Gene · 1812
DRD1: dopamine receptor D1
11 sourcesgene-search-2026-11-11-0.1.0
Cite this record
ConductScience Library. DRD1: dopamine receptor D1. Genes, record 1812. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/1812
On this page
Gene
Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P21728 | Dopamine receptor D1 | 446 | 31 | Ensembl, GeneID, HGNC |
Source UniProt
Patents64
Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026062654 A | 2026-04-10 | 35 | P21728 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 44191 | P21728 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 44192 | P21728 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1318 | P21728 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1318 | P21728 | Espacenet |
| JP 2025081661 A | 2025-05-27 | 19 | P21728 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 27508 | P21728 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 27508 | P21728 | Espacenet |
| US 11860166 B2 | 2024-01-02 | 1 | P21728 | Espacenet |
| JP 2023156353 A | 2023-10-24 | 35 | P21728 | Espacenet |
1 to 10 of 64
See all 64 patentsDrugs16
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMINEPTINE | CHEMBL418995 | Dopamine D1 and D2 receptor antagonist | ANTAGONIST | ChEMBL |
| AMOXAPINE | CHEMBL1113 | Dopamine receptor antagonist | ANTAGONIST | ChEMBL |
| ECOPIPAM | CHEMBL298406 | Dopamine D1 receptor antagonist | ANTAGONIST | ChEMBL |
| ERGOLOID | CHEMBL2364968 | Dopamine receptor agonist | AGONIST | ChEMBL |
| ERGOLOID MESYLATES | CHEMBL2311030 | Dopamine receptor agonist | AGONIST | ChEMBL |
| FENOLDOPAM | CHEMBL588 | Dopamine D1 receptor agonist | AGONIST | ChEMBL |
| FENOLDOPAM MESYLATE | CHEMBL1026 | Dopamine D1 receptor agonist | AGONIST | ChEMBL |
| METHYLERGONOVINE | CHEMBL1201356 | Dopamine D1 receptor antagonist | ANTAGONIST | ChEMBL |
| METHYLERGONOVINE MALEATE | CHEMBL1200843 | Dopamine D1 receptor antagonist | ANTAGONIST | ChEMBL |
| MEVIDALEN | CHEMBL3421729 | Dopamine D1 receptor positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR | ChEMBL |
1 to 10 of 16
See all 16 drugsTrials47
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06538116 | MEVIDALEN | PHASE2 | ClinicalTrials.gov | |
| NCT05610189 | TAVAPADON | PHASE1 | ClinicalTrials.gov | |
| NCT05507372 | PIMOZIDE | ClinicalTrials.gov | ||
| NCT05030129 | ERGOLOID MESYLATES | PHASE2 | 2024-09-19 | ClinicalTrials.gov |
| NCT04760769 | TAVAPADON | PHASE3 | ClinicalTrials.gov | |
| NCT04542499 | TAVAPADON | PHASE3 | 2025-03-25 | ClinicalTrials.gov |
| NCT04529226 | PIMOZIDE | PHASE2 | ClinicalTrials.gov | |
| NCT04295642 | TAVAPADON | PHASE1 | ClinicalTrials.gov | |
| NCT04223193 | TAVAPADON | PHASE3 | 2025-11-21 | ClinicalTrials.gov |
| NCT04201093 | TAVAPADON | PHASE3 | 2025-07-28 | ClinicalTrials.gov |
1 to 10 of 47
See all 47 trialsNIH grants3,209
NIH projects whose papers are about the gene, through NIH's grant-paper links.
| Project | Title | Its papers about the gene | Newest fiscal year |
|---|---|---|---|
| ZIADA000493 | Functional and Pharmacological Significance of Receptor Heteromers in the CNS | 21 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 10 | 2025 |
| ZIAAA000550 | Neurobiology of Drug Reward and Addiction | 10 | 2025 |
| P50AA012870 | Center for the Translational Neuroscience of Alcoholism | 8 | 2025 |
| R01DA012864 | Mechanisms and Cellular Function of Opioid Receptor Endocytosis | 8 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 8 | 2025 |
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 7 | 2025 |
| ZIANS002263 | Molecular And Pharmacological Studies Of Dopamine Receptors | 6 | 2025 |
| P51OD011132 | Emory National Primate Research Center | 5 | 2025 |
| R01HL092961 | Epithelial-Mesenchymal Interactions in Fibrosis Resolution | 5 | 2025 |
1 to 10 of 3,209Source NIH's project files
See all 3,209 nih grantsPapers4,249
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| PMID | Found by | Source |
|---|---|---|
| 42818391 | PubTator, text mining | PubMed |
| 42817951 | PubTator, text mining | PubMed |
| 42747659 | PubTator, text mining | PubMed |
| 42740717 | PubTator, text mining | PubMed |
| 42711392 | PubTator, text mining | PubMed |
| 42650151 | PubTator, text mining | PubMed |
| 42624217 | PubTator, text mining | PubMed |
| 42599341 | PubTator, text mining | PubMed |
| 42576224 | PubTator, text mining | PubMed |
| 42567445 | PubTator, text mining | PubMed |
1 to 10 of 4,249
See all 4,249 papersSources 11
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNone stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GeneNone named. Public domain as US government information
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1812
GET https://conductscience.org/api/genes/v1/1812/patents?page=2