ConductScience.org, home

Gene · 1816

DRD5: dopamine receptor D5

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. DRD5: dopamine receptor D5. Genes, record 1816. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1816

On this page

Gene

Symbol
DRD5
HGNC
Name
dopamine receptor D5
HGNC
NCBI Gene ID
1816
NCBI Gene
HGNC ID
HGNC:3026
HGNC
Ensembl
ENSG00000169676
NCBI Gene
Aliases
DBDR, DRD1B, DRD1L2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P21918Dopamine receptor D54771Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444207P21918Espacenet
EP 4641201 A22025-10-293945P21918Espacenet
JP 2025529142 A2025-09-041322P21918Espacenet
US 12371689 B22025-07-291322P21918Espacenet
JP 2025517969 A2025-06-123945P21918Espacenet
US 11446398 B22022-09-2025466P21918Espacenet
US 11400116 B22022-08-02257P21918Espacenet
JP 2022524081 A2022-04-27128437P21918Espacenet
US 11078247 B22021-08-033264P21918Espacenet
KR 1020200143026 A2020-12-2313P21918Espacenet

1 to 10 of 40

See all 40 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMOXAPINECHEMBL1113Dopamine receptor antagonistANTAGONISTChEMBL
ERGOLOIDCHEMBL2364968Dopamine receptor agonistAGONISTChEMBL
ERGOLOID MESYLATESCHEMBL2311030Dopamine receptor agonistAGONISTChEMBL
PERGOLIDECHEMBL531Dopamine receptor agonistAGONISTChEMBL
PERGOLIDE MESYLATECHEMBL1275Dopamine receptor agonistAGONISTChEMBL
PIMOZIDECHEMBL1423Dopamine receptor antagonistANTAGONISTChEMBL
TAVAPADONCHEMBL3697617Dopamine D5 receptor partial agonistPARTIAL AGONISTChEMBL

Trials28

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05610189TAVAPADONPHASE1ClinicalTrials.gov
NCT05507372PIMOZIDEClinicalTrials.gov
NCT05030129ERGOLOID MESYLATESPHASE22024-09-19ClinicalTrials.gov
NCT04760769TAVAPADONPHASE3ClinicalTrials.gov
NCT04542499TAVAPADONPHASE32025-03-25ClinicalTrials.gov
NCT04529226PIMOZIDEPHASE2ClinicalTrials.gov
NCT04295642TAVAPADONPHASE1ClinicalTrials.gov
NCT04223193TAVAPADONPHASE32025-11-21ClinicalTrials.gov
NCT04201093TAVAPADONPHASE32025-07-28ClinicalTrials.gov
NCT03272503PIMOZIDEPHASE2ClinicalTrials.gov

1 to 10 of 28

See all 28 trials

NIH grants734

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDRD5 papersNewest fiscal year
ZIANS002263Molecular And Pharmacological Studies Of Dopamine Receptors92025
P50HD027802Differential Diagnosis in Learning Disabilities52025
R01MH112205Molecular Details of Psychoactive Drug Actions32025
R28AA012725Brain Tissue Resource Center for Alcohol Research32025
T32MH079785Interdisciplinary And Translational Research Training In Neurohiv32025
ZIAHG000175Genetic Analysis of Attention Deficit Hyperactivity Disorder32025
P20GM103427Nebraska Research Network in Functional Genomics22025
P30CA008748Cancer Center Support Grant22025
P30CA036727Buffett Cancer Center Support Grant22025
P30EY001583P30 Core Grant For Vision Research22025

1 to 10 of 734Source NIH's project files

See all 734 nih grants

Papers1,165

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Correlation of Aqueous Humor Dopamine with Axial Length and Its Regulation by TGFβ2 in Myopia.Curr Eye Res202642717484PubTator, text miningPubMed
Epigenetic regulation of inflammation by dopamine in primary human macrophages.Front Immunol202642433357PubTator, text miningPubMed
Dopamine receptors in ocular surface biology: Current evidence and future directions.Indian J Ophthalmol202642378568PubTator, text miningPubMed
Spatio-molecular gene expression reflects dorsal anterior cingulate cortex structure and function in the human brain.Cell Rep202642241279PubTator, text miningPubMed
Virtual and CMC-Based Screening Identified Reticuline, an Intermediate of BIA Biosynthesis, as a Potential Agonist of D5R.Molecules202642075963PubTator, text miningPubMed
Biomarker Variants of Dopamine Receptor Genes Influence the Binding Interaction Between Dopamine Receptor and Risperidone.Drug Des Devel Ther202642052100PubTator, text miningPubMed
Systematic review of the molecular basis for cavernous sinus invasion in somatotropinomas.Endocr Relat Cancer202641989873PubTator, text miningPubMed
Nuclear and membrane-bound hormone receptors in glioblastoma: Expression, functionality, and therapeutic implications.Neurooncol Adv202641768124PubTator, text miningPubMed
Driven by Dopamine: Genetic Insights into Motivation and Performance in Sports and Esports.Genes (Basel)202641751528PubTator, text miningPubMed
Epigenetic Regulation of Inflammation by Dopamine in Primary Human Macrophages.bioRxiv202641659543PubTator, text miningPubMed

1 to 10 of 1,165

See all 1,165 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1816

GET https://conductscience.org/api/genes/v1/1816/patents?page=2