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Gene · 18

ABAT: 4-aminobutyrate aminotransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ABAT: 4-aminobutyrate aminotransferase. Genes, record 18. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/18

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Gene

Symbol
ABAT
HGNC
Name
4-aminobutyrate aminotransferase
HGNC
NCBI Gene ID
18
NCBI Gene
HGNC ID
HGNC:23
HGNC
Ensembl
ENSG00000183044
NCBI Gene
Aliases
GABA-AT, GABA-T, GABAT, NPD009
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P804044-aminobutyrate aminotransferase, mitochondrial5000Ensembl, GeneID, HGNC

Source UniProt

Patents53

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435728P80404Espacenet
JP 2026004568 A2026-01-1435729P80404Espacenet
JP 2026004568 A2026-01-1435730P80404Espacenet
JP 2025062604 A2025-04-14314P80404Espacenet
JP 2025062604 A2025-04-14315P80404Espacenet
JP 2025062604 A2025-04-14316P80404Espacenet
JP 2025032204 A2025-03-1123830P80404Espacenet
JP 2025032204 A2025-03-1123837P80404Espacenet
JP 2025032204 A2025-03-1123840P80404Espacenet
EP 4461818 A22024-11-1323830P80404Espacenet

1 to 10 of 53

See all 53 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
VIGABATRINCHEMBL89598Gamma-amino-N-butyrate transaminase inhibitorINHIBITOR

Source ChEMBL

Trials20

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05128344VIGABATRINPHASE3ClinicalTrials.gov
NCT04772547VIGABATRINPHASE22024-07-12ClinicalTrials.gov
NCT04321395VIGABATRINPHASE22025-01-14ClinicalTrials.gov
NCT04302116VIGABATRINClinicalTrials.gov
NCT04062890VIGABATRINPHASE2ClinicalTrials.gov
NCT03421496VIGABATRINPHASE32023-06-07ClinicalTrials.gov
NCT03347526VIGABATRINPHASE3ClinicalTrials.gov
NCT03003143VIGABATRINClinicalTrials.gov
NCT02299115VIGABATRINPHASE3ClinicalTrials.gov
NCT02220114VIGABATRINClinicalTrials.gov

1 to 10 of 20

See all 20 trials

NIH grants1,085

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleABAT papersNewest fiscal year
P30DA018310Neurometabolomics and Neuroproteomics Center on Cell-Cell Signaling82025
R01HD091142Natural History of Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD), a Heritable Disorder of GABA Metabolism72025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
R01NS083726Personalized Functional Genomics for Mitochondrial Encephalopathy Gene Discovery52025
UL1TR001863Yale Clinical and Translational Science Award52025
ZIAMH002803Magnetic Resonance Spectroscopy and Imaging Studies of Brain Functions52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
R01CA260250Ornithine Aminotransferase Inactivation, a New Approach for Treatment of Cancers32025
P30CA010815Consolidated Basic Cancer Research Program22025
P30CA014236Cancer Center Support Grant (CCSG)22025

1 to 10 of 1,085Source NIH's project files

See all 1,085 nih grants

Papers2,776

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Synthesis, Spectroscopic Characterization, Molecular Docking Studies Toward the GABAA Receptor, ADMET Prediction, GABA Aminotransferase Inhibition, and Anxiolytic Evaluation of Novel Thiazine Derivatives.
Pharmaceuticals (Basel)202642797410PubTator, text miningPubMed
Pharmacokinetics of Loading Dose Vigabatrin Administered via Enteral Tube in Participants With Post-Anoxic Status Epilepticus.Pharmacotherapy202642723519PubTator, text miningPubMed
Satellite Glial Cells Synthesize and Release GABA to Activate Extrasynaptic GABAA Receptors That Modulate Dorsal Root Ganglia Neuron Excitability.Glia202642477993PubTator, text miningPubMed
Exploring the molecular association between Di(2-ethylhexyl)phthalate and dilated cardiomyopathy based on interpretable machine learning and molecular docking.Toxicol Res202642403687PubTator, text miningPubMed
Inactivation of ornithine aminotransferase by (1R,4S)-4-Amino-3-(trifluoromethyl)cyclopent-2-ene-1-carboxylic acid via a stable quinonoid intermediate.Med Chem Res202642078119PubTator, text miningPubMed
Blood-Based Epigenetic Signatures in Brazilian Males With Alcohol Use Disorder.Addict Biol202642047220PubTator, text miningPubMed
Heterogeneity of monogenic epilepsy in loci, phenotypes, and treatment approaches.Neurol Sci202641912906PubTator, text miningPubMed
Considerations for Carnosine Actions in Biology.Neurochem Res202641894036PubTator, text miningPubMed
Maternal paraben exposure during early pregnancy is associated with altered cord blood DNA methylation: The PREDO cohort.Environ Int202641886927PubTator, text miningPubMed
Glutamate decarboxylase 1 (GAD1) suppresses the progression of glioblastoma through GSK3β/β-catenin pathway.Cell Death Discov202641844572PubTator, text miningPubMed

1 to 10 of 2,776

See all 2,776 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/18

GET https://conductscience.org/api/genes/v1/18/patents?page=2