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Gene · 2984

GUCY2C: guanylate cyclase 2C

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GUCY2C: guanylate cyclase 2C. Genes, record 2984. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2984

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Gene

Symbol
GUCY2C
HGNC
Name
guanylate cyclase 2C
HGNC
NCBI Gene ID
2984
NCBI Gene
HGNC ID
HGNC:4688
HGNC
Ensembl
ENSG00000070019
NCBI Gene
Aliases
DIAR6, GC-C, GCC, GUC2C, HSER, MECIL, MUCIL, STAR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P25092Guanylyl cyclase C1,0733Ensembl, GeneID, HGNC

Source UniProt

Patents92

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4745230 A22026-05-2033P25092Espacenet
JP 2026510484 A2026-04-0776P25092Espacenet
JP 2026004568 A2026-01-1448594P25092Espacenet
EP 4650780 A22025-11-191848P25092Espacenet
EP 4641201 A22025-10-291428P25092Espacenet
JP 2025529142 A2025-09-041896P25092Espacenet
JP 2025525885 A2025-08-071P25092Espacenet
US 12371689 B22025-07-291896P25092Espacenet
KR 1020250099224 A2025-07-0176P25092Espacenet
JP 2025517969 A2025-06-121428P25092Espacenet

1 to 10 of 92

See all 92 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DOLCANATIDECHEMBL3545122Heat-stable enterotoxin receptor agonistAGONISTChEMBL
INDUSATUMAB VEDOTINCHEMBL4298045Heat-stable enterotoxin receptor binding agentBINDING AGENTChEMBL
LINACLOTIDECHEMBL3301675Heat-stable enterotoxin receptor agonistAGONISTChEMBL
PLECANATIDECHEMBL2103867Heat-stable enterotoxin receptor agonistAGONISTChEMBL

Trials38

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07569419LINACLOTIDEEARLY_PHASE1ClinicalTrials.gov
NCT05760313LINACLOTIDEPHASE22026-01-06ClinicalTrials.gov
NCT05151328PLECANATIDEPHASE3ClinicalTrials.gov
NCT05137145LINACLOTIDEClinicalTrials.gov
NCT04804267LINACLOTIDEPHASE3ClinicalTrials.gov
NCT04110145LINACLOTIDEPHASE22022-04-26ClinicalTrials.gov
NCT04026113LINACLOTIDEPHASE32024-11-26ClinicalTrials.gov
NCT03796884LINACLOTIDEPHASE2ClinicalTrials.gov
NCT03596905PLECANATIDEPHASE22025-12-31ClinicalTrials.gov
NCT03471728LINACLOTIDEClinicalTrials.gov

1 to 10 of 38

See all 38 trials

NIH grants579

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGUCY2C papersNewest fiscal year
P30CA056036Translational Research in Cancer522025
T32GM008562Clinical Pharmacology Training Program342025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease82025
P30DK034854Integrated Epithelial and Muscosal Biology52025
RC2DK118640COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository52025
P30CA016672Cancer Center Support Grant42025
R01DK080834Inhibition of an Apical cAMP/cGMP Transporter (MRP4) in the Gut Induces Diarrhea42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA068485Cancer Center Support Grant32025
P30DK058404Molecular and Cellular Basis for Digestive Diseases32025

1 to 10 of 579Source NIH's project files

See all 579 nih grants

Papers1,157

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Phase I Study of PF-07062119, an Anti-GUCY2C/Anti-CD3 Bispecific Fc Antibody, in Patients with Advanced Gastrointestinal Cancers.Cancer Res Commun202642696650PubTator, text miningPubMed
Human bronchial air-liquid interface responses to nebulised protease exposure.Front Immunol202642630249PubTator, text miningPubMed
Isolation of Novel Fully Human Single-Domain Antibodies Targeting GUCY2C from a Heavy-Chain-Only Transgenic Mouse Platform.Technol Cancer Res Treat202642579767PubTator, text miningPubMed
Targeting molecular and genetic pathways driving tumorigenesis for precision therapy in colorectal cancer.Cancer Biol Ther202642502958PubTator, text miningPubMed
Nonarmored GCC-Targeting CAR T-cell Therapy Demonstrates Significant Efficacy in Patients with Advanced Colorectal Cancer.Clin Cancer Res202642467218PubTator, text miningPubMed
Next-generation precision oncology in microsatellite stable colorectal cancer: integrated targeting beyond RAS and RAF.ESMO Open202642462280PubTator, text miningPubMed
Establishing scientific confidence: human biological relevance of reconstructed human respiratory epithelium (RHRE) for assessing respiratory effects.Front Toxicol202642344759PubTator, text miningPubMed
De novo activating GUCY2C variant with prenatal bowel dilatation, neonatal functional obstruction, and reversible intestinal failure: A case report.Intest Fail202642318326PubTator, text miningPubMed
Guanylyl Cyclase 2C-Targeted Chimeric Antigen Receptor T-Cell Therapy in Patients With Metastatic Colorectal Cancer.J Clin Oncol202642241671PubTator, text miningPubMed
Sex-specific regulation of angiogenin in Alzheimer's disease.Mol Psychiatry202642230965PubTator, text miningPubMed

1 to 10 of 1,157

See all 1,157 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2984

GET https://conductscience.org/api/genes/v1/2984/patents?page=2