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Gene · 2931

GSK3A: glycogen synthase kinase 3 alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GSK3A: glycogen synthase kinase 3 alpha. Genes, record 2931. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2931

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Gene

Symbol
GSK3A
HGNC
Name
glycogen synthase kinase 3 alpha
HGNC
NCBI Gene ID
2931
NCBI Gene
HGNC ID
HGNC:4616
HGNC
Ensembl
ENSG00000105723
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49840Glycogen synthase kinase-3 alpha4832Ensembl, GeneID, HGNC

Source UniProt

Patents67

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19552P49840Espacenet
EP 4641201 A22025-10-29388P49840Espacenet
JP 2025517969 A2025-06-12388P49840Espacenet
JP 2025517970 A2025-06-12552P49840Espacenet
US 11892452 B22024-02-06131P49840Espacenet
JP 2023123507 A2023-09-0511P49840Espacenet
US 11564998 B22023-01-314727P49840Espacenet
US 11564998 B22023-01-318099P49840Espacenet
US 11446398 B22022-09-2035587P49840Espacenet
US 11446398 B22022-09-2035589P49840Espacenet

1 to 10 of 67

See all 67 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZD-1080CHEMBL1969664Glycogen synthase kinase-3 inhibitorINHIBITORChEMBL
LITHIUM CARBONATECHEMBL1200826Glycogen synthase kinase-3 inhibitorINHIBITORChEMBL
LITHIUM CITRATECHEMBL2103738Glycogen synthase kinase-3 inhibitorINHIBITORChEMBL
LITHIUM CITRATE ANHYDROUSCHEMBL1201170Glycogen synthase kinase-3 inhibitorINHIBITORChEMBL
LY-2090314CHEMBL362558Glycogen synthase kinase-3 alpha inhibitorINHIBITORChEMBL

Trials90

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07540338LITHIUM CARBONATEPHASE1/PHASE2ClinicalTrials.gov
NCT06789783LITHIUM CARBONATEPHASE2/PHASE3ClinicalTrials.gov
NCT06424613LITHIUM CARBONATEClinicalTrials.gov
NCT06184581LITHIUM CARBONATEPHASE4ClinicalTrials.gov
NCT06008249LITHIUM CARBONATEPHASE3ClinicalTrials.gov
NCT05973786LITHIUM CARBONATEPHASE3ClinicalTrials.gov
NCT05923476LITHIUM CARBONATEEARLY_PHASE1ClinicalTrials.gov
NCT05913947LITHIUM CARBONATEPHASE4ClinicalTrials.gov
NCT05814640LITHIUM CARBONATEPHASE1/PHASE2ClinicalTrials.gov
NCT05618587LITHIUM CARBONATEPHASE22025-03-05ClinicalTrials.gov

1 to 10 of 90

See all 90 trials

NIH grants2,118

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGSK3A papersNewest fiscal year
P30CA016672Cancer Center Support Grant282025
P30CA076292Moffitt Cancer Center Support Grant92025
R01HL133290Signaling Mechanisms Governing Myocardial Fibrosis in Diseased Heart82025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center62025
R01HL143074Novel Mechanisms of Cardiac Function and Dysfunction62025
P30CA068485Cancer Center Support Grant52025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
P30DK036836Diabetes Research Center52025
P30CA016058Cancer Center Support Grant42025
P30CA016086Cancer Center Support Grant42025

1 to 10 of 2,118Source NIH's project files

See all 2,118 nih grants

Papers2,889

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CREB1 and GSK3 Isoforms as Potential Adaptive Signaling Nodes in PI3K/Akt/mTOR Inhibitor Treated Philadelphia Chromosome-Positive B-ALL.Int J Mol Sci202642794727PubTator, text miningPubMed
Deep learning-assisted virtual screening of a large chemical library for selective GSK3β inhibitors.Mol Divers202642584522PubTator, text miningPubMed
Navigating the Complexity: A Comprehensive Review of GSK-3 Inhibition in Regenerative Medicine.Med Res Rev202642559793PubTator, text miningPubMed
A universal 6iL/E4 culture system for deriving and maintaining embryonic stem cells across mammalian species.Cell Res202642443522PubTator, text miningPubMed
Integrated Proteomic and Phosphoproteomic Profiling Reveals Mechanisms of Bisphenol A Induced Placental Toxicity.Chem Res Toxicol202642440269PubTator, text miningPubMed
Integrated machine learning, molecular docking, and molecular dynamics simulations for in silico identification of GSK3β inhibitors for Alzheimer's disease.Sci Rep202642365084PubTator, text miningPubMed
Rosmarinic acid as a potential GSK3β inhibitor for autism spectrum disorder: insights from an integrative in silico study.In Silico Pharmacol202642064451PubTator, text miningPubMed
Dual-target antioxidant potential of benzimidazole-based thiazine and N-tosylated analogues: computational insights into human 11β-HSD1 and Leishmania GSK-3α inhibition.Comput Biol Med202642061289PubTator, text miningPubMed
GSK3α functions as a stemness checkpoint across multiple stem cell states.Cell Res202641951855PubTator, text miningPubMed
Wnt-dependent Frizzled clustering is required for Dishevelled phosphorylation but insufficient for β-catenin stabilization.Sci Signal202641945658PubTator, text miningPubMed

1 to 10 of 2,889

See all 2,889 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2931

GET https://conductscience.org/api/genes/v1/2931/patents?page=2