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Gene · 3242

HPD: 4-hydroxyphenylpyruvate dioxygenase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HPD: 4-hydroxyphenylpyruvate dioxygenase. Genes, record 3242. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3242

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Gene

Symbol
HPD
HGNC
Name
4-hydroxyphenylpyruvate dioxygenase
HGNC
NCBI Gene ID
3242
NCBI Gene
HGNC ID
HGNC:5147
HGNC
Ensembl
ENSG00000158104
NCBI Gene
Aliases
4-HPPD, 4HPPD, GLOD3, HPPD, HPPDASE, PPD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P327544-hydroxyphenylpyruvate dioxygenase3934Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12606850 B22026-04-2192P32754Espacenet
EP 4650780 A22025-11-193380P32754Espacenet
JP 2025169942 A2025-11-14769P32754Espacenet
EP 4641201 A22025-10-292957P32754Espacenet
JP 2025517969 A2025-06-122957P32754Espacenet
JP 2025517970 A2025-06-123380P32754Espacenet
JP 2025062604 A2025-04-14328P32754Espacenet
US 12234495 B22025-02-2592P32754Espacenet
US 11920177 B22024-03-0592P32754Espacenet
JP 2023111889 A2023-08-106P32754Espacenet

1 to 10 of 28

See all 28 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
NITISINONECHEMBL13374-hydroxyphenylpyruvate dioxygenase inhibitorINHIBITOR

Source ChEMBL

Trials7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01916382NITISINONEPHASE3ClinicalTrials.gov
NCT01838655NITISINONEPHASE1/PHASE22017-11-17ClinicalTrials.gov
NCT01828463NITISINONEPHASE2ClinicalTrials.gov
NCT01390077NITISINONEPHASE2/PHASE32021-04-22ClinicalTrials.gov
NCT00107783NITISINONEPHASE22011-01-19ClinicalTrials.gov
NCT00031161NITISINONEClinicalTrials.gov
NCT00004443NITISINONEClinicalTrials.gov

NIH grants469

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHPD papersNewest fiscal year
ZIAAI001065India International Center for Excellence in Research52025
P20GM103499South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE)42025
R01HL132840Genetic Repair of Familial Hypercholesterolemia32025
D43TW009127Ethiopia-Emory TB Research Training Program22025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant22025
P30DK056338Texas Medical Center Digestive Diseases Center22025
T32HL092332Training In Cell and Gene Therapy22025
ZIAAI000197Immunoregulation /Immune Recognition In Filarial/Nonfilarial Parasitic Infection22025
ZIAHD008814Mammalian iron-sulfur cluster biogenesis22025
ZIAHG000215Human Biochemical Genetics22025

1 to 10 of 469Source NIH's project files

See all 469 nih grants

Papers1,367

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Plasma and urinary NMR metabolic profiling of the phenylalanine-tyrosine pathway in nitisinone-treated alkaptonuria: comparison of two dosing regimens and identification of a candidate pharmacodynamic biomarker.
Mol Genet Metab202642685651PubTator, text miningPubMed
Azospirillum caeni sp. nov., a mesotrione-resistant and nitrogen-fixing bacterium isolated from an activated sludge.Int J Syst Evol Microbiol202642446519PubTator, text miningPubMed
HPD is a copper-binding protein that interacts with DLAT to promote colorectal cancer cuproptosis under copper stress.Cell Rep202642391001PubTator, text miningPubMed
Disease associated missense substitutions disrupt structural stability and catalytic function of 4-hydroxyphenylpyruvate dioxygenase.J Biol Chem202642140431PubTator, text miningPubMed
LC-HRMS metabolomic profiling of Anisosciadium lanatum and Its antioxidant and phytotoxic potential.Sci Rep202642086633PubTator, text miningPubMed
Integrated multi-omics data and machine learning approaches to decipher the molecular network and gene signatures of renal cell carcinoma induced by aristolochic acid.Biochem Biophys Res Commun202642033937PubTator, text miningPubMed
A rare coexistence: tyrosinemia type III and Wolff-Parkinson-White syndrome.J Pediatr Endocrinol Metab202641956115PubTator, text miningPubMed
Shared Plant-human Biology: Herbicide Effects and New Biomarkers Perspectives.Curr Environ Health Rep202641925771PubTator, text miningPubMed
Spotting a unicorn: spatial transcriptome analysis of the eyelid reveals gene regulatory networks enriched in Moll glands.Brief Bioinform202641903186PubTator, text miningPubMed
Evaluation of allelopathic potentialities of an invasive taxon, Mesosphaerum suaveolens (L.) Kuntze, and bio-assay-guided identification of the involved allelochemicals.Sci Rep202641888537PubTator, text miningPubMed

1 to 10 of 1,367

See all 1,367 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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