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Gene · 2672

GFI1: growth factor independent 1 transcriptional repressor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GFI1: growth factor independent 1 transcriptional repressor. Genes, record 2672. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2672

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Gene

Symbol
GFI1
HGNC
Name
growth factor independent 1 transcriptional repressor
HGNC
NCBI Gene ID
2672
NCBI Gene
HGNC ID
HGNC:4237
HGNC
Ensembl
ENSG00000162676
NCBI Gene
Aliases
GFI-1, GFI1A, SCN2, ZNF163
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99684Zinc finger protein Gfi-14220Ensembl, GeneID, HGNC

Source UniProt

Patents51

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4698657 A22026-02-25380Q99684Espacenet
JP 2026004568 A2026-01-1448326Q99684Espacenet
JP 2026004568 A2026-01-1448327Q99684Espacenet
JP 2026004568 A2026-01-1448328Q99684Espacenet
WO 2025248252 A12025-12-046Q99684Espacenet
EP 4641201 A22025-10-293159Q99684Espacenet
JP 2025147176 A2025-10-0615041Q99684Espacenet
JP 2025517969 A2025-06-123159Q99684Espacenet
JP 2025028160 A2025-02-2815041Q99684Espacenet
KR 1020250010750 A2025-01-2115041Q99684Espacenet

1 to 10 of 51

See all 51 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,746

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGFI1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant122025
R01CA159859Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma122025
P30CA016672Cancer Center Support Grant112025
P30CA021765Cancer Center Support Grant (CCSG)92025
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN82025
P30CA030199Cancer Center Support Grant (CCSG)82025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant82025
R01DC014832Enhancing Atoh1 function in hair cell regeneration82025
P30ES009089Center for Environmental Health in Northern Manhattan62025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025

1 to 10 of 1,746Source NIH's project files

See all 1,746 nih grants

Papers1,987

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Agonism of GPR84 Attenuates Free Fatty Acid-Induced Endothelial Inflammation and Monocyte Adhesion via Gfi1/NF-κB Pathway.Arq Bras Cardiol202642820599PubTator, text miningPubMed
Gambogic Acid Induces Apoptosis in Raji Lymphoma Cells Via Gfi-1/STAT5 Signaling.J Vis Exp202642644555PubTator, text miningPubMed
Macrophage-specific targeting of histone demethylases with small-molecule inhibitors suppresses inflammatory response in vivo.J Biol Chem202642409265PubTator, text miningPubMed
GFI1 enhances MHC-I expression in tumor cells and augments tumor responsiveness to PD-1/PD-L1 inhibitors.Cancer Immunol Immunother202642174278PubTator, text miningPubMed
The GFI1 Gene Family: Evolution, Structure, and Its Role in Immune Responses.J Mol Evol202642045596PubTator, text miningPubMed
The GFI1-FOXO1 axis regulates NK cell maturation and function.Nat Commun202642020400PubTator, text miningPubMed
Base-resolution DNA methylome of human MDS hematopoietic stem cell reveals TET2-GFI1 epigenetic axis repressing MDS.Immun Inflamm202641929356PubTator, text miningPubMed
Lineage-Specific Disruption of Hematopoiesis by Oxaliplatin: Mechanisms of Erythropoietin Resistance and Immune Suppression.J Hematol Oncol Res202641868970PubTator, text miningPubMed
Transcriptional programming governs the transition from shared progenitors to divergent CD8+ T cell fates.Immunol Cell Biol202641814649PubTator, text miningPubMed
An interpretable machine learning model for predicting prognosis of medulloblastoma integrating genetic and clinical features.Commun Med (Lond)202641807642PubTator, text miningPubMed

1 to 10 of 1,987

See all 1,987 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2672

GET https://conductscience.org/api/genes/v1/2672/patents?page=2