Gene · 163702
IFNLR1: interferon lambda receptor 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IFNLR1: interferon lambda receptor 1. Genes, record 163702. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/163702
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8IU57 | Interferon lambda receptor 1 | 520 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents130
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 50230 | Q8IU57 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5743 | Q8IU57 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5397 | Q8IU57 | Espacenet |
| EP 4633648 A1 | 2025-10-22 | 50 | Q8IU57 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6760 | Q8IU57 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2046 | Q8IU57 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6666 | Q8IU57 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2046 | Q8IU57 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6666 | Q8IU57 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5397 | Q8IU57 | Espacenet |
1 to 10 of 130
See all 130 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| PEGINTERFERON LAMBDA-1A | CHEMBL2108723 | Interferon lambda receptor agonist | AGONIST |
Source ChEMBL
Trials22
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05953545 | PEGINTERFERON LAMBDA-1A | PHASE2 | ClinicalTrials.gov | |
| NCT04967430 | PEGINTERFERON LAMBDA-1A | PHASE3 | ClinicalTrials.gov | |
| NCT04534673 | PEGINTERFERON LAMBDA-1A | PHASE2 | ClinicalTrials.gov | |
| NCT04388709 | PEGINTERFERON LAMBDA-1A | PHASE2 | ClinicalTrials.gov | |
| NCT04354259 | PEGINTERFERON LAMBDA-1A | PHASE2 | ClinicalTrials.gov | |
| NCT04344600 | PEGINTERFERON LAMBDA-1A | PHASE2 | 2022-07-14 | ClinicalTrials.gov |
| NCT04343976 | PEGINTERFERON LAMBDA-1A | PHASE2 | 2022-07-21 | ClinicalTrials.gov |
| NCT04331899 | PEGINTERFERON LAMBDA-1A | PHASE2 | 2021-04-22 | ClinicalTrials.gov |
| NCT02765802 | PEGINTERFERON LAMBDA-1A | PHASE2 | 2023-01-17 | ClinicalTrials.gov |
| NCT02063607 | PEGINTERFERON LAMBDA-1A | PHASE1 | ClinicalTrials.gov |
1 to 10 of 22
See all 22 trialsNIH grants1,015
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IFNLR1 papers | Newest fiscal year |
|---|---|---|---|
| UL1TR001866 | Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success | 9 | 2025 |
| R01AI121066 | Innate control of the inflammatory process during fungal infections | 7 | 2025 |
| R01DK115217 | Type III interferon Control of Mucosal Immunity | 7 | 2025 |
| P20GM130457 | COBRE in Digestive and Liver Disease | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 5 | 2025 |
| P30DK123704 | MUSC Digestive Disease Research Core Center | 5 | 2025 |
| R01AI051321 | Structure-based engineering of immune cytokine signaling | 5 | 2025 |
| T32AI007172 | Infectious Disease/Basic Microbial Pathogenic Mechanisms | 5 | 2025 |
| R01AI163029 | Inborn errors of immunity in patients with life-threatening COVID-19 | 4 | 2025 |
1 to 10 of 1,015Source NIH's project files
See all 1,015 nih grantsPapers1,320
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Interferon-λ receptor positive monocytes/macrophages orchestrate a pro-fibrotic immune environment in hepatitis B virus-related liver fibrosis. | Clin Sci (Lond) | 2026 | 42742113 | PubTator, text mining | PubMed |
| Triple IFN pathway deficiency sensitizes mice to human respiratory virus infection independent of human viral receptor expression. | Nat Commun | 2026 | 42463654 | PubTator, text mining | PubMed |
| Subtype-specific functions of basal IFNλs. | J Virol | 2026 | 42227763 | PubTator, text mining | PubMed |
| Mechanisms of Differential Signal Transduction by Interferon Lambda Receptor 1 Variants. | J Innate Immun | 2026 | 42213608 | PubTator, text mining | PubMed |
| Mapping the Causal Landscape of Psoriasis: A Systematic Mendelian Randomization Evidence Synthesis and Development of the MR-PsO Atlas Platform. | Exp Dermatol | 2026 | 42157626 | PubTator, text mining | PubMed |
| Interferon lambda in anti-viral defense and cancer: dual roles, mechanism and therapeutic potential. | J Transl Med | 2026 | 42092929 | PubTator, text mining | PubMed |
| Dual regulation of antiviral IFN response by Scutellariae Radix: Therapeutic implications for influenza. | J Pharm Anal | 2026 | 41960576 | PubTator, text mining | PubMed |
| Interferon dynamics in deltaretroviruses: why HTLV-1 evades, but BLV responds. | Mol Biol Rep | 2026 | 41920397 | PubTator, text mining | PubMed |
| Multi‑omics and their integration in psoriasis research (Review). | Mol Med Rep | 2026 | 41891974 | PubTator, text mining | PubMed |
| MERS-CoV and SARS-CoV-1 proteins inhibit the IFN-α JAK/STAT pathway of epithelial cells, via IFN-λ-induced USP18. | Front Immunol | 2026 | 41798916 | PubTator, text mining | PubMed |
1 to 10 of 1,320
See all 1,320 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/163702
GET https://conductscience.org/api/genes/v1/163702/patents?page=2