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Gene · 2983

GUCY1B1: guanylate cyclase 1 soluble subunit beta 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GUCY1B1: guanylate cyclase 1 soluble subunit beta 1. Genes, record 2983. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2983

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Gene

Symbol
GUCY1B1
HGNC
Name
guanylate cyclase 1 soluble subunit beta 1
HGNC
NCBI Gene ID
2983
NCBI Gene
HGNC ID
HGNC:4687
HGNC
Ensembl
ENSG00000061918
NCBI Gene
Aliases
GC-S-beta-1, GC-SB3, GUC1B3, GUCB3, GUCSB3, GUCY1B3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q02153Guanylate cyclase soluble subunit beta-161914Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448590Q02153Espacenet
EP 4650780 A22025-11-192349Q02153Espacenet
EP 4641201 A22025-10-291921Q02153Espacenet
JP 2025517969 A2025-06-121921Q02153Espacenet
JP 2025517970 A2025-06-122349Q02153Espacenet
EP 4491229 A22025-01-1591Q02153Espacenet
WO 2024230934 A12024-11-14216Q02153Espacenet
US 11446398 B22022-09-2036978Q02153Espacenet
JP 2022524081 A2022-04-27139949Q02153Espacenet
US 11078247 B22021-08-034813Q02153Espacenet

1 to 10 of 26

See all 26 patents

Drugs16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATACIGUATCHEMBL2107729Soluble guanylate cyclase activatorACTIVATORChEMBL
CINACIGUATCHEMBL1236936Soluble guanylate cyclase activatorACTIVATORChEMBL
ISOSORBIDE DINITRATECHEMBL6622Soluble guanylate cyclase activatorACTIVATORChEMBL
ISOSORBIDE MONONITRATECHEMBL1311Soluble guanylate cyclase activatorACTIVATORChEMBL
METHYLENE BLUE ANHYDROUSCHEMBL405110Soluble guanylate cyclase inhibitorINHIBITORChEMBL
METHYLENE BLUE CATIONCHEMBL191083Soluble guanylate cyclase inhibitorINHIBITORChEMBL
NITRIC OXIDECHEMBL1200689Soluble guanylate cyclase activatorACTIVATORChEMBL
NITROGLYCERINCHEMBL730Soluble guanylate cyclase activatorACTIVATORChEMBL
NITROPRUSSIDECHEMBL2097081Soluble guanylate cyclase activatorACTIVATORChEMBL
OLINCIGUATCHEMBL4297616Soluble guanylate cyclase positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 16

See all 16 drugs

Trials316

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603037SODIUM NITROPRUSSIDEClinicalTrials.gov
NCT07585201NITROGLYCERINClinicalTrials.gov
NCT07444398VERICIGUATPHASE1ClinicalTrials.gov
NCT07431294NITROGLYCERINPHASE1ClinicalTrials.gov
NCT07268638PRALICIGUATPHASE2ClinicalTrials.gov
NCT07214129NITROGLYCERINClinicalTrials.gov
NCT07121634ISOSORBIDE MONONITRATEClinicalTrials.gov
NCT07099144NITRIC OXIDEClinicalTrials.gov
NCT07047547VERICIGUATClinicalTrials.gov
NCT06950294NITRIC OXIDEEARLY_PHASE1ClinicalTrials.gov

1 to 10 of 316

See all 316 trials

NIH grants577

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGUCY1B1 papersNewest fiscal year
P30ES010126UNC Center for Environmental Health and Susceptibility42025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal42025
P30DK056350Nutrition Obesity Research Center (NORC)32025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment32025
P30DK063491Diabetes Research Center (DRC)22025
P30EY008126Core Grant in Vision Research22025
P30EY014104P30 Core Grant for Vision Research22025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION22025
R01DK075787Biological Insights from Genetic Investigation of ANthropometric Traits (GIANT) Across the Allelic Spectrum22025
R01EY013178Novel Glaucoma Diagnostics for Structure and Function.22025

1 to 10 of 577Source NIH's project files

See all 577 nih grants

Papers318

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of a shared blood-brain transcriptomic signature in Parkinson's disease using bioinformatic and network pharmacology approaches.Neuroscience202642826760PubTator, text miningPubMed
Bioinformatics identification of candidate biomarkers associated with T cell proliferation in atherosclerosis via WGCNA and machine learning.J Cardiothorac Surg202642464325PubTator, text miningPubMed
Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor.Sci Adv202641931622PubTator, text miningPubMed
PAH-former: Transfer learning for efficient discovery of pulmonary arterial hypertension-associated genes.PLoS One202641790620PubTator, text miningPubMed
Integrated analysis and validation of metabolism-related genes in lung transplantation-induced cold ischemia/ reperfusion injury.PeerJ202641769389PubTator, text miningPubMed
The Impact of Maternal Diabetes and Hypothyroidism on Signaling Pathway Activation and Gene Expression in Fetal Mesenchymal Stem Cells.Biomedicines202641751334PubTator, text miningPubMed
Regulon Reconstruction Uncovers Novel Deregulated Factors in Alzheimer's Disease.Mol Neurobiol202641729360PubTator, text miningPubMed
Exploring the PLD1-tau interaction in Frontotemporal Dementia.bioRxiv202641726972PubTator, text miningPubMed
TFE3 fusion proteins drive TFE3 rearranged renal cell carcinoma progression via PGC-1α-mediated fatty acid oxidation.Front Immunol202641716419PubTator, text miningPubMed
Sodium valproate drives propionylation-mediated epigenetic reprogramming to enhance mesothelin CAR-T cell therapy in solid tumors.Mol Ther202641383012PubTator, text miningPubMed

1 to 10 of 318

See all 318 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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