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Gene · 32

ACACB: acetyl-CoA carboxylase beta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACACB: acetyl-CoA carboxylase beta. Genes, record 32. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/32

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Gene

Symbol
ACACB
HGNC
Name
acetyl-CoA carboxylase beta
HGNC
NCBI Gene ID
32
NCBI Gene
HGNC ID
HGNC:85
HGNC
Ensembl
ENSG00000076555
NCBI Gene
Aliases
ACACbeta, ACC-beta, ACC2, ACCB, ACCbeta, HACC275
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00763Acetyl-CoA carboxylase 22,45811Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436008O00763Espacenet
JP 2026004568 A2026-01-1436009O00763Espacenet
EP 4650780 A22025-11-196611O00763Espacenet
EP 4640849 A22025-10-29948O00763Espacenet
EP 4641201 A22025-10-296357O00763Espacenet
EP 4641203 A22025-10-29198O00763Espacenet
JP 2025147176 A2025-10-0697O00763Espacenet
JP 2025147176 A2025-10-0698O00763Espacenet
JP 2025529142 A2025-09-045351O00763Espacenet
US 12371689 B22025-07-295351O00763Espacenet

1 to 10 of 45

See all 45 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CLESACOSTATCHEMBL4567446Acetyl-CoA carboxylase inhibitorINHIBITORChEMBL
FIRSOCOSTATCHEMBL3407547Acetyl-CoA carboxylase negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
OLUMACOSTAT GLASARETILCHEMBL3989947Acetyl-CoA carboxylase inhibitorINHIBITORChEMBL
PF-05175157CHEMBL3359265Acetyl-CoA carboxylase inhibitorINHIBITORChEMBL

Trials19

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04971785FIRSOCOSTATPHASE22025-11-26ClinicalTrials.gov
NCT04399538CLESACOSTATPHASE22023-04-13ClinicalTrials.gov
NCT04395950CLESACOSTATPHASE1ClinicalTrials.gov
NCT04321031CLESACOSTATPHASE22025-03-21ClinicalTrials.gov
NCT03987074FIRSOCOSTATPHASE22021-07-15ClinicalTrials.gov
NCT03776175CLESACOSTATPHASE22020-09-23ClinicalTrials.gov
NCT03449446FIRSOCOSTATPHASE22020-12-03ClinicalTrials.gov
NCT03248882CLESACOSTATPHASE22020-03-10ClinicalTrials.gov
NCT03127956OLUMACOSTAT GLASARETILPHASE32019-02-05ClinicalTrials.gov
NCT03073486OLUMACOSTAT GLASARETILPHASE32019-02-05ClinicalTrials.gov

1 to 10 of 19

See all 19 trials

NIH grants914

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACACB papersNewest fiscal year
P30CA016672Cancer Center Support Grant82025
P30DK063491Diabetes Research Center (DRC)42025
R01CA090764PI3K/PTEN/Akt signaling and the genesis of cancer42025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes32025
P30CA010815Consolidated Basic Cancer Research Program32025
P30DK045735Yale Diabetes Research Center32025
R01DK089312Mechanisms of lipid-induced bioenergetic stress in muscle32025
R01DK117850Systems Genetics Dissection of Non-alcoholic Steatohepatitis32025
P30CA012197Cancer Center Support Grant22025
P30CA014195Cancer Center Support Grant (CCSG)22025

1 to 10 of 914Source NIH's project files

See all 914 nih grants

Papers1,556

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Oxeiptosis-Associated Molecular Subtyping and Immune Microenvironment Heterogeneity in Osteoarthritis.Biomedicines202642792820PubTator, text miningPubMed
Identification of functional genes and immune cell infiltration analysis in liposarcoma.PLoS One202642726806PubTator, text miningPubMed
An Integrated Analysis of Manganese Metabolism-Related Genes and Their Association With Biomarkers, Immune Infiltration, and Clinical Subtypes in Alzheimer's Disease.Genes Brain Behav202642723412PubTator, text miningPubMed
Interpretable Prediction of Ligand-Protein Binding without Protein Structural Information.J Med Chem202642679162PubTator, text miningPubMed
A Deep Learning Framework for the Discovery of Natural-Product Candidate Binders of Acetyl-CoA Carboxylase 2 (ACC2) with Potential Relevance to Cardiometabolic Lipid Metabolism.Pharmaceuticals (Basel)202642515804PubTator, text miningPubMed
Hyperhomocysteinemia promotes lipid deposition in skeletal muscle.Front Neurol202642383022PubTator, text miningPubMed
Exploring the Toxicological Impact and Mechanisms of DEHP Exposure on Prostate Cancer Through Network Toxicology and Machine Learning Algorithms.Curr Med Chem202642304923PubTator, text miningPubMed
Shared Plant-human Biology: Herbicide Effects and New Biomarkers Perspectives.Curr Environ Health Rep202641925771PubTator, text miningPubMed
Metabolomic Profiling of Tyrosine Kinase Inhibitor-Induced Endothelial Dysfunction and Cardiovascular Toxicity.Metabolites202641893349PubTator, text miningPubMed
Integrated transcriptomic and metabolomic analysis reveals potential candidate genes and regulatory pathways associated with egg weight in geese.Poult Sci202641887172PubTator, text miningPubMed

1 to 10 of 1,556

See all 1,556 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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