Gene · 2342
FNTB: farnesyltransferase, CAAX box, subunit beta
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FNTB: farnesyltransferase, CAAX box, subunit beta. Genes, record 2342. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2342
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49356 | Protein farnesyltransferase subunit beta | 437 | 14 | Ensembl, GeneID, HGNC |
Source UniProt
Patents13
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 45874 | P49356 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1186 | P49356 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1186 | P49356 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 30737 | P49356 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 133708 | P49356 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 4122 | P49356 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 922 | P49356 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 226309 | P49356 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 226309 | P49356 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 226309 | P49356 | Espacenet |
1 to 10 of 13
See all 13 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials110
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06775041 | LONAFARNIB | PHASE2 | ClinicalTrials.gov | |
| NCT06540963 | TIPIFARNIB | PHASE2 | ClinicalTrials.gov | |
| NCT05953545 | LONAFARNIB | PHASE2 | ClinicalTrials.gov | |
| NCT05693090 | TIPIFARNIB | PHASE1 | ClinicalTrials.gov | |
| NCT05229991 | LONAFARNIB | PHASE3 | ClinicalTrials.gov | |
| NCT04997902 | TIPIFARNIB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT04809233 | TIPIFARNIB | ClinicalTrials.gov | ||
| NCT04284774 | TIPIFARNIB | PHASE2 | 2025-06-03 | ClinicalTrials.gov |
| NCT03895528 | LONAFARNIB | ClinicalTrials.gov | ||
| NCT03719690 | TIPIFARNIB | PHASE2 | 2024-06-21 | ClinicalTrials.gov |
1 to 10 of 110
See all 110 trialsNIH grants220
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FNTB papers | Newest fiscal year |
|---|---|---|---|
| R01AI131703 | Regulation of T cell memory in tissue immunity | 2 | 2025 |
| R01AI140761 | Transcriptional and metabolic heterogeneity in T cell differentiation | 2 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 2 | 2025 |
| R37AI105887 | Metabolic checkpoint in dendritic cell subsets and adaptive immunity | 2 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 1 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 1 | 2025 |
| P30CA077598 | Cancer Center Support Grant | 1 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 1 | 2025 |
| P30ES019776 | HERCULES: Exposome Research Center | 1 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 1 | 2025 |
1 to 10 of 220Source NIH's project files
See all 220 nih grantsPapers191
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Downregulation of prenylation machinery genes in peripheral blood of patients with Parkinson's disease: A pilot study. | IBRO Neurosci Rep | 2026 | 42775007 | PubTator, text mining | PubMed |
| High yield production of C-terminally processed KRAS4a, HRAS, and NRAS for biophysical study. | Protein Expr Purif | 2026 | 42142681 | PubTator, text mining | PubMed |
| CpG Methylation of Protein Prenyltransferase Genes FNTA, FNTB, PGGT1B and RABGGTA in Cancer Cell Lines. | Epigenomes | 2026 | 41892366 | PubTator, text mining | PubMed |
| Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis. | Adv Sci (Weinh) | 2026 | 41747078 | PubTator, text mining | PubMed |
| Integrative computational approach to farnesyltransferase inhibition toward anti-liver cancer drug candidate from Syzygium cumini essential oils. | Mol Biol Res Commun | 2026 | 41346770 | PubTator, text mining | PubMed |
| Silencing of spindle apparatus coiled-coil protein 1 suppressed the progression of hepatocellular carcinoma through farnesyltransferase-beta and increased drug sensitivity. | Heliyon | 2024 | 39148981 | PubTator, text mining | PubMed |
| Drug repositioning and ovarian cancer, a study based on Mendelian randomisation analysis. | Front Oncol | 2024 | 38651149 | PubTator, text mining | PubMed |
| A Humanized Yeast System for Evaluating the Protein Prenylation of a Wide Range of Human and Viral CaaX Sequences. | bioRxiv | 2023 | 37786692 | PubTator, text mining | PubMed |
| The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19. | Int J Mol Sci | 2023 | 37686182 | PubTator, text mining | PubMed |
| HOXC8 mediates osteopontin expression in gastric cancer cells. | J Cancer | 2023 | 37670969 | PubTator, text mining | PubMed |
1 to 10 of 191
See all 191 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2342
GET https://conductscience.org/api/genes/v1/2342/patents