Gene · 27115
PDE7B: phosphodiesterase 7B
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PDE7B: phosphodiesterase 7B. Genes, record 27115. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27115
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NP56 | 3',5'-cyclic-AMP phosphodiesterase 7B | 450 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents66
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2025245188 A2 | 2025-11-27 | 12 | Q9NP56 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4270 | Q9NP56 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4270 | Q9NP56 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 33183 | Q9NP56 | Espacenet |
| JP 2025004127 A | 2025-01-14 | 17 | Q9NP56 | Espacenet |
| KR 1020250007057 A | 2025-01-13 | 6 | Q9NP56 | Espacenet |
| JP 2024170507 A | 2024-12-10 | 6 | Q9NP56 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 33183 | Q9NP56 | Espacenet |
| EP 4374872 A1 | 2024-05-29 | 108 | Q9NP56 | Espacenet |
| JP 2024015430 A | 2024-02-01 | 6 | Q9NP56 | Espacenet |
1 to 10 of 66
See all 66 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| DIPYRIDAMOLE | CHEMBL932 | 3',5'-cyclic phosphodiesterase inhibitor | INHIBITOR | ChEMBL |
| FLAVOXATE | CHEMBL1493 | Phosphodiesterase 7 inhibitor | INHIBITOR | ChEMBL |
| FLAVOXATE HYDROCHLORIDE | CHEMBL1200875 | Phosphodiesterase 7 inhibitor | INHIBITOR | ChEMBL |
| PENTOXIFYLLINE | CHEMBL628 | 3',5'-cyclic phosphodiesterase inhibitor | INHIBITOR | ChEMBL |
Trials135
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07349472 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT07315139 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07252518 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07199504 | DIPYRIDAMOLE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07088328 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT07086794 | PENTOXIFYLLINE | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07085806 | PENTOXIFYLLINE | ClinicalTrials.gov | ||
| NCT06998628 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT06986031 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov | |
| NCT06912763 | PENTOXIFYLLINE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 135
See all 135 trialsNIH grants401
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PDE7B papers | Newest fiscal year |
|---|---|---|---|
| U24AG021886 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) | 3 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 2 | 2025 |
| P30EY014104 | P30 Core Grant for Vision Research | 2 | 2025 |
| R01EY022305 | NEIGHBORHOOD Consortium for POAG Genetics | 2 | 2025 |
| R01MH126929 | Latrophilin Function in Synapse Formation | 2 | 2025 |
| ZIADE000380 | The role of stem cells in skeletal health and disease | 2 | 2025 |
| P01AG078106 | Neuroimmunology of AD and CAA with focus on innate immunity and lymphatics | 1 | 2025 |
| P20GM103418 | Kansas IDeA Network of Biomedical Research Excellence 5 | 1 | 2025 |
| P30AG021332 | Wake Forest Claude D. Pepper OAIC - Renewal | 1 | 2025 |
| P30AG072973 | University of Kansas Alzheimer's Disease Research Center (KU ADRC) | 1 | 2025 |
1 to 10 of 401Source NIH's project files
See all 401 nih grantsPapers379
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Astrocytic PDE7B Drives Blood-Brain Barrier Breakdown via Extracellular Vesicles in Demyelinating Disease. | Glia | 2026 | 42708970 | PubTator, text mining | PubMed |
| A compact five-gene immuno-fibrotic profile distinguishing systemic sclerosis subtypes with PXDN validated as a fibrosis-associated target. | Front Immunol | 2026 | 42688363 | PubTator, text mining | PubMed |
| Integrative analysis of single nucleotide polymorphism of PDE7B (rs2327669) with biopsychosocial and biochemical parameters in β-thalassemia major patients in Pakistani Cohort. | Mol Biol Rep | 2026 | 42313217 | PubTator, text mining | PubMed |
| Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells. | Nat Immunol | 2026 | 42230957 | PubTator, text mining | PubMed |
| Epigenetic regulation in a high-sugar environment (Review). | Int J Mol Med | 2026 | 41860052 | PubTator, text mining | PubMed |
| Epigenomic subtypes of late-onset Alzheimer's disease reveal distinct microglial signatures. | Acta Neuropathol | 2026 | 41733741 | PubTator, text mining | PubMed |
| Role and underlying mechanisms of miR‑200 family in breast cancer (Review). | Int J Oncol | 2026 | 41716019 | PubTator, text mining | PubMed |
| RETRACTION: Role and Mechanism of Circ-PDE7B in the Formation of Keloid. | Int Wound J | 2025 | 40769516 | PubTator, text mining | PubMed |
| Downregulation of CMIP contributes to preeclampsia development by impairing trophoblast function via the PDE7B-cAMP pathway. | Cell Mol Life Sci | 2025 | 40372501 | PubTator, text mining | PubMed |
| Chemical Space Exploration and Machine Learning-Based Screening of PDE7A Inhibitors. | Pharmaceuticals (Basel) | 2025 | 40283882 | PubTator, text mining | PubMed |
1 to 10 of 379
See all 379 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/27115
GET https://conductscience.org/api/genes/v1/27115/patents?page=2