Gene · 326
AIRE: autoimmune regulator
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. AIRE: autoimmune regulator. Genes, record 326. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/326
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43918 | Autoimmune regulator | 545 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents29
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 38531 | O43918 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 434 | O43918 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3056 | O43918 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 14734 | O43918 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 434 | O43918 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3056 | O43918 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 7945 | O43918 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 14734 | O43918 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 14734 | O43918 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 14573 | O43918 | Espacenet |
1 to 10 of 29
See all 29 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,694
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | AIRE papers | Newest fiscal year |
|---|---|---|---|
| ZIAAI001175 | Immunopathogenesis of Fungal Infections | 23 | 2025 |
| R01DK060027 | Aire, a zinc-finger protein that controls autoimmunity | 21 | 2025 |
| UL1TR001866 | Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success | 18 | 2025 |
| ZIAAI001222 | Characterization of the cellular and molecular bases of inborn errors of immunity | 17 | 2025 |
| R01AI127564 | Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis | 13 | 2025 |
| R01AI088204 | The molecular mechanism of Aire | 12 | 2025 |
| R01AI163029 | Inborn errors of immunity in patients with life-threatening COVID-19 | 12 | 2025 |
| R37AI097457 | Thymic medullary epithelial cell turnover and control of immune tolerance | 11 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| ZIAAI000647 | Genes And Gene Products As Immunoadjuvants | 10 | 2025 |
1 to 10 of 1,694Source NIH's project files
See all 1,694 nih grantsPapers2,741
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Aire is a cell-intrinsic regulator of natural IgM-secreting cells. | Immunity | 2026 | 42815461 | PubTator, text mining | PubMed |
| Vitamin D signaling in thymic development and longevity. | Front Nutr | 2026 | 42812403 | PubTator, text mining | PubMed |
| Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED): Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, and Management. | Endocr Metab Immune Disord Drug Targets | 2026 | 42786839 | PubTator, text mining | PubMed |
| Genetic Heterogeneity of Inborn Errors of Immunity Revealed by Whole-Genome Sequencing: Insights from a Russian Patient Cohort. | Int J Mol Sci | 2026 | 42737820 | PubTator, text mining | PubMed |
| NETs mediate neuropathic pain in PSS-PN by participating in inflammatory injury to the vasa nervorum. | Clin Rheumatol | 2026 | 42696213 | PubTator, text mining | PubMed |
| Cancer Immunotherapy Using AIRE Conditioning of the Tumor Epitopeome. | Cancer Immunol Res | 2026 | 42644627 | PubTator, text mining | PubMed |
| Genetic context shapes interpretation of AIRE and Notch4 in alopecia areata. | JID Innov | 2026 | 42633099 | PubTator, text mining | PubMed |
| Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females. | Elife | 2026 | 42623268 | PubTator, text mining | PubMed |
| Multi-omics-guided targeting of the CD14-NF-κB axis with PGA1-loaded liposomes restores CD14hi TSPCs function and promotes tendon-bone healing in diabetes. | Mater Today Bio | 2026 | 42603967 | PubTator, text mining | PubMed |
| Alopecia Areata Associated With a Dominant AIRE Variant. | J Dermatol | 2026 | 42587409 | PubTator, text mining | PubMed |
1 to 10 of 2,741
See all 2,741 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/326
GET https://conductscience.org/api/genes/v1/326/patents?page=2