Gene · 2243
FGA: fibrinogen alpha chain
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FGA: fibrinogen alpha chain. Genes, record 2243. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2243
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P02671 | Fibrinogen alpha chain | 866 | 39 | Ensembl, GeneID, HGNC |
Source UniProt
Patents136
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12560619 B2 | 2026-02-24 | 115 | P02671 | Espacenet |
| US 12544451 B2 | 2026-02-10 | 2 | P02671 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 19713 | P02671 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 971 | P02671 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 4100 | P02671 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 25597 | P02671 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 5266 | P02671 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6366 | P02671 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6366 | P02671 | Espacenet |
| JP 2025519280 A | 2025-06-25 | 2 | P02671 | Espacenet |
1 to 10 of 136
See all 136 patentsDrugs5
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ALFIMEPRASE | CHEMBL2108893 | Fibrinogen hydrolytic enzyme | HYDROLYTIC ENZYME | ChEMBL |
| ANCROD | CHEMBL2108481 | Fibrinogen hydrolytic enzyme | HYDROLYTIC ENZYME | ChEMBL |
| FIBRINOGEN, HUMAN | CHEMBL2109072 | Fibrinogen exogenous protein | EXOGENOUS PROTEIN | ChEMBL |
| FIBRINOLYSIN, HUMAN | CHEMBL1201505 | Fibrinogen inhibitor | INHIBITOR | ChEMBL |
| PLASMINOGEN | CHEMBL2108131 | Fibrinogen hydrolytic enzyme | HYDROLYTIC ENZYME | ChEMBL |
Trials40
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07425600 | FIBRINOGEN, HUMAN | ClinicalTrials.gov | ||
| NCT06617897 | FIBRINOGEN, HUMAN | PHASE3 | ClinicalTrials.gov | |
| NCT06381661 | PLASMINOGEN | PHASE2 | ClinicalTrials.gov | |
| NCT05717335 | FIBRINOGEN, HUMAN | ClinicalTrials.gov | ||
| NCT04636268 | FIBRINOGEN, HUMAN | PHASE3 | ClinicalTrials.gov | |
| NCT04586062 | PLASMINOGEN | ClinicalTrials.gov | ||
| NCT04275232 | PLASMINOGEN | PHASE3 | ClinicalTrials.gov | |
| NCT03932240 | FIBRINOGEN, HUMAN | PHASE3 | 2023-03-20 | ClinicalTrials.gov |
| NCT03784794 | FIBRINOGEN, HUMAN | ClinicalTrials.gov | ||
| NCT03642691 | PLASMINOGEN | ClinicalTrials.gov |
1 to 10 of 40
See all 40 trialsNIH grants1,534
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FGA papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 11 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 11 | 2025 |
| R01HL056051 | Fibrin(ogen) Structure and Interactions | 11 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 9 | 2025 |
| ZIAHL006170 | Cardiovascular Genomics and Bioinformatics projects | 6 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 5 | 2025 |
| ZICHL005907 | NHLBI Transgenic Core | 5 | 2025 |
| ZICHL006145 | NHLBI iPSC Core Facility | 5 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 4 | 2025 |
1 to 10 of 1,534Source NIH's project files
See all 1,534 nih grantsPapers3,650
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| From Machine Learning-Enhanced Proteomics to a Validated Diagnostic Model: A Pipeline for Breast Cancer Biomarker Discovery via Independent and Transcriptomic Corroboration. | Bioengineering (Basel) | 2026 | 42791912 | PubTator, text mining | PubMed |
| Compound Heterozygous Mutations in FGA Cause Congenital Afibrinogenemia: A Case Report and Literature Review. | Birth Defects Res | 2026 | 42757861 | PubTator, text mining | PubMed |
| A novel Mutation p.Thr308Asn in the Snout-like Region of the Fibrinogen Bβ Chain: Analysis of the Pathogenic Mechanism of Hereditary Hypofibrinogenemia. | Hamostaseologie | 2026 | 42648660 | PubTator, text mining | PubMed |
| A Molecular Tool Set for Measurement of Lung Cancer-Associated Protein Biomarker CIZ1B-FibA in Human Plasma. | J Appl Lab Med | 2026 | 42616406 | PubTator, text mining | PubMed |
| Protein signatures for the early detection of endometrial cancer in cervico-vaginal fluid. | Expert Rev Mol Diagn | 2026 | 42460670 | PubTator, text mining | PubMed |
| Genetic mutation patterns in Indonesian children with primary steroid-resistant nephrotic syndrome. | Pediatr Nephrol | 2026 | 42420527 | PubTator, text mining | PubMed |
| Deep Dive into Evolution: How Cetaceans Adapt Their Anticoagulant Genes for Underwater Survival. | J Mol Evol | 2026 | 42406052 | PubTator, text mining | PubMed |
| An exploratory study of BLCA-4 expression, STR analysis, and urothelial cytology in smokers versus non-smokers with bladder cancer. | Front Oncol | 2026 | 42388612 | PubTator, text mining | PubMed |
| Hypofibrinogenemia caused by a heterozygous variant in the FGA gene: a case report. | Thromb J | 2026 | 42323625 | PubTator, text mining | PubMed |
| A bioinformatics and experimental approach identifies glycoprotein-based diagnostic and prognostic biomarkers for colon adenocarcinoma. | Sci Rep | 2026 | 42151258 | PubTator, text mining | PubMed |
1 to 10 of 3,650
See all 3,650 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2243
GET https://conductscience.org/api/genes/v1/2243/patents?page=2