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Gene · 2342

FNTB: farnesyltransferase, CAAX box, subunit beta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FNTB: farnesyltransferase, CAAX box, subunit beta. Genes, record 2342. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2342

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Gene

Symbol
FNTB
HGNC
Name
farnesyltransferase, CAAX box, subunit beta
HGNC
NCBI Gene ID
2342
NCBI Gene
HGNC ID
HGNC:3785
HGNC
Ensembl
ENSG00000257365
NCBI Gene
Aliases
FPTB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49356Protein farnesyltransferase subunit beta43714Ensembl, GeneID, HGNC

Source UniProt

Patents13

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445874P49356Espacenet
EP 4650780 A22025-11-191186P49356Espacenet
JP 2025517970 A2025-06-121186P49356Espacenet
US 11446398 B22022-09-2030737P49356Espacenet
JP 2022524081 A2022-04-27133708P49356Espacenet
US 11078247 B22021-08-034122P49356Espacenet
WO 2020043864 A12020-03-05922P49356Espacenet
JP 2019054813 A2019-04-11226309P49356Espacenet
JP 2017121241 A2017-07-13226309P49356Espacenet
JP 2015516143 A2015-06-08226309P49356Espacenet

1 to 10 of 13

See all 13 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LONAFARNIBCHEMBL298734Protein farnesyltransferase inhibitorINHIBITORChEMBL
TIPIFARNIBCHEMBL289228Protein farnesyltransferase inhibitorINHIBITORChEMBL

Trials110

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06775041LONAFARNIBPHASE2ClinicalTrials.gov
NCT06540963TIPIFARNIBPHASE2ClinicalTrials.gov
NCT05953545LONAFARNIBPHASE2ClinicalTrials.gov
NCT05693090TIPIFARNIBPHASE1ClinicalTrials.gov
NCT05229991LONAFARNIBPHASE3ClinicalTrials.gov
NCT04997902TIPIFARNIBPHASE1/PHASE2ClinicalTrials.gov
NCT04809233TIPIFARNIBClinicalTrials.gov
NCT04284774TIPIFARNIBPHASE22025-06-03ClinicalTrials.gov
NCT03895528LONAFARNIBClinicalTrials.gov
NCT03719690TIPIFARNIBPHASE22024-06-21ClinicalTrials.gov

1 to 10 of 110

See all 110 trials

NIH grants220

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFNTB papersNewest fiscal year
R01AI131703Regulation of T cell memory in tissue immunity22025
R01AI140761Transcriptional and metabolic heterogeneity in T cell differentiation22025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal22025
R37AI105887Metabolic checkpoint in dendritic cell subsets and adaptive immunity22025
P30CA015704Cancer Center Support Grant12025
P30CA016086Cancer Center Support Grant12025
P30CA077598Cancer Center Support Grant12025
P30DK063491Diabetes Research Center (DRC)12025
P30ES019776HERCULES: Exposome Research Center12025
P40OD010440Caenorhabditis Genetics Center12025

1 to 10 of 220Source NIH's project files

See all 220 nih grants

Papers191

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Downregulation of prenylation machinery genes in peripheral blood of patients with Parkinson's disease: A pilot study.IBRO Neurosci Rep202642775007PubTator, text miningPubMed
High yield production of C-terminally processed KRAS4a, HRAS, and NRAS for biophysical study.Protein Expr Purif202642142681PubTator, text miningPubMed
CpG Methylation of Protein Prenyltransferase Genes FNTA, FNTB, PGGT1B and RABGGTA in Cancer Cell Lines.Epigenomes202641892366PubTator, text miningPubMed
Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis.Adv Sci (Weinh)202641747078PubTator, text miningPubMed
Integrative computational approach to farnesyltransferase inhibition toward anti-liver cancer drug candidate from Syzygium cumini essential oils.Mol Biol Res Commun202641346770PubTator, text miningPubMed
Silencing of spindle apparatus coiled-coil protein 1 suppressed the progression of hepatocellular carcinoma through farnesyltransferase-beta and increased drug sensitivity.Heliyon202439148981PubTator, text miningPubMed
Drug repositioning and ovarian cancer, a study based on Mendelian randomisation analysis.Front Oncol202438651149PubTator, text miningPubMed
A Humanized Yeast System for Evaluating the Protein Prenylation of a Wide Range of Human and Viral CaaX Sequences.bioRxiv202337786692PubTator, text miningPubMed
The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19.Int J Mol Sci202337686182PubTator, text miningPubMed
HOXC8 mediates osteopontin expression in gastric cancer cells.J Cancer202337670969PubTator, text miningPubMed

1 to 10 of 191

See all 191 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2342

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