Gene · 2672
GFI1: growth factor independent 1 transcriptional repressor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GFI1: growth factor independent 1 transcriptional repressor. Genes, record 2672. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2672
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99684 | Zinc finger protein Gfi-1 | 422 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents51
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4698657 A2 | 2026-02-25 | 380 | Q99684 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 48326 | Q99684 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 48327 | Q99684 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 48328 | Q99684 | Espacenet |
| WO 2025248252 A1 | 2025-12-04 | 6 | Q99684 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3159 | Q99684 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15041 | Q99684 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3159 | Q99684 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15041 | Q99684 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15041 | Q99684 | Espacenet |
1 to 10 of 51
See all 51 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,746
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GFI1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| R01CA159859 | Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma | 12 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 9 | 2025 |
| P01CA096832 | NORMAL & NEOPLASTIC GROWTH IN THE BRAIN | 8 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 8 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 8 | 2025 |
| R01DC014832 | Enhancing Atoh1 function in hair cell regeneration | 8 | 2025 |
| P30ES009089 | Center for Environmental Health in Northern Manhattan | 6 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 5 | 2025 |
1 to 10 of 1,746Source NIH's project files
See all 1,746 nih grantsPapers1,987
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Agonism of GPR84 Attenuates Free Fatty Acid-Induced Endothelial Inflammation and Monocyte Adhesion via Gfi1/NF-κB Pathway. | Arq Bras Cardiol | 2026 | 42820599 | PubTator, text mining | PubMed |
| Gambogic Acid Induces Apoptosis in Raji Lymphoma Cells Via Gfi-1/STAT5 Signaling. | J Vis Exp | 2026 | 42644555 | PubTator, text mining | PubMed |
| Macrophage-specific targeting of histone demethylases with small-molecule inhibitors suppresses inflammatory response in vivo. | J Biol Chem | 2026 | 42409265 | PubTator, text mining | PubMed |
| GFI1 enhances MHC-I expression in tumor cells and augments tumor responsiveness to PD-1/PD-L1 inhibitors. | Cancer Immunol Immunother | 2026 | 42174278 | PubTator, text mining | PubMed |
| The GFI1 Gene Family: Evolution, Structure, and Its Role in Immune Responses. | J Mol Evol | 2026 | 42045596 | PubTator, text mining | PubMed |
| The GFI1-FOXO1 axis regulates NK cell maturation and function. | Nat Commun | 2026 | 42020400 | PubTator, text mining | PubMed |
| Base-resolution DNA methylome of human MDS hematopoietic stem cell reveals TET2-GFI1 epigenetic axis repressing MDS. | Immun Inflamm | 2026 | 41929356 | PubTator, text mining | PubMed |
| Lineage-Specific Disruption of Hematopoiesis by Oxaliplatin: Mechanisms of Erythropoietin Resistance and Immune Suppression. | J Hematol Oncol Res | 2026 | 41868970 | PubTator, text mining | PubMed |
| Transcriptional programming governs the transition from shared progenitors to divergent CD8+ T cell fates. | Immunol Cell Biol | 2026 | 41814649 | PubTator, text mining | PubMed |
| An interpretable machine learning model for predicting prognosis of medulloblastoma integrating genetic and clinical features. | Commun Med (Lond) | 2026 | 41807642 | PubTator, text mining | PubMed |
1 to 10 of 1,987
See all 1,987 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2672
GET https://conductscience.org/api/genes/v1/2672/patents?page=2