Gene · 1816
DRD5: dopamine receptor D5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DRD5: dopamine receptor D5. Genes, record 1816. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1816
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P21918 | Dopamine receptor D5 | 477 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents40
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 44207 | P21918 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3945 | P21918 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1322 | P21918 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1322 | P21918 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3945 | P21918 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 25466 | P21918 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 257 | P21918 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 128437 | P21918 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 3264 | P21918 | Espacenet |
| KR 1020200143026 A | 2020-12-23 | 13 | P21918 | Espacenet |
1 to 10 of 40
See all 40 patentsDrugs7
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMOXAPINE | CHEMBL1113 | Dopamine receptor antagonist | ANTAGONIST | ChEMBL |
| ERGOLOID | CHEMBL2364968 | Dopamine receptor agonist | AGONIST | ChEMBL |
| ERGOLOID MESYLATES | CHEMBL2311030 | Dopamine receptor agonist | AGONIST | ChEMBL |
| PERGOLIDE | CHEMBL531 | Dopamine receptor agonist | AGONIST | ChEMBL |
| PERGOLIDE MESYLATE | CHEMBL1275 | Dopamine receptor agonist | AGONIST | ChEMBL |
| PIMOZIDE | CHEMBL1423 | Dopamine receptor antagonist | ANTAGONIST | ChEMBL |
| TAVAPADON | CHEMBL3697617 | Dopamine D5 receptor partial agonist | PARTIAL AGONIST | ChEMBL |
Trials28
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05610189 | TAVAPADON | PHASE1 | ClinicalTrials.gov | |
| NCT05507372 | PIMOZIDE | ClinicalTrials.gov | ||
| NCT05030129 | ERGOLOID MESYLATES | PHASE2 | 2024-09-19 | ClinicalTrials.gov |
| NCT04760769 | TAVAPADON | PHASE3 | ClinicalTrials.gov | |
| NCT04542499 | TAVAPADON | PHASE3 | 2025-03-25 | ClinicalTrials.gov |
| NCT04529226 | PIMOZIDE | PHASE2 | ClinicalTrials.gov | |
| NCT04295642 | TAVAPADON | PHASE1 | ClinicalTrials.gov | |
| NCT04223193 | TAVAPADON | PHASE3 | 2025-11-21 | ClinicalTrials.gov |
| NCT04201093 | TAVAPADON | PHASE3 | 2025-07-28 | ClinicalTrials.gov |
| NCT03272503 | PIMOZIDE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 28
See all 28 trialsNIH grants734
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DRD5 papers | Newest fiscal year |
|---|---|---|---|
| ZIANS002263 | Molecular And Pharmacological Studies Of Dopamine Receptors | 9 | 2025 |
| P50HD027802 | Differential Diagnosis in Learning Disabilities | 5 | 2025 |
| R01MH112205 | Molecular Details of Psychoactive Drug Actions | 3 | 2025 |
| R28AA012725 | Brain Tissue Resource Center for Alcohol Research | 3 | 2025 |
| T32MH079785 | Interdisciplinary And Translational Research Training In Neurohiv | 3 | 2025 |
| ZIAHG000175 | Genetic Analysis of Attention Deficit Hyperactivity Disorder | 3 | 2025 |
| P20GM103427 | Nebraska Research Network in Functional Genomics | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA036727 | Buffett Cancer Center Support Grant | 2 | 2025 |
| P30EY001583 | P30 Core Grant For Vision Research | 2 | 2025 |
1 to 10 of 734Source NIH's project files
See all 734 nih grantsPapers1,165
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Correlation of Aqueous Humor Dopamine with Axial Length and Its Regulation by TGFβ2 in Myopia. | Curr Eye Res | 2026 | 42717484 | PubTator, text mining | PubMed |
| Epigenetic regulation of inflammation by dopamine in primary human macrophages. | Front Immunol | 2026 | 42433357 | PubTator, text mining | PubMed |
| Dopamine receptors in ocular surface biology: Current evidence and future directions. | Indian J Ophthalmol | 2026 | 42378568 | PubTator, text mining | PubMed |
| Spatio-molecular gene expression reflects dorsal anterior cingulate cortex structure and function in the human brain. | Cell Rep | 2026 | 42241279 | PubTator, text mining | PubMed |
| Virtual and CMC-Based Screening Identified Reticuline, an Intermediate of BIA Biosynthesis, as a Potential Agonist of D5R. | Molecules | 2026 | 42075963 | PubTator, text mining | PubMed |
| Biomarker Variants of Dopamine Receptor Genes Influence the Binding Interaction Between Dopamine Receptor and Risperidone. | Drug Des Devel Ther | 2026 | 42052100 | PubTator, text mining | PubMed |
| Systematic review of the molecular basis for cavernous sinus invasion in somatotropinomas. | Endocr Relat Cancer | 2026 | 41989873 | PubTator, text mining | PubMed |
| Nuclear and membrane-bound hormone receptors in glioblastoma: Expression, functionality, and therapeutic implications. | Neurooncol Adv | 2026 | 41768124 | PubTator, text mining | PubMed |
| Driven by Dopamine: Genetic Insights into Motivation and Performance in Sports and Esports. | Genes (Basel) | 2026 | 41751528 | PubTator, text mining | PubMed |
| Epigenetic Regulation of Inflammation by Dopamine in Primary Human Macrophages. | bioRxiv | 2026 | 41659543 | PubTator, text mining | PubMed |
1 to 10 of 1,165
See all 1,165 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1816
GET https://conductscience.org/api/genes/v1/1816/patents?page=2