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Gene · 2339

FNTA: farnesyltransferase, CAAX box, subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FNTA: farnesyltransferase, CAAX box, subunit alpha. Genes, record 2339. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2339

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Gene

Symbol
FNTA
HGNC
Name
farnesyltransferase, CAAX box, subunit alpha
HGNC
NCBI Gene ID
2339
NCBI Gene
HGNC ID
HGNC:3782
HGNC
Ensembl
ENSG00000168522
NCBI Gene
Aliases
FPTA, PGGT1A, PTAR2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49354Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha37914Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445872P49354Espacenet
EP 4650780 A22025-11-194211P49354Espacenet
EP 4641201 A22025-10-293766P49354Espacenet
JP 2025517969 A2025-06-123766P49354Espacenet
JP 2025517970 A2025-06-124211P49354Espacenet
US 11446398 B22022-09-2030729P49354Espacenet
JP 2022524081 A2022-04-27133700P49354Espacenet
US 11078247 B22021-08-034121P49354Espacenet
EP 3504344 A12019-07-031186P49354Espacenet
JP 2019054813 A2019-04-11226307P49354Espacenet

1 to 10 of 25

See all 25 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LONAFARNIBCHEMBL298734Protein farnesyltransferase inhibitorINHIBITORChEMBL
TIPIFARNIBCHEMBL289228Protein farnesyltransferase inhibitorINHIBITORChEMBL

Trials110

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06775041LONAFARNIBPHASE2ClinicalTrials.gov
NCT06540963TIPIFARNIBPHASE2ClinicalTrials.gov
NCT05953545LONAFARNIBPHASE2ClinicalTrials.gov
NCT05693090TIPIFARNIBPHASE1ClinicalTrials.gov
NCT05229991LONAFARNIBPHASE3ClinicalTrials.gov
NCT04997902TIPIFARNIBPHASE1/PHASE2ClinicalTrials.gov
NCT04809233TIPIFARNIBClinicalTrials.gov
NCT04284774TIPIFARNIBPHASE22025-06-03ClinicalTrials.gov
NCT03895528LONAFARNIBClinicalTrials.gov
NCT03719690TIPIFARNIBPHASE22024-06-21ClinicalTrials.gov

1 to 10 of 110

See all 110 trials

NIH grants281

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFNTA papersNewest fiscal year
P30CA016672Cancer Center Support Grant22025
P50HD103538Intellectual and Developmental Disabilities Research Centers22025
P01CA092584Structural Cell Biology of DNA Repair Machines12025
P01HL114501Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers12025
P30AI060354Harvard University Center for AIDS Research12025
P30CA008748Cancer Center Support Grant12025
P30CA015704Cancer Center Support Grant12025
P30CA016059Massey Cancer Center - Cancer Center Support Grant12025
P30CA016086Cancer Center Support Grant12025
P30CA016087Cancer Center Support Grant12025

1 to 10 of 281Source NIH's project files

See all 281 nih grants

Papers333

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Downregulation of prenylation machinery genes in peripheral blood of patients with Parkinson's disease: A pilot study.IBRO Neurosci Rep202642775007PubTator, text miningPubMed
High yield production of C-terminally processed KRAS4a, HRAS, and NRAS for biophysical study.Protein Expr Purif202642142681PubTator, text miningPubMed
CpG Methylation of Protein Prenyltransferase Genes FNTA, FNTB, PGGT1B and RABGGTA in Cancer Cell Lines.Epigenomes202641892366PubTator, text miningPubMed
Farnesyltransferase inhibitor LB42708 disables oncogenic RAS signaling and overcomes gefitinib resistance in NSCLC via FTase α-subunit and RAS degradation.Cell Commun Signal202641821004PubTator, text miningPubMed
IgRENE: integrating gene regulatory networks and drug ontologies towards selected modification of target gene's expression.Brief Bioinform202541405964PubTator, text miningPubMed
SCORCH2: A Generalized Heterogeneous Consensus Model for High-Enrichment Interaction-Based Virtual Screening.Adv Sci (Weinh)202540832726PubTator, text miningPubMed
The impact of sarcopenia on prognosis and fruquintinib efficacy in advanced colorectal cancer: a retrospective and mendelian randomization study.Front Immunol202540740773PubTator, text miningPubMed
Significant upregulation of prenyltransferase-related genes in neuromyelitis optica: Diagnostic potential and clinical correlations.Mult Scler Relat Disord202540712510PubTator, text miningPubMed
METTL3 Promotes Gastric Cancer Progression via Modulation of FNTA-Mediated KRAS/ERK Signaling Activation.Mol Cancer Res202540353746PubTator, text miningPubMed
Exploring the potential of compound-protein complex structure-free models in virtual screening using BlendNet.Brief Bioinform202439804143PubTator, text miningPubMed

1 to 10 of 333

See all 333 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2339

GET https://conductscience.org/api/genes/v1/2339/patents?page=2