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Gene · 2648

KAT2A: lysine acetyltransferase 2A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KAT2A: lysine acetyltransferase 2A. Genes, record 2648. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2648

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Gene

Symbol
KAT2A
HGNC
Name
lysine acetyltransferase 2A
HGNC
NCBI Gene ID
2648
NCBI Gene
HGNC ID
HGNC:4201
HGNC
Ensembl
ENSG00000108773
NCBI Gene
Aliases
GCN5, GCN5L2, PCAF-b, hGCN5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92830Histone acetyltransferase KAT2A83714Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450515Q92830Espacenet
EP 4650780 A22025-11-19649Q92830Espacenet
EP 4641201 A22025-10-29450Q92830Espacenet
JP 2025517969 A2025-06-12450Q92830Espacenet
JP 2025517970 A2025-06-12649Q92830Espacenet
US 11446398 B22022-09-2042398Q92830Espacenet
JP 2022524081 A2022-04-27145369Q92830Espacenet
US 11078247 B22021-08-035693Q92830Espacenet
US 11034647 B22021-06-155Q92830Espacenet
KR 1020210060362 A2021-05-261Q92830Espacenet

1 to 10 of 27

See all 27 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,312

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKAT2A papersNewest fiscal year
P30CA016672Cancer Center Support Grant342025
P30CA010815Consolidated Basic Cancer Research Program182025
ZIABC011488Targeting Cancer Through Modifications and Metabolism142025
P30CA008748Cancer Center Support Grant132025
P30AI027763UCSF-Bay Area Center for AIDS Research102025
P30ES013508Center of Excellence in Environmental Toxicology72025
R35GM118068Transcription regulation in chromatin72025
P30CA076292Moffitt Cancer Center Support Grant62025
R35GM118090Molecular Mechanisms, Pathways and Inhibition of Acetyl-Transfer Reactions62025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025

1 to 10 of 2,312Source NIH's project files

See all 2,312 nih grants

Papers3,420

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cancer Stem Cell Quiescence: Molecular and Microenvironmental Evidence for an Actively Regulated Adaptive Survival Strategy.Cancer Med202642768738PubTator, text miningPubMed
Structure-guided identification and experimental validation of NAT10-targeting small molecules in colorectal cancer cells.J Comput Aided Mol Des202642742862PubTator, text miningPubMed
MMSDH facilitates ACSL4 propionylation to counteract ferroptosis upon hypoxia and impairs PDAC chemotherapy efficacy.Nat Cancer202642728394PubTator, text miningPubMed
DHA Targets RAB1B to Mediate the Driving Force Transmission of Copper Ion Vesicular Endocytosis Under Copper Overload for Promoting Cuproptosis and Ferroptosis in Hepatic Stellate Cells.Int J Biol Sci202642694667PubTator, text miningPubMed
Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.J Precis Med (Amst)202642644057PubTator, text miningPubMed
Structural plasticity drives convergent evolution and functional diversification of GNAT polyamine acetyltransferases.Structure202642636798PubTator, text miningPubMed
Pharmacological targeting of GCN5/PCAF (KAT2A/B): current drug discovery strategies and translational potential.Drug Discov Today202642624285PubTator, text miningPubMed
The KAT2/HDACⅡa-PGK-ALDO axis constitutes a dual degradation inhibition cascade links energy stress to glycolytic amplification.Proc Natl Acad Sci U S A202642611992PubTator, text miningPubMed
Top-Down Sequencing of Intact Proteoforms Using the timsOmni Mass Spectrometer: Accurate Determination of Co-Occurring Histone Modifications.Mol Cell Proteomics202642607871PubTator, text miningPubMed
The GCN5L2-SIX1 complex drives glycolysis to promote progression of triple-negative breast cancer.Cancer Lett202642601012PubTator, text miningPubMed

1 to 10 of 3,420

See all 3,420 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2648

GET https://conductscience.org/api/genes/v1/2648/patents?page=2