Gene · 1733
DIO1: iodothyronine deiodinase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DIO1: iodothyronine deiodinase 1. Genes, record 1733. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1733
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49895 | Type I iodothyronine deiodinase | 249 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents3
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
Drugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| PROPYLTHIOURACIL | CHEMBL1518 | Type I iodothyronine deiodinase (Type-I 5'-deiodinase) (DIOI) (Type 1 DI) (5DI) inhibitor | INHIBITOR |
Source ChEMBL
Trials9
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05762146 | PROPYLTHIOURACIL | PHASE2 | ClinicalTrials.gov | |
| NCT05118542 | PROPYLTHIOURACIL | PHASE3 | ClinicalTrials.gov | |
| NCT04936698 | PROPYLTHIOURACIL | ClinicalTrials.gov | ||
| NCT04776499 | PROPYLTHIOURACIL | PHASE1 | ClinicalTrials.gov | |
| NCT03447093 | PROPYLTHIOURACIL | ClinicalTrials.gov | ||
| NCT03433352 | PROPYLTHIOURACIL | ClinicalTrials.gov | ||
| NCT03299452 | PROPYLTHIOURACIL | PHASE2 | ClinicalTrials.gov | |
| NCT01436994 | PROPYLTHIOURACIL | PHASE3 | ClinicalTrials.gov | |
| NCT00846755 | PROPYLTHIOURACIL | ClinicalTrials.gov |
NIH grants382
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DIO1 papers | Newest fiscal year |
|---|---|---|---|
| ZIACP010121 | Molecular Epidemiology Studies of Occupational and Environmental Exposures | 4 | 2025 |
| R01DK015070 | Thyroid Physiology Studies of Inherited Disorders | 3 | 2025 |
| R01DK077148 | Metabolic and xenobiotic control of thyroid hormone metabolism | 3 | 2025 |
| ZIAAG000965 | The Aging Genome Association Study "AGE-GAIN" | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 2 | 2025 |
| P30ES019776 | HERCULES: Exposome Research Center | 2 | 2025 |
| R01DK107451 | The role of AEG-1 in NASH and NASH-HCC | 2 | 2025 |
| R01DK128390 | Selenium metabolism in cold-induced adaptive thermogenesis | 2 | 2025 |
| I01BX001966 | Thyroid Hormone and Neuronal Protection | 1 | 2025 |
1 to 10 of 382Source NIH's project files
See all 382 nih grantsPapers950
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Regulating xenophagy and phenotype of macrophages by selenium-doped nanoleaves on Zn-based implants for infected bone integration. | Bioact Mater | 2026 | 42064145 | PubTator, text mining | PubMed |
| Colorimetric Assessment of Deiodinase 1 Activity in Human Liver Microsomes Using the Sandell-Kolthoff Reaction. | J Vis Exp | 2026 | 42044071 | PubTator, text mining | PubMed |
| Novel nutraceutical combination restores hepatic deiodinase expression and protein levels under inflammatory conditions: evidence from an in vitro model. | Front Nutr | 2026 | 41971366 | PubTator, text mining | PubMed |
| Signal Amplification in the HPT Axis-Evidence for Its Existence, Location, Significance, and Molecular Mechanisms. | Acta Physiol (Oxf) | 2026 | 41862191 | PubTator, text mining | PubMed |
| Plant-derived nutritional components in thyroid disease-related neuropsychiatric disorders: mechanistic insights and advances. | Front Nutr | 2026 | 41798846 | PubTator, text mining | PubMed |
| Cardiovascular Risk Determinants in Euthyroid Patients with Obesity: The Strange Case of TSH in Primary Prevention. | J Clin Med | 2026 | 41753115 | PubTator, text mining | PubMed |
| Acetate Metabolism in Thyroid Cancer Progression. | Int J Mol Sci | 2026 | 41752148 | PubTator, text mining | PubMed |
| Emerging Roles, Mechanisms, and Therapeutic Potential of Thyroid Hormones in Neurodegenerative Diseases: A Review. | Brain Sci | 2026 | 41750229 | PubTator, text mining | PubMed |
| Single-cell analysis reveals the cellular and transcriptional heterogeneity of the normal pediatric thyroid. | Front Endocrinol (Lausanne) | 2026 | 41727685 | PubTator, text mining | PubMed |
| Genetics of selenoproteins and selenoprotein metabolism - An overview of current concepts and emerging aspects. | Redox Biol | 2026 | 41719757 | PubTator, text mining | PubMed |
1 to 10 of 950
See all 950 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1733
GET https://conductscience.org/api/genes/v1/1733/grants?page=2