Gene · 2104
ESRRG: estrogen related receptor gamma
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ESRRG: estrogen related receptor gamma. Genes, record 2104. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2104
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P62508 | Estrogen-related receptor gamma | 458 | 43 | Ensembl, GeneID, HGNC |
Source UniProt
Patents60
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026076236 A | 2026-05-11 | 47 | P62508 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 45305 | P62508 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 12880 | P62508 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 14945 | P62508 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 12880 | P62508 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 27962 | P62508 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 14945 | P62508 | Espacenet |
| US 12213999 B2 | 2025-02-04 | 1 | P62508 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 14945 | P62508 | Espacenet |
| US 12168778 B2 | 2024-12-17 | 47 | P62508 | Espacenet |
1 to 10 of 60
See all 60 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| AFIMOXIFENE | CHEMBL489 | Estrogen-related receptor gamma antagonist | ANTAGONIST |
Source ChEMBL
Trials2
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04009044 | AFIMOXIFENE | PHASE2 | ClinicalTrials.gov | |
| NCT02993159 | AFIMOXIFENE | PHASE2 | 2024-12-18 | ClinicalTrials.gov |
NIH grants1,380
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ESRRG papers | Newest fiscal year |
|---|---|---|---|
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 11 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 8 | 2025 |
| T32CA009686 | Training Grant In Tumor Biology | 8 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 7 | 2025 |
| P30ES017885 | Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) | 7 | 2025 |
| P30DK019525 | University of Pennsylvania Diabetes Research Center | 5 | 2025 |
| P30DK056341 | Washington University Nutrition Obesity Research Center | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| R01AI045050 | Characterization of SLE-susceptibility loci on mouse chromosome 1 | 4 | 2025 |
| R01HL057181 | Cardiogenesis: Molecular Mechanisms | 4 | 2025 |
1 to 10 of 1,380Source NIH's project files
See all 1,380 nih grantsPapers1,736
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Convolvulus althaeoides as a Potential Natural Source in Cancer Prophylaxis and Treatment: LC-ESI-MS/MS, GC-MS, In Vitro, and In Silico Investigations. | Chem Biodivers | 2026 | 42814524 | PubTator, text mining | PubMed |
| Histone demethylase KDM4A promotes endometrial cancer progression through an ERRγ-associated cell-cycle regulatory axis. | Int J Biol Sci | 2026 | 42807380 | PubTator, text mining | PubMed |
| Stable simulations do not guarantee functional engagement: a case study of off-target prediction for Seladelpar and Zanamivir. | J Comput Aided Mol Des | 2026 | 42690469 | PubTator, text mining | PubMed |
| Screening of core targets for Di(2-ethylhexyl) Phthalate-related gastric cancer based on machine learning, molecular docking, and SHAP analysis. | PLoS Comput Biol | 2026 | 42461936 | PubTator, text mining | PubMed |
| Estrogen-related receptor γ functions as a novel corepressor of androgen receptor by destabilizing receptor conformation and blocking coactivator recruitment. | J Biochem | 2026 | 42383774 | PubTator, text mining | PubMed |
| Identification and Prognostic Analysis of Immune-Related Genes Co-Regulated by Key Histone Modifications in Breast Cancer. | Curr Issues Mol Biol | 2026 | 42353587 | PubTator, text mining | PubMed |
| Pharmacology of estrogen-related receptors (ERRs) agonists. | RSC Chem Biol | 2026 | 42256350 | PubTator, text mining | PubMed |
| Multimechanistic actions of functional factors in enhancing physical strength and endurance: a scoping review of nutritional basis and natural extracts. | Front Sports Act Living | 2026 | 42211549 | PubTator, text mining | PubMed |
| Reduced HSD17B1 expression in preeclampsia: integrated transcriptomic, summary Mendelian randomization, immune deconvolution, and experimental validation. | BMC Pregnancy Childbirth | 2026 | 42210128 | PubTator, text mining | PubMed |
| Scale-Up Isolation of High-Purity Shatavarins from Asparagus racemosus via Flash Chromatography with Bioavailability and Pharmacological Insights. | ACS Omega | 2026 | 41970898 | PubTator, text mining | PubMed |
1 to 10 of 1,736
See all 1,736 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2104
GET https://conductscience.org/api/genes/v1/2104/patents?page=2