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Gene · 2643

GCH1: GTP cyclohydrolase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GCH1: GTP cyclohydrolase 1. Genes, record 2643. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2643

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Gene

Symbol
GCH1
HGNC
Name
GTP cyclohydrolase 1
HGNC
NCBI Gene ID
2643
NCBI Gene
HGNC ID
HGNC:4193
HGNC
Ensembl
ENSG00000131979
NCBI Gene
Aliases
DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30793GTP cyclohydrolase 125011Ensembl, GeneID, HGNC

Source UniProt

Patents134

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026193218 A12026-09-17372P30793Espacenet
EP 4729620 A12026-04-229P30793Espacenet
JP 2026067851 A2026-04-21306P30793Espacenet
US 12570963 B22026-03-1045P30793Espacenet
US 12516298 B22026-01-0645P30793Espacenet
JP 2025169942 A2025-11-141033P30793Espacenet
JP 2025169942 A2025-11-141035P30793Espacenet
EP 4623087 A22025-10-0199P30793Espacenet
JP 2025118760 A2025-08-132P30793Espacenet
JP 2025062601 A2025-04-1450P30793Espacenet

1 to 10 of 134

See all 134 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,421

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGCH1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
P30AG028740University of Florida Older Americans Independence Center (OAIC)62025
P30CA008748Cancer Center Support Grant62025
R01HL060190Metabolic reprogramming of smooth muscle cells in pulmonary hypertension52025
R35NS105076Unravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain52025
P30CA068485Cancer Center Support Grant42025
R01AI048071Mapping Drug Resistance Genes in Plasmodium falciparum42025
R37AI050234Defining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug Resistance42025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)42025
R01AI109023Defining P. falciparum resistance to artemisinin-based combination therapies32025

1 to 10 of 1,421Source NIH's project files

See all 1,421 nih grants

Papers2,670

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated network toxicology, machine learning, and multi-omics characterization of 2,4-DTBP neurotoxicity.Chem Biol Interact202642822756PubTator, text miningPubMed
Longxue tongluo capsule enhances ischemic stroke recovery via microbiota-metabolite-gene interactions.Metab Brain Dis202642804018PubTator, text miningPubMed
Predicted deficiency of the GTP cyclohydrolase I feedback regulatory protein (GFRP): a disorder of dynamic tetrahydrobiopterin homeostasis.Mol Genet Metab202642800280PubTator, text miningPubMed
Pharmacological targeting of ferroptosis in cancer: mechanisms, tumor immunity, and translational challenges.Pharmacol Rep202642789241PubTator, text miningPubMed
FTO/m6A Regulate Prenatal Nicotine-Induced eNOS Uncoupling and BP Susceptibility.Hypertension202642779519PubTator, text miningPubMed
Correction to: Metabolic adaptations of inflammatory macrophages govern ferroptosis susceptibility via the GCH1-BH4-iNOS axis.J Immunol202642763889PubTator, text miningPubMed
Arginine metabolism, polyamine homeostasis and ferroptosis in cancer: Molecular links and therapeutic opportunities (Review).Mol Med Rep202642757463PubTator, text miningPubMed
GCH1, identified by a ferroptosis-related prognostic model, contributes to progression and drug resistance of esophageal cancer.Chin J Cancer Res202642713103PubTator, text miningPubMed
The redox paradox in neurological disorders: balancing cytoprotection, ferroptosis, and therapeutic targeting.Brain Res202642700879PubTator, text miningPubMed
Association between circulating GTP cyclohydrolase 1 concentrations and acute ischemic stroke: an exploratory case-control study in a Chinese population.Front Neurol202642682434PubTator, text miningPubMed

1 to 10 of 2,670

See all 2,670 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2643

GET https://conductscience.org/api/genes/v1/2643/patents?page=2