Gene · 3242
HPD: 4-hydroxyphenylpyruvate dioxygenase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HPD: 4-hydroxyphenylpyruvate dioxygenase. Genes, record 3242. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3242
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P32754 | 4-hydroxyphenylpyruvate dioxygenase | 393 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents28
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12606850 B2 | 2026-04-21 | 92 | P32754 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3380 | P32754 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 769 | P32754 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2957 | P32754 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2957 | P32754 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3380 | P32754 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 328 | P32754 | Espacenet |
| US 12234495 B2 | 2025-02-25 | 92 | P32754 | Espacenet |
| US 11920177 B2 | 2024-03-05 | 92 | P32754 | Espacenet |
| JP 2023111889 A | 2023-08-10 | 6 | P32754 | Espacenet |
1 to 10 of 28
See all 28 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| NITISINONE | CHEMBL1337 | 4-hydroxyphenylpyruvate dioxygenase inhibitor | INHIBITOR |
Source ChEMBL
Trials7
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT01916382 | NITISINONE | PHASE3 | ClinicalTrials.gov | |
| NCT01838655 | NITISINONE | PHASE1/PHASE2 | 2017-11-17 | ClinicalTrials.gov |
| NCT01828463 | NITISINONE | PHASE2 | ClinicalTrials.gov | |
| NCT01390077 | NITISINONE | PHASE2/PHASE3 | 2021-04-22 | ClinicalTrials.gov |
| NCT00107783 | NITISINONE | PHASE2 | 2011-01-19 | ClinicalTrials.gov |
| NCT00031161 | NITISINONE | ClinicalTrials.gov | ||
| NCT00004443 | NITISINONE | ClinicalTrials.gov |
NIH grants469
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HPD papers | Newest fiscal year |
|---|---|---|---|
| ZIAAI001065 | India International Center for Excellence in Research | 5 | 2025 |
| P20GM103499 | South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE) | 4 | 2025 |
| R01HL132840 | Genetic Repair of Familial Hypercholesterolemia | 3 | 2025 |
| D43TW009127 | Ethiopia-Emory TB Research Training Program | 2 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 2 | 2025 |
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 2 | 2025 |
| T32HL092332 | Training In Cell and Gene Therapy | 2 | 2025 |
| ZIAAI000197 | Immunoregulation /Immune Recognition In Filarial/Nonfilarial Parasitic Infection | 2 | 2025 |
| ZIAHD008814 | Mammalian iron-sulfur cluster biogenesis | 2 | 2025 |
| ZIAHG000215 | Human Biochemical Genetics | 2 | 2025 |
1 to 10 of 469Source NIH's project files
See all 469 nih grantsPapers1,367
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
Plasma and urinary NMR metabolic profiling of the phenylalanine-tyrosine pathway in nitisinone-treated alkaptonuria: comparison of two dosing regimens and identification of a candidate pharmacodynamic biomarker. | Mol Genet Metab | 2026 | 42685651 | PubTator, text mining | PubMed |
| Azospirillum caeni sp. nov., a mesotrione-resistant and nitrogen-fixing bacterium isolated from an activated sludge. | Int J Syst Evol Microbiol | 2026 | 42446519 | PubTator, text mining | PubMed |
| HPD is a copper-binding protein that interacts with DLAT to promote colorectal cancer cuproptosis under copper stress. | Cell Rep | 2026 | 42391001 | PubTator, text mining | PubMed |
| Disease associated missense substitutions disrupt structural stability and catalytic function of 4-hydroxyphenylpyruvate dioxygenase. | J Biol Chem | 2026 | 42140431 | PubTator, text mining | PubMed |
| LC-HRMS metabolomic profiling of Anisosciadium lanatum and Its antioxidant and phytotoxic potential. | Sci Rep | 2026 | 42086633 | PubTator, text mining | PubMed |
| Integrated multi-omics data and machine learning approaches to decipher the molecular network and gene signatures of renal cell carcinoma induced by aristolochic acid. | Biochem Biophys Res Commun | 2026 | 42033937 | PubTator, text mining | PubMed |
| A rare coexistence: tyrosinemia type III and Wolff-Parkinson-White syndrome. | J Pediatr Endocrinol Metab | 2026 | 41956115 | PubTator, text mining | PubMed |
| Shared Plant-human Biology: Herbicide Effects and New Biomarkers Perspectives. | Curr Environ Health Rep | 2026 | 41925771 | PubTator, text mining | PubMed |
| Spotting a unicorn: spatial transcriptome analysis of the eyelid reveals gene regulatory networks enriched in Moll glands. | Brief Bioinform | 2026 | 41903186 | PubTator, text mining | PubMed |
| Evaluation of allelopathic potentialities of an invasive taxon, Mesosphaerum suaveolens (L.) Kuntze, and bio-assay-guided identification of the involved allelochemicals. | Sci Rep | 2026 | 41888537 | PubTator, text mining | PubMed |
1 to 10 of 1,367
See all 1,367 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3242
GET https://conductscience.org/api/genes/v1/3242/patents?page=2