ConductScience.org, home

Gene · 1903

S1PR3: sphingosine-1-phosphate receptor 3

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. S1PR3: sphingosine-1-phosphate receptor 3. Genes, record 1903. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1903

On this page

Gene

Symbol
S1PR3
HGNC
Name
sphingosine-1-phosphate receptor 3
HGNC
NCBI Gene ID
1903
NCBI Gene
HGNC ID
HGNC:3167
HGNC
Ensembl
ENSG00000213694
NCBI Gene
Aliases
C9orf108, C9orf47, EDG-3, EDG3, FLJ37523, LPB3, S1P3, bA791O21.3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99500Sphingosine 1-phosphate receptor 33789Ensembl, GeneID, HGNC

Source UniProt

Patents83

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1054Q99500Espacenet
JP 2026004568 A2026-01-1465286Q99500Espacenet
JP 2026004568 A2026-01-1465287Q99500Espacenet
EP 4650780 A22025-11-197510Q99500Espacenet
JP 2025529142 A2025-09-043812Q99500Espacenet
US 12371689 B22025-07-293812Q99500Espacenet
JP 2025517970 A2025-06-127510Q99500Espacenet
EP 4471152 A22024-12-0417Q99500Espacenet
JP 2023156353 A2023-10-2454Q99500Espacenet
US 11708610 B22023-07-25891Q99500Espacenet

1 to 10 of 83

See all 83 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMISELIMODCHEMBL3707375Sphingosine 1-phosphate receptor modulatorMODULATORChEMBL
AMISELIMOD HYDROCHLORIDECHEMBL3707374Sphingosine 1-phosphate receptor modulatorMODULATORChEMBL
FINGOLIMODCHEMBL314854Sphingosine 1-phosphate receptor agonistAGONISTChEMBL
FINGOLIMODCHEMBL314854Sphingosine 1-phosphate receptor binding agentBINDING AGENTChEMBL
FINGOLIMOD HYDROCHLORIDECHEMBL544665Sphingosine 1-phosphate receptor agonistAGONISTChEMBL
FINGOLIMOD LAURYL SULFATECHEMBL5095050Sphingosine 1-phosphate receptor binding agentBINDING AGENTChEMBL

Trials83

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07483632FINGOLIMODPHASE3ClinicalTrials.gov
NCT07220252FINGOLIMODPHASE2/PHASE3ClinicalTrials.gov
NCT06424067FINGOLIMODPHASE2ClinicalTrials.gov
NCT06408259FINGOLIMODPHASE3ClinicalTrials.gov
NCT06087965FINGOLIMODPHASE1/PHASE2ClinicalTrials.gov
NCT05762003FINGOLIMODClinicalTrials.gov
NCT05423769FINGOLIMODClinicalTrials.gov
NCT05141669FINGOLIMODClinicalTrials.gov
NCT05123703FINGOLIMODPHASE3ClinicalTrials.gov
NCT04857112AMISELIMODPHASE2ClinicalTrials.gov

1 to 10 of 83

See all 83 trials

NIH grants1,137

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleS1PR3 papersNewest fiscal year
P01CA097132Sphingolipids in Cancer Biology and Therapy202025
P01HL126609Cytoskeletal Regulation of Lung Endothelial Pathobiology in ARDS92025
P30CA016059Massey Cancer Center - Cancer Center Support Grant52025
T32HL007829Training Program in Lung Biology and Pathobiology52025
P30CA008748Cancer Center Support Grant42025
P30CA016056Roswell Park Cancer Center Support Grant42025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)42025
R01DE016572Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and Therapy42025
IK6BX004477BLR&D Research Career Scientist Award Application32025

1 to 10 of 1,137Source NIH's project files

See all 1,137 nih grants

Papers1,892

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Effects of sphingosine-1-phosphate receptor modulators on remyelination in multiple sclerosis: evidence from in vitro experiments, animal models and human studies.Front Immunol202642780639PubTator, text miningPubMed
HMOX2-driven crosstalk between vascular aging and heart failure: A multimodal bioinformatics and explainable machine learning approach with experimental validation.PLoS One202642743238PubTator, text miningPubMed
Sphingosine 1-phosphate signalling contributes to transforming growth factor-β1-induced myofibroblast differentiation in oral cancer.PeerJ202642730290PubTator, text miningPubMed
Endothelial S1PR3 downregulation exacerbates pressure overload-induced cardiac remodeling by promoting fibrosis and inflammation.Sci China Life Sci202642726410PubTator, text miningPubMed
Novel brominated flame retardant TBPH upregulates thyroid synthesis markers via S1PR3 and involves IL-10 with atypical JAK-STAT activation.Environ Res202642722097PubTator, text miningPubMed
C/EBPδ regulates SPHK1-dependent excessive autophagy in decidualization defects of chronic endometritis.Reproduction202642704675PubTator, text miningPubMed
Fungal Infections Associated with Sphingosine 1-Phosphate Receptor Modulators: Immunological Mechanisms, Clinical Patterns, and Management Considerations.Microorganisms202642655205PubTator, text miningPubMed
A self-sustaining hypoxia inducible factor-1α-creatine kinase B feedforward circuit drives macrophage-mediated kidney fibrosis.Kidney Int202642628836PubTator, text miningPubMed
Isorhoifolin regulates S1PR3-CK2-GSK3β axis and promotes neurite regrowth and functional recovery after traumatic brain injury.Phytomedicine202642604624PubTator, text miningPubMed
Treatment effects on sphingosine-1-phosphate and its receptors in major depressive disorder: implications for biomarkers.BMC Psychiatry202642527914PubTator, text miningPubMed

1 to 10 of 1,892

See all 1,892 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1903

GET https://conductscience.org/api/genes/v1/1903/patents?page=2