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Gene · 2977

GUCY1A2: guanylate cyclase 1 soluble subunit alpha 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GUCY1A2: guanylate cyclase 1 soluble subunit alpha 2. Genes, record 2977. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2977

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Gene

Symbol
GUCY1A2
HGNC
Name
guanylate cyclase 1 soluble subunit alpha 2
HGNC
NCBI Gene ID
2977
NCBI Gene
HGNC ID
HGNC:4684
HGNC
Ensembl
ENSG00000152402
NCBI Gene
Aliases
GC-SA2, GUC1A2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P33402Guanylate cyclase soluble subunit alpha-27320Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448584P33402Espacenet
EP 4641201 A22025-10-2918409P33402Espacenet
JP 2025517969 A2025-06-1218409P33402Espacenet
EP 4491229 A22025-01-1589P33402Espacenet
WO 2024230934 A12024-11-14214P33402Espacenet
US 11446398 B22022-09-2036966P33402Espacenet
JP 2022524081 A2022-04-27139937P33402Espacenet
KR 1020210128370 A2021-10-2617P33402Espacenet
KR 1020210125457 A2021-10-183P33402Espacenet
US 11078247 B22021-08-034811P33402Espacenet

1 to 10 of 20

See all 20 patents

Drugs16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATACIGUATCHEMBL2107729Soluble guanylate cyclase activatorACTIVATORChEMBL
CINACIGUATCHEMBL1236936Soluble guanylate cyclase activatorACTIVATORChEMBL
ISOSORBIDE DINITRATECHEMBL6622Soluble guanylate cyclase activatorACTIVATORChEMBL
ISOSORBIDE MONONITRATECHEMBL1311Soluble guanylate cyclase activatorACTIVATORChEMBL
METHYLENE BLUE ANHYDROUSCHEMBL405110Soluble guanylate cyclase inhibitorINHIBITORChEMBL
METHYLENE BLUE CATIONCHEMBL191083Soluble guanylate cyclase inhibitorINHIBITORChEMBL
NITRIC OXIDECHEMBL1200689Soluble guanylate cyclase activatorACTIVATORChEMBL
NITROGLYCERINCHEMBL730Soluble guanylate cyclase activatorACTIVATORChEMBL
NITROPRUSSIDECHEMBL2097081Soluble guanylate cyclase activatorACTIVATORChEMBL
OLINCIGUATCHEMBL4297616Soluble guanylate cyclase positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 16

See all 16 drugs

Trials316

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603037SODIUM NITROPRUSSIDEClinicalTrials.gov
NCT07585201NITROGLYCERINClinicalTrials.gov
NCT07444398VERICIGUATPHASE1ClinicalTrials.gov
NCT07431294NITROGLYCERINPHASE1ClinicalTrials.gov
NCT07268638PRALICIGUATPHASE2ClinicalTrials.gov
NCT07214129NITROGLYCERINClinicalTrials.gov
NCT07121634ISOSORBIDE MONONITRATEClinicalTrials.gov
NCT07099144NITRIC OXIDEClinicalTrials.gov
NCT07047547VERICIGUATClinicalTrials.gov
NCT06950294NITRIC OXIDEEARLY_PHASE1ClinicalTrials.gov

1 to 10 of 316

See all 316 trials

NIH grants222

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGUCY1A2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant22025
P30AI027763UCSF-Bay Area Center for AIDS Research12025
P30CA006973Regional Oncology Research Center12025
P30CA008748Cancer Center Support Grant12025
P30CA014520UW Comprehensive Cancer Center Support12025
P30CA043703Case Comprehensive Cancer Center Support Grant12025
P30CA068485Cancer Center Support Grant12025
P30CA086862Cancer Center Support Grant12025
P30CA093373Cancer Center Support Grant P3012025
P30CA118100University of New Mexico Cancer Center Support Grant12025

1 to 10 of 222Source NIH's project files

See all 222 nih grants

Papers244

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A single-cell and spatial transcriptomic atlas of human tuberculous constrictive pericardium.EBioMedicine202641875497PubTator, text miningPubMed
Multi-Omics Mechanism of Chronic Gout Arthritis and Discovery of the Thyroid Hormone-AMPK-Taurine Metabolic Axis.Cells202541511324PubTator, text miningPubMed
CXCL8 is essential for cervical cancer cell acquired radioresistance and acts as a promising therapeutic target in cervical cancer.Sci Rep202540596054PubTator, text miningPubMed
Exonic CircGUCY1A2 inhibits pulmonary artery smooth muscle cells phenotypic switching via regulating O-glycosylation of COL3A1 in pulmonary hypertension.Eur J Pharmacol202539914785PubTator, text miningPubMed
Soluble Guanylate Cyclase Dysfunction and Nitric Oxide Pathway in Chronic Rhinosinusitis With Nasal Polyps: Predictive Markers for Postoperative Recurrence.Am J Rhinol Allergy202539473384PubTator, text miningPubMed
Differential quantification of alternative splicing events on spliced pangenome graphs.PLoS Comput Biol202439652592PubTator, text miningPubMed
[Construction and validation of an immune prognostic risk model in oral squamous cell carcinoma].Shanghai Kou Qiang Yi Xue202439478389PubTator, text miningPubMed
Acting mechanism and clinical significance of hsa_circ_0005927 in the invasion and metastasis of gastric cancer.J Cancer202438947400PubTator, text miningPubMed
Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas.Sci Rep202438714721PubTator, text miningPubMed
Heterozygous gain of function variant in GUCY1A2 may cause autonomous ovarian hyperfunction.Eur J Endocrinol202438578777PubTator, text miningPubMed

1 to 10 of 244

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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