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Gene · 1733

DIO1: iodothyronine deiodinase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DIO1: iodothyronine deiodinase 1. Genes, record 1733. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1733

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Gene

Symbol
DIO1
HGNC
Name
iodothyronine deiodinase 1
HGNC
NCBI Gene ID
1733
NCBI Gene
HGNC ID
HGNC:2883
HGNC
Ensembl
ENSG00000211452
NCBI Gene
Aliases
5DI, THMA2, TXDI1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49895Type I iodothyronine deiodinase2490Ensembl, GeneID, HGNC

Source UniProt

Patents3

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443517P49895Espacenet
JP 2025529142 A2025-09-041262P49895Espacenet
US 12371689 B22025-07-291262P49895Espacenet

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
PROPYLTHIOURACILCHEMBL1518Type I iodothyronine deiodinase (Type-I 5'-deiodinase) (DIOI) (Type 1 DI) (5DI) inhibitorINHIBITOR

Source ChEMBL

Trials9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05762146PROPYLTHIOURACILPHASE2ClinicalTrials.gov
NCT05118542PROPYLTHIOURACILPHASE3ClinicalTrials.gov
NCT04936698PROPYLTHIOURACILClinicalTrials.gov
NCT04776499PROPYLTHIOURACILPHASE1ClinicalTrials.gov
NCT03447093PROPYLTHIOURACILClinicalTrials.gov
NCT03433352PROPYLTHIOURACILClinicalTrials.gov
NCT03299452PROPYLTHIOURACILPHASE2ClinicalTrials.gov
NCT01436994PROPYLTHIOURACILPHASE3ClinicalTrials.gov
NCT00846755PROPYLTHIOURACILClinicalTrials.gov

NIH grants382

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDIO1 papersNewest fiscal year
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
R01DK015070Thyroid Physiology Studies of Inherited Disorders32025
R01DK077148Metabolic and xenobiotic control of thyroid hormone metabolism32025
ZIAAG000965The Aging Genome Association Study "AGE-GAIN"32025
P30CA008748Cancer Center Support Grant22025
P30CA046934University of Colorado Cancer Center Support Grant22025
P30ES019776HERCULES: Exposome Research Center22025
R01DK107451The role of AEG-1 in NASH and NASH-HCC22025
R01DK128390Selenium metabolism in cold-induced adaptive thermogenesis22025
I01BX001966Thyroid Hormone and Neuronal Protection12025

1 to 10 of 382Source NIH's project files

See all 382 nih grants

Papers950

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Regulating xenophagy and phenotype of macrophages by selenium-doped nanoleaves on Zn-based implants for infected bone integration.Bioact Mater202642064145PubTator, text miningPubMed
Colorimetric Assessment of Deiodinase 1 Activity in Human Liver Microsomes Using the Sandell-Kolthoff Reaction.J Vis Exp202642044071PubTator, text miningPubMed
Novel nutraceutical combination restores hepatic deiodinase expression and protein levels under inflammatory conditions: evidence from an in vitro model.Front Nutr202641971366PubTator, text miningPubMed
Signal Amplification in the HPT Axis-Evidence for Its Existence, Location, Significance, and Molecular Mechanisms.Acta Physiol (Oxf)202641862191PubTator, text miningPubMed
Plant-derived nutritional components in thyroid disease-related neuropsychiatric disorders: mechanistic insights and advances.Front Nutr202641798846PubTator, text miningPubMed
Cardiovascular Risk Determinants in Euthyroid Patients with Obesity: The Strange Case of TSH in Primary Prevention.J Clin Med202641753115PubTator, text miningPubMed
Acetate Metabolism in Thyroid Cancer Progression.Int J Mol Sci202641752148PubTator, text miningPubMed
Emerging Roles, Mechanisms, and Therapeutic Potential of Thyroid Hormones in Neurodegenerative Diseases: A Review.Brain Sci202641750229PubTator, text miningPubMed
Single-cell analysis reveals the cellular and transcriptional heterogeneity of the normal pediatric thyroid.Front Endocrinol (Lausanne)202641727685PubTator, text miningPubMed
Genetics of selenoproteins and selenoprotein metabolism - An overview of current concepts and emerging aspects.Redox Biol202641719757PubTator, text miningPubMed

1 to 10 of 950

See all 950 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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