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Gene · 25939

SAMHD1: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SAMHD1: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. Genes, record 25939. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/25939

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Gene

Symbol
SAMHD1
HGNC
Name
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
HGNC
NCBI Gene ID
25939
NCBI Gene
HGNC ID
HGNC:15925
HGNC
Ensembl
ENSG00000101347
NCBI Gene
Aliases
AGS5, CHBL2, DCIP, HDDC1, MOP-5, Mg11, SBBI88, hSAMHD1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y3Z3Deoxynucleoside triphosphate triphosphohydrolase SAMHD162676Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4824261 A22026-10-21130Q9Y3Z3Espacenet
JP 2026115409 A2026-07-093Q9Y3Z3Espacenet
EP 4704859 A12026-03-113Q9Y3Z3Espacenet
JP 2026004568 A2026-01-1462609Q9Y3Z3Espacenet
EP 4650780 A22025-11-1919348Q9Y3Z3Espacenet
EP 4641201 A22025-10-2924586Q9Y3Z3Espacenet
JP 2025517969 A2025-06-1224586Q9Y3Z3Espacenet
JP 2025517970 A2025-06-1219348Q9Y3Z3Espacenet
JP 2024504002 A2024-01-3059Q9Y3Z3Espacenet
JP 2024502755 A2024-01-2358Q9Y3Z3Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,175

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSAMHD1 papersNewest fiscal year
R01AI136581Lentivirus Replication Strategy and Pathogenesis322025
P30AI027763UCSF-Bay Area Center for AIDS Research222025
P30AI036219Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)152025
P30CA016058Cancer Center Support Grant142025
R01AI162633SAMHD1 mediated dNTP regulation and HIV in myeloid cells132025
P30AI050409Center for AIDS Research at Emory University112025
ZIAAI001220Pathogenesis, and Outcome of Autoinflammatory Diseases, NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still's-like Diseases, and other Undifferentiated Autoinflammatory Diseases112025
P30AI060354Harvard University Center for AIDS Research102025
P30AI117970District of Columbia Center for AIDS Research102025
P30AI036214San Diego Center for AIDS Research (SD CFAR)82025

1 to 10 of 2,175Source NIH's project files

See all 2,175 nih grants

Papers2,857

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Modeling calcific aortic valve disease with engineered human valve tissues identifies SAMHD1 as a therapeutic target.Biomaterials202742501740PubTator, text miningPubMed
Nucleotide metabolic reprogramming: a "double-edged sword" in obesity-related inflammation-from metabolic adaptation to pathological imbalance.J Physiol Biochem202642799975PubTator, text miningPubMed
The interaction between HIV-1 central polypurine tract and host SAMHD1 dNTPase during HIV-1 vector transduction in human primary nondividing monocyte-derived macrophages.Virus Genes202642722809PubTator, text miningPubMed
Single-cell and spatial transcriptomics define eosinophil heterogeneity during influenza A virus-induced exacerbation of fungal allergic asthma in C57BL/6 mice.J Leukoc Biol202642707006PubTator, text miningPubMed
Iterative genetic testing identifies SAMHD1 deficiency caused by a homozygous balanced translocation.J Hum Immun202642657394PubTator, text miningPubMed
p21 (CDKN1A) Is the Major Driver of Sulforaphane-Mediated Reduction in SAMHD1 T592 Phosphorylation in Macrophages.Biomolecules202642650879PubTator, text miningPubMed
SAMHD1 enhances HIV-1-induced glycolysis in monocytic cells through hexokinase 2 upregulation.bioRxiv202642619998PubTator, text miningPubMed
Type I Interferonopathies in the Differential Diagnosis of Vasculitis: A Comprehensive Review.J Vis Exp202642611810PubTator, text miningPubMed
Transition Metal Activation Reframes SAMHD1 Regulation.ACS Chem Biol202642457644PubTator, text miningPubMed
TLR3 activation of microglia-containing cerebral organoid induces antiviral factors against HIV-1 infection.Front Pharmacol202642453569PubTator, text miningPubMed

1 to 10 of 2,857

See all 2,857 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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