Gene · 164656
TMPRSS6: transmembrane serine protease 6
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TMPRSS6: transmembrane serine protease 6. Genes, record 164656. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/164656
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8IU80 | Transmembrane protease serine 6 | 811 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents54
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 67787 | Q8IU80 | Espacenet |
| JP 2025172069 A | 2025-11-20 | 605 | Q8IU80 | Espacenet |
| JP 2025166832 A | 2025-11-06 | 2 | Q8IU80 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 887 | Q8IU80 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5882 | Q8IU80 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4982 | Q8IU80 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4982 | Q8IU80 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 887 | Q8IU80 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5882 | Q8IU80 | Espacenet |
| US 12247982 B2 | 2025-03-11 | 605 | Q8IU80 | Espacenet |
1 to 10 of 54
See all 54 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| SAPABLURSEN | CHEMBL4650478 | Transmembrane protease serine 6 mRNA antisense inhibitor | ANTISENSE INHIBITOR |
Source ChEMBL
Trials3
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07429266 | SAPABLURSEN | PHASE3 | ClinicalTrials.gov | |
| NCT05143957 | SAPABLURSEN | PHASE2 | ClinicalTrials.gov | |
| NCT04059406 | SAPABLURSEN | PHASE2 | 2025-02-18 | ClinicalTrials.gov |
NIH grants738
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TMPRSS6 papers | Newest fiscal year |
|---|---|---|---|
| R01DK095112 | Regulatory Role of Transferrin in Erythropoiesis and Iron Metabolism | 13 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 7 | 2025 |
| R01DK102791 | Roles of Neogenin and Matriptase-2 in Iron Homeostasis | 6 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 6 | 2025 |
| P30CA062203 | Cancer Center Support Grant | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| UL1TR001881 | UCLA Clinical and Translational Science Institute | 4 | 2025 |
| ZIAAG001050 | The InChianti Study | 4 | 2025 |
| P30CA134274 | UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT | 3 | 2025 |
| T32CA009531 | Training Program in the Biology of Cancer | 3 | 2025 |
1 to 10 of 738Source NIH's project files
See all 738 nih grantsPapers978
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Ferritin Normalization Is Not Disease Control in HFE-Related Hemochromatosis: Residual Risk, Transferrin Saturation, and the Hepcidin-Ferroportin Axis. | Eur J Haematol | 2026 | 42764193 | PubTator, text mining | PubMed |
| Deciphering novel targets in salivary gland pleomorphic adenoma by integrating plasma proteomics and parotid transcriptomics analyses. | J Dent Sci | 2026 | 42688628 | PubTator, text mining | PubMed |
| Sapablursen for Erythrocytosis Control in Patients with Polycythemia Vera. | Blood | 2026 | 42611791 | PubTator, text mining | PubMed |
| Are sustainable plant-based diets suitable for all? A nutrigenetic perspective. | Nutr Health | 2026 | 42593171 | PubTator, text mining | PubMed |
| Association of TMPRSS6 gene polymorphisms with severity of iron deficiency anemia in Uzbek schoolchildren: a molecular case-control study. | Arch Med Sci | 2026 | 42540599 | PubTator, text mining | PubMed |
| Hepcidin as a Molecular Hub of Iron Homeostasis: From BMP-SMAD Signaling to Therapeutic Modulation. | Biomolecules | 2026 | 42509741 | PubTator, text mining | PubMed |
| Between scarcity and surfeit: a familial tale of contradictory iron disorders (β -thalassemia and iron-refractory iron deficiency anemia). | Ann Hematol | 2026 | 42479051 | PubTator, text mining | PubMed |
| Correction to 'Targeting the Liver Serine Protease TMPRSS6 Ameliorates Steatosis and Attenuates Fibrosis in Experimental MASLD'. | Liver Int | 2026 | 42454756 | PubTator, text mining | PubMed |
| Aberrant TMPRSS6-Protease Regulation of Disease Mutant HCN4-KCNE1 Channel Complex Depends on the KCNE1-G38S Polymorphism. | Arch Pharm (Weinheim) | 2026 | 42424558 | PubTator, text mining | PubMed |
| Deep Dive into Evolution: How Cetaceans Adapt Their Anticoagulant Genes for Underwater Survival. | J Mol Evol | 2026 | 42406052 | PubTator, text mining | PubMed |
1 to 10 of 978
See all 978 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/164656
GET https://conductscience.org/api/genes/v1/164656/patents?page=2