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Gene · 2243

FGA: fibrinogen alpha chain

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FGA: fibrinogen alpha chain. Genes, record 2243. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2243

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Gene

Symbol
FGA
HGNC
Name
fibrinogen alpha chain
HGNC
NCBI Gene ID
2243
NCBI Gene
HGNC ID
HGNC:3661
HGNC
Ensembl
ENSG00000171560
NCBI Gene
Aliases
AMYLD2, Fib2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P02671Fibrinogen alpha chain86639Ensembl, GeneID, HGNC

Source UniProt

Patents136

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12560619 B22026-02-24115P02671Espacenet
US 12544451 B22026-02-102P02671Espacenet
EP 4650780 A22025-11-1919713P02671Espacenet
JP 2025169942 A2025-11-14971P02671Espacenet
EP 4640849 A22025-10-294100P02671Espacenet
EP 4641201 A22025-10-2925597P02671Espacenet
JP 2025147176 A2025-10-065266P02671Espacenet
JP 2025529142 A2025-09-046366P02671Espacenet
US 12371689 B22025-07-296366P02671Espacenet
JP 2025519280 A2025-06-252P02671Espacenet

1 to 10 of 136

See all 136 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALFIMEPRASECHEMBL2108893Fibrinogen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
ANCRODCHEMBL2108481Fibrinogen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
FIBRINOGEN, HUMANCHEMBL2109072Fibrinogen exogenous proteinEXOGENOUS PROTEINChEMBL
FIBRINOLYSIN, HUMANCHEMBL1201505Fibrinogen inhibitorINHIBITORChEMBL
PLASMINOGENCHEMBL2108131Fibrinogen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL

Trials40

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07425600FIBRINOGEN, HUMANClinicalTrials.gov
NCT06617897FIBRINOGEN, HUMANPHASE3ClinicalTrials.gov
NCT06381661PLASMINOGENPHASE2ClinicalTrials.gov
NCT05717335FIBRINOGEN, HUMANClinicalTrials.gov
NCT04636268FIBRINOGEN, HUMANPHASE3ClinicalTrials.gov
NCT04586062PLASMINOGENClinicalTrials.gov
NCT04275232PLASMINOGENPHASE3ClinicalTrials.gov
NCT03932240FIBRINOGEN, HUMANPHASE32023-03-20ClinicalTrials.gov
NCT03784794FIBRINOGEN, HUMANClinicalTrials.gov
NCT03642691PLASMINOGENClinicalTrials.gov

1 to 10 of 40

See all 40 trials

NIH grants1,534

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFGA papersNewest fiscal year
P30CA008748Cancer Center Support Grant112025
P30CA046934University of Colorado Cancer Center Support Grant112025
R01HL056051Fibrin(ogen) Structure and Interactions112025
P30CA016672Cancer Center Support Grant92025
P30DK063491Diabetes Research Center (DRC)92025
ZIAHL006170Cardiovascular Genomics and Bioinformatics projects62025
P30CA021765Cancer Center Support Grant (CCSG)52025
ZICHL005907NHLBI Transgenic Core52025
ZICHL006145NHLBI iPSC Core Facility52025
P30CA014051Cancer Center Support (Core) Grant42025

1 to 10 of 1,534Source NIH's project files

See all 1,534 nih grants

Papers3,650

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
From Machine Learning-Enhanced Proteomics to a Validated Diagnostic Model: A Pipeline for Breast Cancer Biomarker Discovery via Independent and Transcriptomic Corroboration.Bioengineering (Basel)202642791912PubTator, text miningPubMed
Compound Heterozygous Mutations in FGA Cause Congenital Afibrinogenemia: A Case Report and Literature Review.Birth Defects Res202642757861PubTator, text miningPubMed
A novel Mutation p.Thr308Asn in the Snout-like Region of the Fibrinogen Bβ Chain: Analysis of the Pathogenic Mechanism of Hereditary Hypofibrinogenemia.Hamostaseologie202642648660PubTator, text miningPubMed
A Molecular Tool Set for Measurement of Lung Cancer-Associated Protein Biomarker CIZ1B-FibA in Human Plasma.J Appl Lab Med202642616406PubTator, text miningPubMed
Protein signatures for the early detection of endometrial cancer in cervico-vaginal fluid.Expert Rev Mol Diagn202642460670PubTator, text miningPubMed
Genetic mutation patterns in Indonesian children with primary steroid-resistant nephrotic syndrome.Pediatr Nephrol202642420527PubTator, text miningPubMed
Deep Dive into Evolution: How Cetaceans Adapt Their Anticoagulant Genes for Underwater Survival.J Mol Evol202642406052PubTator, text miningPubMed
An exploratory study of BLCA-4 expression, STR analysis, and urothelial cytology in smokers versus non-smokers with bladder cancer.Front Oncol202642388612PubTator, text miningPubMed
Hypofibrinogenemia caused by a heterozygous variant in the FGA gene: a case report.Thromb J202642323625PubTator, text miningPubMed
A bioinformatics and experimental approach identifies glycoprotein-based diagnostic and prognostic biomarkers for colon adenocarcinoma.Sci Rep202642151258PubTator, text miningPubMed

1 to 10 of 3,650

See all 3,650 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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