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Gene · 164656

TMPRSS6: transmembrane serine protease 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TMPRSS6: transmembrane serine protease 6. Genes, record 164656. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/164656

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Gene

Symbol
TMPRSS6
HGNC
Name
transmembrane serine protease 6
HGNC
NCBI Gene ID
164656
NCBI Gene
HGNC ID
HGNC:16517
HGNC
Ensembl
ENSG00000187045
NCBI Gene
Aliases
FLJ30744, IRIDA, MT2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8IU80Transmembrane protease serine 68111Ensembl, GeneID, HGNC

Source UniProt

Patents54

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467787Q8IU80Espacenet
JP 2025172069 A2025-11-20605Q8IU80Espacenet
JP 2025166832 A2025-11-062Q8IU80Espacenet
EP 4640849 A22025-10-29887Q8IU80Espacenet
EP 4641201 A22025-10-295882Q8IU80Espacenet
JP 2025529142 A2025-09-044982Q8IU80Espacenet
US 12371689 B22025-07-294982Q8IU80Espacenet
JP 2025519096 A2025-06-24887Q8IU80Espacenet
JP 2025517969 A2025-06-125882Q8IU80Espacenet
US 12247982 B22025-03-11605Q8IU80Espacenet

1 to 10 of 54

See all 54 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
SAPABLURSENCHEMBL4650478Transmembrane protease serine 6 mRNA antisense inhibitorANTISENSE INHIBITOR

Source ChEMBL

Trials3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07429266SAPABLURSENPHASE3ClinicalTrials.gov
NCT05143957SAPABLURSENPHASE2ClinicalTrials.gov
NCT04059406SAPABLURSENPHASE22025-02-18ClinicalTrials.gov

NIH grants738

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTMPRSS6 papersNewest fiscal year
R01DK095112Regulatory Role of Transferrin in Erythropoiesis and Iron Metabolism132025
P30DK063491Diabetes Research Center (DRC)72025
R01DK102791Roles of Neogenin and Matriptase-2 in Iron Homeostasis62025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal62025
P30CA062203Cancer Center Support Grant52025
P30CA016672Cancer Center Support Grant42025
UL1TR001881UCLA Clinical and Translational Science Institute42025
ZIAAG001050The InChianti Study42025
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT32025
T32CA009531Training Program in the Biology of Cancer32025

1 to 10 of 738Source NIH's project files

See all 738 nih grants

Papers978

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Ferritin Normalization Is Not Disease Control in HFE-Related Hemochromatosis: Residual Risk, Transferrin Saturation, and the Hepcidin-Ferroportin Axis.Eur J Haematol202642764193PubTator, text miningPubMed
Deciphering novel targets in salivary gland pleomorphic adenoma by integrating plasma proteomics and parotid transcriptomics analyses.J Dent Sci202642688628PubTator, text miningPubMed
Sapablursen for Erythrocytosis Control in Patients with Polycythemia Vera.Blood202642611791PubTator, text miningPubMed
Are sustainable plant-based diets suitable for all? A nutrigenetic perspective.Nutr Health202642593171PubTator, text miningPubMed
Association of TMPRSS6 gene polymorphisms with severity of iron deficiency anemia in Uzbek schoolchildren: a molecular case-control study.Arch Med Sci202642540599PubTator, text miningPubMed
Hepcidin as a Molecular Hub of Iron Homeostasis: From BMP-SMAD Signaling to Therapeutic Modulation.Biomolecules202642509741PubTator, text miningPubMed
Between scarcity and surfeit: a familial tale of contradictory iron disorders (β -thalassemia and iron-refractory iron deficiency anemia).Ann Hematol202642479051PubTator, text miningPubMed
Correction to 'Targeting the Liver Serine Protease TMPRSS6 Ameliorates Steatosis and Attenuates Fibrosis in Experimental MASLD'.Liver Int202642454756PubTator, text miningPubMed
Aberrant TMPRSS6-Protease Regulation of Disease Mutant HCN4-KCNE1 Channel Complex Depends on the KCNE1-G38S Polymorphism.Arch Pharm (Weinheim)202642424558PubTator, text miningPubMed
Deep Dive into Evolution: How Cetaceans Adapt Their Anticoagulant Genes for Underwater Survival.J Mol Evol202642406052PubTator, text miningPubMed

1 to 10 of 978

See all 978 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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