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Gene · 3061

HCRTR1: hypocretin receptor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HCRTR1: hypocretin receptor 1. Genes, record 3061. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3061

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Gene

Symbol
HCRTR1
HGNC
Name
hypocretin receptor 1
HGNC
NCBI Gene ID
3061
NCBI Gene
HGNC ID
HGNC:4848
HGNC
Ensembl
ENSG00000121764
NCBI Gene
Aliases
ORXR1, OX1R, OXR1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43613Orexin/Hypocretin receptor type 142514Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1044O43613Espacenet
WO 2026019942 A22026-01-22828O43613Espacenet
WO 2026004642 A2026-01-0261O43613Espacenet
EP 4640849 A22025-10-291401O43613Espacenet
EP 4641201 A22025-10-299605O43613Espacenet
JP 2025529142 A2025-09-041924O43613Espacenet
US 12371689 B22025-07-291924O43613Espacenet
JP 2025519096 A2025-06-241401O43613Espacenet
JP 2025517969 A2025-06-129605O43613Espacenet
EP 4311832 A12024-01-313O43613Espacenet

1 to 10 of 32

See all 32 patents

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALMOREXANTCHEMBL455136Orexin receptor antagonistANTAGONISTChEMBL
DARIDOREXANTCHEMBL4297590Orexin receptor antagonistANTAGONISTChEMBL
DARIDOREXANTCHEMBL4297590Orexin receptor 1 antagonistANTAGONISTChEMBL
DARIDOREXANT HYDROCHLORIDECHEMBL4650216Orexin receptor 1 antagonistANTAGONISTChEMBL
FILOREXANTCHEMBL2107822Orexin receptor antagonistANTAGONISTChEMBL
LEMBOREXANTCHEMBL3545367Orexin receptor 1 antagonistANTAGONISTChEMBL
ORN-0829 HYDRATECHEMBL4650522Orexin receptor antagonistANTAGONISTChEMBL
SB-649868CHEMBL1272307Orexin receptor 1 antagonistANTAGONISTChEMBL
SUVOREXANTCHEMBL1083659Orexin receptor antagonistANTAGONISTChEMBL

Trials91

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

1 to 10 of 91

See all 91 trials

NIH grants535

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHCRTR1 papersNewest fiscal year
R01AG050518Hypocretin/orexin modulation of cognitive correlates of brain aging32025
R01HL122010Decrypting Variants of Uncertain Significance in Long-QT Syndrome32025
T32DA007237Neurobiology of Addiction Training Program32025
T32NS007413Training Program in Neurodevelopmental Disabilities32025
I01BX001374Neural Basis of Individual Differences in Fear Extinction22025
P30AG072975Rush Alzheimer's Disease Research Center22025
P30ES019776HERCULES: Exposome Research Center22025
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology22025
T32AA007456NEUROPSYCHOPHARMACOLOGY: MULTIDISCIPLINARY TRAINING22025
T32GM008425Indiana University Comprehensive Training in Clinical Pharmacology22025

1 to 10 of 535Source NIH's project files

See all 535 nih grants

Papers869

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Thymosin Alpha-1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis.Adv Sci (Weinh)202642693587PubTator, text miningPubMed
Beyond traditional sleeping pills: safety, efficacy and multidisease potential of three approved orexin receptor antagonists.Front Psychiatry202642683191PubTator, text miningPubMed
Research Progress and Future Perspectives of Orexin Receptor Antagonists in Insomnia Therapy.Molecules202642653878PubTator, text miningPubMed
The orexin system as a pharmacological target in inflammation: peripheral mechanisms and safety implications.Front Pharmacol202642609337PubTator, text miningPubMed
Probing chemical space and conformational changes for subtype-selective orexin receptor antagonists.RSC Med Chem202642592024PubTator, text miningPubMed
Involvement of the cannabinoid receptors of the basolateral amygdala in the orexin A-mediated modulation of the stress-induced analgesia.Neuropharmacology202642526687PubTator, text miningPubMed
Lateral hypothalamic orexinergic neurons as central mediators of pain modulation and non-pharmacological analgesia.Front Pharmacol202642460012PubTator, text miningPubMed
A Scoping Review of Orexin Antagonists in Post-Traumatic Stress Disorder: Modulating Sleep, Stress, and Fear Circuits.Mil Med202642391109PubTator, text miningPubMed
A Dimer for Dinner: The Impact of GHS-R1a Heterodimerization on Feeding Circuits.Biomolecules202642352256PubTator, text miningPubMed
The orexinergic system in the retina: Expression and physiological impact-A review of the literature.Front Neuroendocrinol202642150720PubTator, text miningPubMed

1 to 10 of 869

See all 869 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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