechanism and therapeutic potential.J Transl Med202642092929PubTator, text miningPubMed
Dual regulation of antiviral IFN response by Scutellariae Radix: Therapeutic implications for influenza.J Pharm Anal202641960576PubTator, text miningPubMed
Interferon dynamics in deltaretroviruses: why HTLV-1 evades, but BLV responds.Mol Biol Rep202641920397PubTator, text miningPubMed
Multi‑omics and their integration in psoriasis research (Review).Mol Med Rep202641891974PubTator, text miningPubMed
MERS-CoV and SARS-CoV-1 proteins inhibit the IFN-α JAK/STAT pathway of epithelial cells, via IFN-λ-induced USP18.Front Immunol202641798916PubTator, text miningPubMed

1 to 10 of 1,320

See all 1,320 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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