Gene · 186
AGTR2: angiotensin II receptor type 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. AGTR2: angiotensin II receptor type 2. Genes, record 186. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/186
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P50052 | Type-2 angiotensin II receptor | 363 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents33
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 37400 | P50052 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 351 | P50052 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 351 | P50052 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 4824 | P50052 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 4824 | P50052 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 201 | P50052 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 107795 | P50052 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 358 | P50052 | Espacenet |
| US 10772934 B2 | 2020-09-15 | 1148 | P50052 | Espacenet |
| US 10292374 B2 | 2019-05-21 | 286 | P50052 | Espacenet |
1 to 10 of 33
See all 33 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| OLODANRIGAN | CHEMBL34124 | Angiotensin II type 2 (AT-2) receptor antagonist | ANTAGONIST |
Source ChEMBL
Trials4
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT03297294 | OLODANRIGAN | PHASE2 | 2020-06-04 | ClinicalTrials.gov |
| NCT03094195 | OLODANRIGAN | PHASE2 | 2020-05-14 | ClinicalTrials.gov |
| NCT02435199 | OLODANRIGAN | PHASE2 | ClinicalTrials.gov | |
| NCT02426411 | OLODANRIGAN | PHASE2 | ClinicalTrials.gov |
NIH grants1,003
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | AGTR2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P20GM103418 | Kansas IDeA Network of Biomedical Research Excellence 5 | 3 | 2025 |
| P20GM121334 | Mississippi Center of Excellence in Perinatal Research, Phase 2 | 3 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 3 | 2025 |
| P30DK056341 | Washington University Nutrition Obesity Research Center | 3 | 2025 |
| R35GM127086 | Structural Biology Of G Protein-Coupled Receptors | 3 | 2025 |
| P30DK111024 | Georgia Center for Diabetes Translation Research | 2 | 2025 |
| R01DK044003 | Molecular Genetics of Cystic Fibrosis | 2 | 2025 |
| R01HL158548 | Novel Therapeutics for Cardiovascular Disease | 2 | 2025 |
| R01MH072567 | HIV-1 and amyloid beta interactions at the blood-brain barrier | 2 | 2025 |
1 to 10 of 1,003Source NIH's project files
See all 1,003 nih grantsPapers1,962
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Autoantibodies targeting G protein-coupled receptors and clinical outcome after ischemic stroke (PROSCIS-B). | J Neurol | 2026 | 42711567 | PubTator, text mining | PubMed |
| Higher Frontal Cortex Angiotensin Type 2 Receptor-Interacting Protein (ATIP) Levels Are Associated With a Lower Amyloid-Beta Burden in Postmortem Brains of Older Adults With Alzheimer's Disease. | Aging Cell | 2026 | 42669066 | PubTator, text mining | PubMed |
| Protective Arm of Renin-Angiotensin System: Evidence of Nephroprotective Effects Against Acute Kidney Injury. | Acta Physiol (Oxf) | 2026 | 42581377 | PubTator, text mining | PubMed |
| Combined Apocynin and Novokinin Treatment Attenuates Renal Damage and Reduces KIM-1 Expression in a Model of Ischemic AKI. | Int J Mol Sci | 2026 | 42511688 | PubTator, text mining | PubMed |
| Distinct conformational dynamics of the type-2 Angiotensin II receptor bound to Angiotensin II and Angiotensin (1-7). | Sci Rep | 2026 | 42477346 | PubTator, text mining | PubMed |
| Developmental and Structural Alterations at the Ductus-Aortic Isthmus Interface in Infantile Coarctation of the Aorta: A Biological Basis for Persistent Vascular Disease Beyond Anatomical Repair. | J Clin Med | 2026 | 42452674 | PubTator, text mining | PubMed |
| Beneficial effects of the AT2 receptor agonist buloxibutid (C21) against acute alveolar epithelial cell inflammation during antiviral responses. | ERJ Open Res | 2026 | 42440724 | PubTator, text mining | PubMed |
| Genetics of hypertension in populations affected by the Aral Sea ecological crisis: A case-control study. | PLoS One | 2026 | 42406770 | PubTator, text mining | PubMed |
| Neurotherapeutic roles of the protective arm of the renin-angiotensin system: from inflammation to cognitive rescue. | Mol Biol Rep | 2026 | 42364023 | PubTator, text mining | PubMed |
| Dexamethasone as a Modulator of Renin-Angiotensin System Receptor Expression in Prostate and Ovarian Cancer Cells Under Standard and Low-Serum Conditions. | Cancers (Basel) | 2026 | 42352530 | PubTator, text mining | PubMed |
1 to 10 of 1,962
See all 1,962 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/186
GET https://conductscience.org/api/genes/v1/186/patents?page=2