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Gene · 27181

SIGLEC8: sialic acid binding Ig like lectin 8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SIGLEC8: sialic acid binding Ig like lectin 8. Genes, record 27181. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27181

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Gene

Symbol
SIGLEC8
HGNC
Name
sialic acid binding Ig like lectin 8
HGNC
NCBI Gene ID
27181
NCBI Gene
HGNC ID
HGNC:10877
HGNC
Ensembl
ENSG00000105366
NCBI Gene
Aliases
MGC59785, SAF2, SIGLEC-8, SIGLEC8L
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NYZ4Sialic acid-binding Ig-like lectin 84995Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463513Q9NYZ4Espacenet
EP 4650780 A22025-11-195354Q9NYZ4Espacenet
EP 4641201 A22025-10-294948Q9NYZ4Espacenet
JP 2025529142 A2025-09-043962Q9NYZ4Espacenet
US 12371689 B22025-07-293962Q9NYZ4Espacenet
JP 2025517969 A2025-06-124948Q9NYZ4Espacenet
JP 2025517970 A2025-06-125354Q9NYZ4Espacenet
JP 2025515304 A2025-05-1442Q9NYZ4Espacenet
WO 2025093745 A12025-05-08300Q9NYZ4Espacenet
EP 4511394 A22025-02-2642Q9NYZ4Espacenet

1 to 10 of 26

See all 26 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
LIRENTELIMABCHEMBL4297878Sialic acid-binding Ig-like lectin 8 inhibitorINHIBITOR

Source ChEMBL

Trials12

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05528861LIRENTELIMABPHASE22024-09-27ClinicalTrials.gov
NCT05155085LIRENTELIMABPHASE22024-09-24ClinicalTrials.gov
NCT05152563LIRENTELIMABPHASE3ClinicalTrials.gov
NCT04856891LIRENTELIMABPHASE32024-01-02ClinicalTrials.gov
NCT04620811LIRENTELIMABPHASE32024-04-18ClinicalTrials.gov
NCT04322708LIRENTELIMABPHASE2/PHASE32024-01-02ClinicalTrials.gov
NCT04322604LIRENTELIMABPHASE32024-01-02ClinicalTrials.gov
NCT03664960LIRENTELIMABPHASE22024-02-28ClinicalTrials.gov
NCT03496571LIRENTELIMABPHASE22024-01-17ClinicalTrials.gov
NCT03436797LIRENTELIMABPHASE22024-01-23ClinicalTrials.gov

1 to 10 of 12

See all 12 trials

NIH grants613

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSIGLEC8 papersNewest fiscal year
ZIAAI001130Eosinophils and Eosinophil Activation in the Pathogenesis of Human Disease172025
U19AI070535Airway Inflammation and Airway Remodeling in Severe Asthma112025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease102025
U19AI070235Epithelial Genes in Allergic Inflammation102025
T32AI083216Northwestern University Allergy and Immunology Research (NUAIR) Program72025
U2CTR002818Data Management and Coordinating Center: Rare Diseases Clinical Research Network62025
P01HL136275Immune Cell Interactions in Atherosclerosis42025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center42025
R01AI124355Genetic and Immunological Dissection of Eosinophilic Esophagitis42025
ZIACL080004Laboratory Assessment of Patients with Hypereosinophilic Syndrome42025

1 to 10 of 613Source NIH's project files

See all 613 nih grants

Papers787

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Eosinophil subtypes in asthmatic patients treated with mepolizumab, omalizumab and dupilumab.ERJ Open Res202642440898PubTator, text miningPubMed
Resident eosinophils in patients with chronic obstructive pulmonary disease: a pilot study.Front Med (Lausanne)202642266944PubTator, text miningPubMed
Targeting immune dysregulation in chronic spontaneous urticaria: beyond antihistamines.Korean J Intern Med202642128382PubTator, text miningPubMed
Treatment of eosinophilic esophagitis with immune modulating agents.Allergy Asthma Proc202642050831PubTator, text miningPubMed
Design, synthesis and biophysical evaluation of sialyl triazoles as glycomimetic ligands for Siglec-8. Sulfonate is a viable replacement for sulfate.Eur J Med Chem202642030707PubTator, text miningPubMed
Immunological Basis of Chronic Spontaneous Urticaria: Immunoglobulin E and Beyond.Yonsei Med J202641914312PubTator, text miningPubMed
Understanding Eosinophil Heterogeneity: The Known and Unknown.Cells202641892353PubTator, text miningPubMed
Eosinophilia and Risk of Thrombosis and Mortality in Hospitalized Patients: A Retrospective Cohort Study.Life (Basel)202641752879PubTator, text miningPubMed
The Role of Mucins in Esophageal Inflammatory Diseases.J Pers Med202641745385PubTator, text miningPubMed
An Assessment of Melatonin Levels in the Saliva of Patients with Chronic Urticaria in Comparison with Their Sleep Quality and Dermatologic Quality of Life.Clin Pract202641744519PubTator, text miningPubMed

1 to 10 of 787

See all 787 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/27181

GET https://conductscience.org/api/genes/v1/27181/patents?page=2