Gene · 27181
SIGLEC8: sialic acid binding Ig like lectin 8
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SIGLEC8: sialic acid binding Ig like lectin 8. Genes, record 27181. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27181
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NYZ4 | Sialic acid-binding Ig-like lectin 8 | 499 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63513 | Q9NYZ4 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5354 | Q9NYZ4 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4948 | Q9NYZ4 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3962 | Q9NYZ4 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3962 | Q9NYZ4 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4948 | Q9NYZ4 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5354 | Q9NYZ4 | Espacenet |
| JP 2025515304 A | 2025-05-14 | 42 | Q9NYZ4 | Espacenet |
| WO 2025093745 A1 | 2025-05-08 | 300 | Q9NYZ4 | Espacenet |
| EP 4511394 A2 | 2025-02-26 | 42 | Q9NYZ4 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| LIRENTELIMAB | CHEMBL4297878 | Sialic acid-binding Ig-like lectin 8 inhibitor | INHIBITOR |
Source ChEMBL
Trials12
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05528861 | LIRENTELIMAB | PHASE2 | 2024-09-27 | ClinicalTrials.gov |
| NCT05155085 | LIRENTELIMAB | PHASE2 | 2024-09-24 | ClinicalTrials.gov |
| NCT05152563 | LIRENTELIMAB | PHASE3 | ClinicalTrials.gov | |
| NCT04856891 | LIRENTELIMAB | PHASE3 | 2024-01-02 | ClinicalTrials.gov |
| NCT04620811 | LIRENTELIMAB | PHASE3 | 2024-04-18 | ClinicalTrials.gov |
| NCT04322708 | LIRENTELIMAB | PHASE2/PHASE3 | 2024-01-02 | ClinicalTrials.gov |
| NCT04322604 | LIRENTELIMAB | PHASE3 | 2024-01-02 | ClinicalTrials.gov |
| NCT03664960 | LIRENTELIMAB | PHASE2 | 2024-02-28 | ClinicalTrials.gov |
| NCT03496571 | LIRENTELIMAB | PHASE2 | 2024-01-17 | ClinicalTrials.gov |
| NCT03436797 | LIRENTELIMAB | PHASE2 | 2024-01-23 | ClinicalTrials.gov |
1 to 10 of 12
See all 12 trialsNIH grants613
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SIGLEC8 papers | Newest fiscal year |
|---|---|---|---|
| ZIAAI001130 | Eosinophils and Eosinophil Activation in the Pathogenesis of Human Disease | 17 | 2025 |
| U19AI070535 | Airway Inflammation and Airway Remodeling in Severe Asthma | 11 | 2025 |
| P30DK078392 | Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease | 10 | 2025 |
| U19AI070235 | Epithelial Genes in Allergic Inflammation | 10 | 2025 |
| T32AI083216 | Northwestern University Allergy and Immunology Research (NUAIR) Program | 7 | 2025 |
| U2CTR002818 | Data Management and Coordinating Center: Rare Diseases Clinical Research Network | 6 | 2025 |
| P01HL136275 | Immune Cell Interactions in Atherosclerosis | 4 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 4 | 2025 |
| R01AI124355 | Genetic and Immunological Dissection of Eosinophilic Esophagitis | 4 | 2025 |
| ZIACL080004 | Laboratory Assessment of Patients with Hypereosinophilic Syndrome | 4 | 2025 |
1 to 10 of 613Source NIH's project files
See all 613 nih grantsPapers787
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Eosinophil subtypes in asthmatic patients treated with mepolizumab, omalizumab and dupilumab. | ERJ Open Res | 2026 | 42440898 | PubTator, text mining | PubMed |
| Resident eosinophils in patients with chronic obstructive pulmonary disease: a pilot study. | Front Med (Lausanne) | 2026 | 42266944 | PubTator, text mining | PubMed |
| Targeting immune dysregulation in chronic spontaneous urticaria: beyond antihistamines. | Korean J Intern Med | 2026 | 42128382 | PubTator, text mining | PubMed |
| Treatment of eosinophilic esophagitis with immune modulating agents. | Allergy Asthma Proc | 2026 | 42050831 | PubTator, text mining | PubMed |
| Design, synthesis and biophysical evaluation of sialyl triazoles as glycomimetic ligands for Siglec-8. Sulfonate is a viable replacement for sulfate. | Eur J Med Chem | 2026 | 42030707 | PubTator, text mining | PubMed |
| Immunological Basis of Chronic Spontaneous Urticaria: Immunoglobulin E and Beyond. | Yonsei Med J | 2026 | 41914312 | PubTator, text mining | PubMed |
| Understanding Eosinophil Heterogeneity: The Known and Unknown. | Cells | 2026 | 41892353 | PubTator, text mining | PubMed |
| Eosinophilia and Risk of Thrombosis and Mortality in Hospitalized Patients: A Retrospective Cohort Study. | Life (Basel) | 2026 | 41752879 | PubTator, text mining | PubMed |
| The Role of Mucins in Esophageal Inflammatory Diseases. | J Pers Med | 2026 | 41745385 | PubTator, text mining | PubMed |
| An Assessment of Melatonin Levels in the Saliva of Patients with Chronic Urticaria in Comparison with Their Sleep Quality and Dermatologic Quality of Life. | Clin Pract | 2026 | 41744519 | PubTator, text mining | PubMed |
1 to 10 of 787
See all 787 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/27181
GET https://conductscience.org/api/genes/v1/27181/patents?page=2