Gene · 2339
FNTA: farnesyltransferase, CAAX box, subunit alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FNTA: farnesyltransferase, CAAX box, subunit alpha. Genes, record 2339. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2339
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49354 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | 379 | 14 | Ensembl, GeneID, HGNC |
Source UniProt
Patents25
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 45872 | P49354 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4211 | P49354 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3766 | P49354 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3766 | P49354 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4211 | P49354 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 30729 | P49354 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 133700 | P49354 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 4121 | P49354 | Espacenet |
| EP 3504344 A1 | 2019-07-03 | 1186 | P49354 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 226307 | P49354 | Espacenet |
1 to 10 of 25
See all 25 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials110
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06775041 | LONAFARNIB | PHASE2 | ClinicalTrials.gov | |
| NCT06540963 | TIPIFARNIB | PHASE2 | ClinicalTrials.gov | |
| NCT05953545 | LONAFARNIB | PHASE2 | ClinicalTrials.gov | |
| NCT05693090 | TIPIFARNIB | PHASE1 | ClinicalTrials.gov | |
| NCT05229991 | LONAFARNIB | PHASE3 | ClinicalTrials.gov | |
| NCT04997902 | TIPIFARNIB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT04809233 | TIPIFARNIB | ClinicalTrials.gov | ||
| NCT04284774 | TIPIFARNIB | PHASE2 | 2025-06-03 | ClinicalTrials.gov |
| NCT03895528 | LONAFARNIB | ClinicalTrials.gov | ||
| NCT03719690 | TIPIFARNIB | PHASE2 | 2024-06-21 | ClinicalTrials.gov |
1 to 10 of 110
See all 110 trialsNIH grants281
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FNTA papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 2 | 2025 |
| P50HD103538 | Intellectual and Developmental Disabilities Research Centers | 2 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 1 | 2025 |
| P01HL114501 | Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers | 1 | 2025 |
| P30AI060354 | Harvard University Center for AIDS Research | 1 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 1 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 1 | 2025 |
| P30CA016059 | Massey Cancer Center - Cancer Center Support Grant | 1 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 1 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 1 | 2025 |
1 to 10 of 281Source NIH's project files
See all 281 nih grantsPapers333
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Downregulation of prenylation machinery genes in peripheral blood of patients with Parkinson's disease: A pilot study. | IBRO Neurosci Rep | 2026 | 42775007 | PubTator, text mining | PubMed |
| High yield production of C-terminally processed KRAS4a, HRAS, and NRAS for biophysical study. | Protein Expr Purif | 2026 | 42142681 | PubTator, text mining | PubMed |
| CpG Methylation of Protein Prenyltransferase Genes FNTA, FNTB, PGGT1B and RABGGTA in Cancer Cell Lines. | Epigenomes | 2026 | 41892366 | PubTator, text mining | PubMed |
| Farnesyltransferase inhibitor LB42708 disables oncogenic RAS signaling and overcomes gefitinib resistance in NSCLC via FTase α-subunit and RAS degradation. | Cell Commun Signal | 2026 | 41821004 | PubTator, text mining | PubMed |
| IgRENE: integrating gene regulatory networks and drug ontologies towards selected modification of target gene's expression. | Brief Bioinform | 2025 | 41405964 | PubTator, text mining | PubMed |
| SCORCH2: A Generalized Heterogeneous Consensus Model for High-Enrichment Interaction-Based Virtual Screening. | Adv Sci (Weinh) | 2025 | 40832726 | PubTator, text mining | PubMed |
| The impact of sarcopenia on prognosis and fruquintinib efficacy in advanced colorectal cancer: a retrospective and mendelian randomization study. | Front Immunol | 2025 | 40740773 | PubTator, text mining | PubMed |
| Significant upregulation of prenyltransferase-related genes in neuromyelitis optica: Diagnostic potential and clinical correlations. | Mult Scler Relat Disord | 2025 | 40712510 | PubTator, text mining | PubMed |
| METTL3 Promotes Gastric Cancer Progression via Modulation of FNTA-Mediated KRAS/ERK Signaling Activation. | Mol Cancer Res | 2025 | 40353746 | PubTator, text mining | PubMed |
| Exploring the potential of compound-protein complex structure-free models in virtual screening using BlendNet. | Brief Bioinform | 2024 | 39804143 | PubTator, text mining | PubMed |
1 to 10 of 333
See all 333 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2339
GET https://conductscience.org/api/genes/v1/2339/patents?page=2