ConductScience.org, home

Gene · 2642

GCGR: glucagon receptor

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. GCGR: glucagon receptor. Genes, record 2642. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2642

On this page

Gene

Symbol
GCGR
HGNC
Name
glucagon receptor
HGNC
NCBI Gene ID
2642
NCBI Gene
HGNC ID
HGNC:4192
HGNC
Ensembl
ENSG00000215644
NCBI Gene
Aliases
GGR, GL-R, MVAH
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P47871Glucagon receptor47727Ensembl, GeneID, HGNC

Source UniProt

Patents113

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4777830 A12026-07-2216P47871Espacenet
JP 2026004568 A2026-01-1447605P47871Espacenet
EP 4650780 A22025-11-1911728P47871Espacenet
JP 2025147176 A2025-10-065832P47871Espacenet
JP 2025529142 A2025-09-041682P47871Espacenet
JP 2025529142 A2025-09-046467P47871Espacenet
US 12371689 B22025-07-291682P47871Espacenet
US 12371689 B22025-07-296467P47871Espacenet
JP 2025517970 A2025-06-1211728P47871Espacenet
US 12269889 B22025-04-08153P47871Espacenet

1 to 10 of 113

See all 113 patents

Drugs15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ADOMEGLIVANTCHEMBL3707351Glucagon receptor antagonistANTAGONISTChEMBL
COTADUTIDECHEMBL4297630Glucagon receptor agonistAGONISTChEMBL
CROTEDUMABCHEMBL3707278Glucagon receptor inhibitorINHIBITORChEMBL
DASIGLUCAGONCHEMBL4297741Glucagon receptor agonistAGONISTChEMBL
DASIGLUCAGON HYDROCHLORIDECHEMBL4650274Glucagon receptor agonistAGONISTChEMBL
EFINOPEGDUTIDECHEMBL4297576Glucagon receptor agonistAGONISTChEMBL
GLUCAGONCHEMBL5314341Glucagon receptor agonistAGONISTChEMBL
GLUCAGON HYDROCHLORIDECHEMBL5314342Glucagon receptor agonistAGONISTChEMBL
MK-0893CHEMBL1933349Glucagon receptor antagonistANTAGONISTChEMBL
MK-3577CHEMBL1933350Glucagon receptor antagonistANTAGONISTChEMBL

1 to 10 of 15

See all 15 drugs

Trials173

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07467447RETATRUTIDEPHASE2ClinicalTrials.gov
NCT07357415RETATRUTIDEPHASE3ClinicalTrials.gov
NCT07232719RETATRUTIDEPHASE3ClinicalTrials.gov
NCT07212868VOLAGIDEMABPHASE1ClinicalTrials.gov
NCT07206290SURVODUTIDEPHASE2ClinicalTrials.gov
NCT06982859RETATRUTIDEPHASE1ClinicalTrials.gov
NCT06982846RETATRUTIDEPHASE1ClinicalTrials.gov
NCT06859268RETATRUTIDEPHASE3ClinicalTrials.gov
NCT06854861GLUCAGONPHASE1/PHASE2ClinicalTrials.gov
NCT06745284SURVODUTIDEPHASE1ClinicalTrials.gov

1 to 10 of 173

See all 173 trials

NIH grants907

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGCGR papersNewest fiscal year
P30DK020593Vanderbilt Diabetes Research Center182025
P30DK058404Molecular and Cellular Basis for Digestive Diseases72025
R35GM130307Development and Applications of Bioorthogonal Chemistry72025
P30DK017047Diabetes Research Center62025
I01BX000666Islet alterations in type 2 diabetes52025
P30DK036836Diabetes Research Center52025
P30DK056336UAB Nutrition Obesity Research Center (NORC)52025
P30DK056341Washington University Nutrition Obesity Research Center52025
T32DK007563Multidisciplinary Training in Molecular Endocrinology52025
P30DK020572Michigan Diabetes Research Center (MDRC)42025

1 to 10 of 907Source NIH's project files

See all 907 nih grants

Papers2,157

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Survodutide for the treatment of obesity: Mechanistic rationale, clinical evidence, and remaining uncertainties.Contemp Clin Trials202642822760PubTator, text miningPubMed
Survodutide Once Weekly in Adults with Obesity and Type 2 Diabetes.N Engl J Med202642820639PubTator, text miningPubMed
Efficacy and Safety of Dual GLP-1/Glucagon Receptor Agonism in Overweight and Obesity: A Class-Specific Systematic Review and Meta-Analysis.Diabetes Obes Metab202642811393PubTator, text miningPubMed
Metabolic control by liver-kidney crosstalk and glucagon in health and disease.Nat Rev Nephrol202642811087PubTator, text miningPubMed
GLP-1 receptor agonists and podocyte senescence in diabetic kidney disease: structural pharmacology, mechanistic evidence, and multi-receptor agonism.Biochem Pharmacol202642777788PubTator, text miningPubMed
[New Therapeutic Approaches for MASH: Mechanisms and Clinical Promise].Z Gastroenterol202642777699PubTator, text miningPubMed
Approach to the patient with primary hyperglucagonemia.J Clin Endocrinol Metab202642766419PubTator, text miningPubMed
Detection and Excretion Profile of Retatrutide in Human Plasma and Urine by LC-HRMS: Implications for Antidoping Analysis.Rapid Commun Mass Spectrom202642745421PubTator, text miningPubMed
Structural basis for small-molecule agonism at GCGR and GIPR via a conserved intracellular allosteric site.Acta Pharmacol Sin202642736455PubTator, text miningPubMed
Cardiovascular effects of incretin receptor agonists: beyond glycemic control.Can J Physiol Pharmacol202642721492PubTator, text miningPubMed

1 to 10 of 2,157

See all 2,157 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2642

GET https://conductscience.org/api/genes/v1/2642/patents?page=2