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Gene · 27115

PDE7B: phosphodiesterase 7B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PDE7B: phosphodiesterase 7B. Genes, record 27115. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27115

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Gene

Symbol
PDE7B
HGNC
Name
phosphodiesterase 7B
HGNC
NCBI Gene ID
27115
NCBI Gene
HGNC ID
HGNC:8792
HGNC
Ensembl
ENSG00000171408
NCBI Gene
Aliases
bA472E5.1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NP563',5'-cyclic-AMP phosphodiesterase 7B4500Ensembl, GeneID, HGNC

Source UniProt

Patents66

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2025245188 A22025-11-2712Q9NP56Espacenet
EP 4641201 A22025-10-294270Q9NP56Espacenet
JP 2025517969 A2025-06-124270Q9NP56Espacenet
JP 2025032204 A2025-03-1133183Q9NP56Espacenet
JP 2025004127 A2025-01-1417Q9NP56Espacenet
KR 1020250007057 A2025-01-136Q9NP56Espacenet
JP 2024170507 A2024-12-106Q9NP56Espacenet
EP 4461818 A22024-11-1333183Q9NP56Espacenet
EP 4374872 A12024-05-29108Q9NP56Espacenet
JP 2024015430 A2024-02-016Q9NP56Espacenet

1 to 10 of 66

See all 66 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIPYRIDAMOLECHEMBL9323',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL
FLAVOXATECHEMBL1493Phosphodiesterase 7 inhibitorINHIBITORChEMBL
FLAVOXATE HYDROCHLORIDECHEMBL1200875Phosphodiesterase 7 inhibitorINHIBITORChEMBL
PENTOXIFYLLINECHEMBL6283',5'-cyclic phosphodiesterase inhibitorINHIBITORChEMBL

Trials135

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT07315139PENTOXIFYLLINEClinicalTrials.gov
NCT07252518PENTOXIFYLLINEClinicalTrials.gov
NCT07199504DIPYRIDAMOLEPHASE2/PHASE3ClinicalTrials.gov
NCT07088328PENTOXIFYLLINEClinicalTrials.gov
NCT07086794PENTOXIFYLLINEEARLY_PHASE1ClinicalTrials.gov
NCT07085806PENTOXIFYLLINEClinicalTrials.gov
NCT06998628PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06986031PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT06912763PENTOXIFYLLINEPHASE2ClinicalTrials.gov

1 to 10 of 135

See all 135 trials

NIH grants401

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDE7B papersNewest fiscal year
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)32025
P30CA086862Cancer Center Support Grant22025
P30EY014104P30 Core Grant for Vision Research22025
R01EY022305NEIGHBORHOOD Consortium for POAG Genetics22025
R01MH126929Latrophilin Function in Synapse Formation22025
ZIADE000380The role of stem cells in skeletal health and disease22025
P01AG078106Neuroimmunology of AD and CAA with focus on innate immunity and lymphatics12025
P20GM103418Kansas IDeA Network of Biomedical Research Excellence 512025
P30AG021332Wake Forest Claude D. Pepper OAIC - Renewal12025
P30AG072973University of Kansas Alzheimer's Disease Research Center (KU ADRC)12025

1 to 10 of 401Source NIH's project files

See all 401 nih grants

Papers379

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Astrocytic PDE7B Drives Blood-Brain Barrier Breakdown via Extracellular Vesicles in Demyelinating Disease.Glia202642708970PubTator, text miningPubMed
A compact five-gene immuno-fibrotic profile distinguishing systemic sclerosis subtypes with PXDN validated as a fibrosis-associated target.Front Immunol202642688363PubTator, text miningPubMed
Integrative analysis of single nucleotide polymorphism of PDE7B (rs2327669) with biopsychosocial and biochemical parameters in β-thalassemia major patients in Pakistani Cohort.Mol Biol Rep202642313217PubTator, text miningPubMed
Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells.Nat Immunol202642230957PubTator, text miningPubMed
Epigenetic regulation in a high-sugar environment (Review).Int J Mol Med202641860052PubTator, text miningPubMed
Epigenomic subtypes of late-onset Alzheimer's disease reveal distinct microglial signatures.Acta Neuropathol202641733741PubTator, text miningPubMed
Role and underlying mechanisms of miR‑200 family in breast cancer (Review).Int J Oncol202641716019PubTator, text miningPubMed
RETRACTION: Role and Mechanism of Circ-PDE7B in the Formation of Keloid.Int Wound J202540769516PubTator, text miningPubMed
Downregulation of CMIP contributes to preeclampsia development by impairing trophoblast function via the PDE7B-cAMP pathway.Cell Mol Life Sci202540372501PubTator, text miningPubMed
Chemical Space Exploration and Machine Learning-Based Screening of PDE7A Inhibitors.Pharmaceuticals (Basel)202540283882PubTator, text miningPubMed

1 to 10 of 379

See all 379 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/27115

GET https://conductscience.org/api/genes/v1/27115/patents?page=2