Gene · 25939
SAMHD1: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SAMHD1: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. Genes, record 25939. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/25939
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9Y3Z3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 626 | 76 | Ensembl, GeneID, HGNC |
Source UniProt
Patents40
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4824261 A2 | 2026-10-21 | 130 | Q9Y3Z3 | Espacenet |
| JP 2026115409 A | 2026-07-09 | 3 | Q9Y3Z3 | Espacenet |
| EP 4704859 A1 | 2026-03-11 | 3 | Q9Y3Z3 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 62609 | Q9Y3Z3 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 19348 | Q9Y3Z3 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 24586 | Q9Y3Z3 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 24586 | Q9Y3Z3 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 19348 | Q9Y3Z3 | Espacenet |
| JP 2024504002 A | 2024-01-30 | 59 | Q9Y3Z3 | Espacenet |
| JP 2024502755 A | 2024-01-23 | 58 | Q9Y3Z3 | Espacenet |
1 to 10 of 40
See all 40 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,175
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SAMHD1 papers | Newest fiscal year |
|---|---|---|---|
| R01AI136581 | Lentivirus Replication Strategy and Pathogenesis | 32 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 22 | 2025 |
| P30AI036219 | Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR) | 15 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 14 | 2025 |
| R01AI162633 | SAMHD1 mediated dNTP regulation and HIV in myeloid cells | 13 | 2025 |
| P30AI050409 | Center for AIDS Research at Emory University | 11 | 2025 |
| ZIAAI001220 | Pathogenesis, and Outcome of Autoinflammatory Diseases, NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still's-like Diseases, and other Undifferentiated Autoinflammatory Diseases | 11 | 2025 |
| P30AI060354 | Harvard University Center for AIDS Research | 10 | 2025 |
| P30AI117970 | District of Columbia Center for AIDS Research | 10 | 2025 |
| P30AI036214 | San Diego Center for AIDS Research (SD CFAR) | 8 | 2025 |
1 to 10 of 2,175Source NIH's project files
See all 2,175 nih grantsPapers2,857
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Modeling calcific aortic valve disease with engineered human valve tissues identifies SAMHD1 as a therapeutic target. | Biomaterials | 2027 | 42501740 | PubTator, text mining | PubMed |
| Nucleotide metabolic reprogramming: a "double-edged sword" in obesity-related inflammation-from metabolic adaptation to pathological imbalance. | J Physiol Biochem | 2026 | 42799975 | PubTator, text mining | PubMed |
| The interaction between HIV-1 central polypurine tract and host SAMHD1 dNTPase during HIV-1 vector transduction in human primary nondividing monocyte-derived macrophages. | Virus Genes | 2026 | 42722809 | PubTator, text mining | PubMed |
| Single-cell and spatial transcriptomics define eosinophil heterogeneity during influenza A virus-induced exacerbation of fungal allergic asthma in C57BL/6 mice. | J Leukoc Biol | 2026 | 42707006 | PubTator, text mining | PubMed |
| Iterative genetic testing identifies SAMHD1 deficiency caused by a homozygous balanced translocation. | J Hum Immun | 2026 | 42657394 | PubTator, text mining | PubMed |
| p21 (CDKN1A) Is the Major Driver of Sulforaphane-Mediated Reduction in SAMHD1 T592 Phosphorylation in Macrophages. | Biomolecules | 2026 | 42650879 | PubTator, text mining | PubMed |
| SAMHD1 enhances HIV-1-induced glycolysis in monocytic cells through hexokinase 2 upregulation. | bioRxiv | 2026 | 42619998 | PubTator, text mining | PubMed |
| Type I Interferonopathies in the Differential Diagnosis of Vasculitis: A Comprehensive Review. | J Vis Exp | 2026 | 42611810 | PubTator, text mining | PubMed |
| Transition Metal Activation Reframes SAMHD1 Regulation. | ACS Chem Biol | 2026 | 42457644 | PubTator, text mining | PubMed |
| TLR3 activation of microglia-containing cerebral organoid induces antiviral factors against HIV-1 infection. | Front Pharmacol | 2026 | 42453569 | PubTator, text mining | PubMed |
1 to 10 of 2,857
See all 2,857 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/25939
GET https://conductscience.org/api/genes/v1/25939/patents?page=2