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Gene · 186

AGTR2: angiotensin II receptor type 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AGTR2: angiotensin II receptor type 2. Genes, record 186. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/186

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Gene

Symbol
AGTR2
HGNC
Name
angiotensin II receptor type 2
HGNC
NCBI Gene ID
186
NCBI Gene
HGNC ID
HGNC:338
HGNC
Ensembl
ENSG00000180772
NCBI Gene
Aliases
AT2, ATGR2, MRX88
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P50052Type-2 angiotensin II receptor3637Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437400P50052Espacenet
JP 2025529142 A2025-09-04351P50052Espacenet
US 12371689 B22025-07-29351P50052Espacenet
JP 2025062604 A2025-04-144824P50052Espacenet
US 11446398 B22022-09-204824P50052Espacenet
US 11400116 B22022-08-02201P50052Espacenet
JP 2022524081 A2022-04-27107795P50052Espacenet
US 11078247 B22021-08-03358P50052Espacenet
US 10772934 B22020-09-151148P50052Espacenet
US 10292374 B22019-05-21286P50052Espacenet

1 to 10 of 33

See all 33 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
OLODANRIGANCHEMBL34124Angiotensin II type 2 (AT-2) receptor antagonistANTAGONIST

Source ChEMBL

Trials4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03297294OLODANRIGANPHASE22020-06-04ClinicalTrials.gov
NCT03094195OLODANRIGANPHASE22020-05-14ClinicalTrials.gov
NCT02435199OLODANRIGANPHASE2ClinicalTrials.gov
NCT02426411OLODANRIGANPHASE2ClinicalTrials.gov

NIH grants1,003

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAGTR2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant52025
P20GM103418Kansas IDeA Network of Biomedical Research Excellence 532025
P20GM121334Mississippi Center of Excellence in Perinatal Research, Phase 232025
P30CA091842Cancer Center Support Grant32025
P30DK056341Washington University Nutrition Obesity Research Center32025
R35GM127086Structural Biology Of G Protein-Coupled Receptors32025
P30DK111024Georgia Center for Diabetes Translation Research22025
R01DK044003Molecular Genetics of Cystic Fibrosis22025
R01HL158548Novel Therapeutics for Cardiovascular Disease22025
R01MH072567HIV-1 and amyloid beta interactions at the blood-brain barrier22025

1 to 10 of 1,003Source NIH's project files

See all 1,003 nih grants

Papers1,962

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Autoantibodies targeting G protein-coupled receptors and clinical outcome after ischemic stroke (PROSCIS-B).J Neurol202642711567PubTator, text miningPubMed
Higher Frontal Cortex Angiotensin Type 2 Receptor-Interacting Protein (ATIP) Levels Are Associated With a Lower Amyloid-Beta Burden in Postmortem Brains of Older Adults With Alzheimer's Disease.Aging Cell202642669066PubTator, text miningPubMed
Protective Arm of Renin-Angiotensin System: Evidence of Nephroprotective Effects Against Acute Kidney Injury.Acta Physiol (Oxf)202642581377PubTator, text miningPubMed
Combined Apocynin and Novokinin Treatment Attenuates Renal Damage and Reduces KIM-1 Expression in a Model of Ischemic AKI.Int J Mol Sci202642511688PubTator, text miningPubMed
Distinct conformational dynamics of the type-2 Angiotensin II receptor bound to Angiotensin II and Angiotensin (1-7).Sci Rep202642477346PubTator, text miningPubMed
Developmental and Structural Alterations at the Ductus-Aortic Isthmus Interface in Infantile Coarctation of the Aorta: A Biological Basis for Persistent Vascular Disease Beyond Anatomical Repair.J Clin Med202642452674PubTator, text miningPubMed
Beneficial effects of the AT2 receptor agonist buloxibutid (C21) against acute alveolar epithelial cell inflammation during antiviral responses.ERJ Open Res202642440724PubTator, text miningPubMed
Genetics of hypertension in populations affected by the Aral Sea ecological crisis: A case-control study.PLoS One202642406770PubTator, text miningPubMed
Neurotherapeutic roles of the protective arm of the renin-angiotensin system: from inflammation to cognitive rescue.Mol Biol Rep202642364023PubTator, text miningPubMed
Dexamethasone as a Modulator of Renin-Angiotensin System Receptor Expression in Prostate and Ovarian Cancer Cells Under Standard and Low-Serum Conditions.Cancers (Basel)202642352530PubTator, text miningPubMed

1 to 10 of 1,962

See all 1,962 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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