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Gene · 2982

GUCY1A1: guanylate cyclase 1 soluble subunit alpha 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GUCY1A1: guanylate cyclase 1 soluble subunit alpha 1. Genes, record 2982. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2982

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Gene

Symbol
GUCY1A1
HGNC
Name
guanylate cyclase 1 soluble subunit alpha 1
HGNC
NCBI Gene ID
2982
NCBI Gene
HGNC ID
HGNC:4685
HGNC
Ensembl
ENSG00000164116
NCBI Gene
Aliases
GC-S-alpha-1, GC-SA3, GCS-alpha-3, GUC1A3, GUCA3, GUCSA3, GUCY1A3, MYMY6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q02108Guanylate cyclase soluble subunit alpha-169012Ensembl, GeneID, HGNC

Source UniProt

Patents76

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448585Q02108Espacenet
JP 2026004568 A2026-01-1448586Q02108Espacenet
JP 2026004568 A2026-01-1448587Q02108Espacenet
JP 2026004568 A2026-01-1448588Q02108Espacenet
JP 2026004568 A2026-01-1448589Q02108Espacenet
EP 4641201 A22025-10-293311Q02108Espacenet
JP 2025517969 A2025-06-123311Q02108Espacenet
JP 2025032204 A2025-03-1129459Q02108Espacenet
JP 2025032204 A2025-03-1129460Q02108Espacenet
JP 2025032204 A2025-03-1129462Q02108Espacenet

1 to 10 of 76

See all 76 patents

Drugs16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATACIGUATCHEMBL2107729Soluble guanylate cyclase activatorACTIVATORChEMBL
CINACIGUATCHEMBL1236936Soluble guanylate cyclase activatorACTIVATORChEMBL
ISOSORBIDE DINITRATECHEMBL6622Soluble guanylate cyclase activatorACTIVATORChEMBL
ISOSORBIDE MONONITRATECHEMBL1311Soluble guanylate cyclase activatorACTIVATORChEMBL
METHYLENE BLUE ANHYDROUSCHEMBL405110Soluble guanylate cyclase inhibitorINHIBITORChEMBL
METHYLENE BLUE CATIONCHEMBL191083Soluble guanylate cyclase inhibitorINHIBITORChEMBL
NITRIC OXIDECHEMBL1200689Soluble guanylate cyclase activatorACTIVATORChEMBL
NITROGLYCERINCHEMBL730Soluble guanylate cyclase activatorACTIVATORChEMBL
NITROPRUSSIDECHEMBL2097081Soluble guanylate cyclase activatorACTIVATORChEMBL
OLINCIGUATCHEMBL4297616Soluble guanylate cyclase positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 16

See all 16 drugs

Trials316

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603037SODIUM NITROPRUSSIDEClinicalTrials.gov
NCT07585201NITROGLYCERINClinicalTrials.gov
NCT07444398VERICIGUATPHASE1ClinicalTrials.gov
NCT07431294NITROGLYCERINPHASE1ClinicalTrials.gov
NCT07268638PRALICIGUATPHASE2ClinicalTrials.gov
NCT07214129NITROGLYCERINClinicalTrials.gov
NCT07121634ISOSORBIDE MONONITRATEClinicalTrials.gov
NCT07099144NITRIC OXIDEClinicalTrials.gov
NCT07047547VERICIGUATClinicalTrials.gov
NCT06950294NITRIC OXIDEEARLY_PHASE1ClinicalTrials.gov

1 to 10 of 316

See all 316 trials

NIH grants892

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGUCY1A1 papersNewest fiscal year
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal62025
P30DK063491Diabetes Research Center (DRC)52025
P30ES010126UNC Center for Environmental Health and Susceptibility52025
ZIAHL006170Cardiovascular Genomics and Bioinformatics projects42025
P30CA008748Cancer Center Support Grant32025
P30DK056350Nutrition Obesity Research Center (NORC)32025
P30EY008126Core Grant in Vision Research32025
ZIAHL006001Framingham Project/Levy32025
P30CA016056Roswell Park Cancer Center Support Grant22025
P30DK020572Michigan Diabetes Research Center (MDRC)22025

1 to 10 of 892Source NIH's project files

See all 892 nih grants

Papers525

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor.Sci Adv202641931622PubTator, text miningPubMed
Chaperonin in health and disease.Mol Biomed202641920440PubTator, text miningPubMed
PAH-former: Transfer learning for efficient discovery of pulmonary arterial hypertension-associated genes.PLoS One202641790620PubTator, text miningPubMed
Integrated analysis and validation of metabolism-related genes in lung transplantation-induced cold ischemia/ reperfusion injury.PeerJ202641769389PubTator, text miningPubMed
Integrative RNA-Seq and TCGA-BRCA Analyses Highlight the Role of LINC01133 in Triple-Negative Breast Cancer.Biomedicines202641751167PubTator, text miningPubMed
Moyamoya Vasculopathy and Atypical Moyamoya-like Patterns: Insights into Diagnosis and Therapeutic Implications.NeuroSci202641718156PubTator, text miningPubMed
Molecular and multimodal biomarkers in Moyamoya disease: from pathogenic mechanisms to clinical translation.Eur J Med Res202641484923PubTator, text miningPubMed
Precision medicine in Moyamoya vasculopathy.Curr Opin Neurol202641355354PubTator, text miningPubMed
In Vitro retinal ganglion cell differentiation and enrichment under the scope: do subtypes matter?Front Cell Dev Biol202541777802PubTator, text miningPubMed
Multi-omics research on moyamoya disease: current perspectives and future directions.Nutr Metab (Lond)202541354962PubTator, text miningPubMed

1 to 10 of 525

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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