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Gene · 2266

FGG: fibrinogen gamma chain

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FGG: fibrinogen gamma chain. Genes, record 2266. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2266

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Gene

Symbol
FGG
HGNC
Name
fibrinogen gamma chain
HGNC
NCBI Gene ID
2266
NCBI Gene
HGNC ID
HGNC:3694
HGNC
Ensembl
ENSG00000171557
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P02679Fibrinogen gamma chain45347Ensembl, GeneID, HGNC

Source UniProt

Patents131

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4663754 A22025-12-1714P02679Espacenet
EP 4650780 A22025-11-196229P02679Espacenet
JP 2025169942 A2025-11-14976P02679Espacenet
EP 4641201 A22025-10-295988P02679Espacenet
JP 2025147176 A2025-10-065371P02679Espacenet
JP 2025529142 A2025-09-046388P02679Espacenet
US 12371689 B22025-07-296388P02679Espacenet
JP 2025519280 A2025-06-255P02679Espacenet
JP 2025517969 A2025-06-125988P02679Espacenet
JP 2025517970 A2025-06-126229P02679Espacenet

1 to 10 of 131

See all 131 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALFIMEPRASECHEMBL2108893Fibrinogen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
ANCRODCHEMBL2108481Fibrinogen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
FIBRINOGEN, HUMANCHEMBL2109072Fibrinogen exogenous proteinEXOGENOUS PROTEINChEMBL
FIBRINOLYSIN, HUMANCHEMBL1201505Fibrinogen inhibitorINHIBITORChEMBL
PLASMINOGENCHEMBL2108131Fibrinogen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL

Trials40

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07425600FIBRINOGEN, HUMANClinicalTrials.gov
NCT06617897FIBRINOGEN, HUMANPHASE3ClinicalTrials.gov
NCT06381661PLASMINOGENPHASE2ClinicalTrials.gov
NCT05717335FIBRINOGEN, HUMANClinicalTrials.gov
NCT04636268FIBRINOGEN, HUMANPHASE3ClinicalTrials.gov
NCT04586062PLASMINOGENClinicalTrials.gov
NCT04275232PLASMINOGENPHASE3ClinicalTrials.gov
NCT03932240FIBRINOGEN, HUMANPHASE32023-03-20ClinicalTrials.gov
NCT03784794FIBRINOGEN, HUMANClinicalTrials.gov
NCT03642691PLASMINOGENClinicalTrials.gov

1 to 10 of 40

See all 40 trials

NIH grants1,352

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFGG papersNewest fiscal year
P30DK063491Diabetes Research Center (DRC)102025
ZIAHL006170Cardiovascular Genomics and Bioinformatics projects82025
R01HL056051Fibrin(ogen) Structure and Interactions62025
P30CA093373Cancer Center Support Grant P3042025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease42025
P30DK120531Pittsburgh Liver Research Center42025
R01HL034594RISK FACTORS FOR CVD IN WOMEN42025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal42025
T32GM008315Mechanisms of Trauma-Induced Coagulopathy42025
T32HL007779Cardiovascular Disease Epidemiology & Prevention42025

1 to 10 of 1,352Source NIH's project files

See all 1,352 nih grants

Papers2,467

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A novel Mutation p.Thr308Asn in the Snout-like Region of the Fibrinogen Bβ Chain: Analysis of the Pathogenic Mechanism of Hereditary Hypofibrinogenemia.Hamostaseologie202642648660PubTator, text miningPubMed
Multi-omics analysis identifies a hepatocyte-associated signature in alcohol-related liver injury.Front Immunol202642558149PubTator, text miningPubMed
Phenotypic and glycosylation profiles of the FGG c.902G > A (p.Arg301His) mutation in a Chinese pedigree with congenital dysfibrinogenemia.Thromb Res202642551304PubTator, text miningPubMed
Genetic associations with pulmonary embolism among those with a deep vein thrombosis: the International Network Against Venous Thrombosis Consortium.J Thromb Haemost202642508647PubTator, text miningPubMed
miR-320d Is Associated with Reduced Nasopharyngeal Carcinoma Progression, Potentially through the NF-κB/IL-8 Axis-Mediated Inhibition of Neutrophil Extracellular Trap Formation.Oncol Res202642500573PubTator, text miningPubMed
Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen-Integrin Activation and Local MSU Crystallization.Adv Sci (Weinh)202642439437PubTator, text miningPubMed
Quantitative Proteomic Profiling of Plasma Alterations Associated with Thrombotic Risk and Insulin Resistance in Type 1 Diabetes.Thromb Haemost202642431204PubTator, text miningPubMed
Deep Dive into Evolution: How Cetaceans Adapt Their Anticoagulant Genes for Underwater Survival.J Mol Evol202642406052PubTator, text miningPubMed
Too Common to Ignore: Decoding the Complexity of the FGG p.Ala108Gly Variant in Fibrinogen Disorders.Hamostaseologie202642331027PubTator, text miningPubMed
Circadian-immune-related gene signature for lung squamous cell carcinoma: machine learning and multi-omics analysis.Transl Cancer Res202642305521PubTator, text miningPubMed

1 to 10 of 2,467

See all 2,467 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2266

GET https://conductscience.org/api/genes/v1/2266/patents?page=2