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Gene · 326

AIRE: autoimmune regulator

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AIRE: autoimmune regulator. Genes, record 326. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/326

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Gene

Symbol
AIRE
HGNC
Name
autoimmune regulator
HGNC
NCBI Gene ID
326
NCBI Gene
HGNC ID
HGNC:360
HGNC
Ensembl
ENSG00000160224
NCBI Gene
Aliases
AIRE1, APECED, APS1, APSI, PGA1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43918Autoimmune regulator5454Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1438531O43918Espacenet
EP 4640849 A22025-10-29434O43918Espacenet
EP 4641201 A22025-10-293056O43918Espacenet
JP 2025147176 A2025-10-0614734O43918Espacenet
JP 2025519096 A2025-06-24434O43918Espacenet
JP 2025517969 A2025-06-123056O43918Espacenet
JP 2025062604 A2025-04-147945O43918Espacenet
JP 2025028160 A2025-02-2814734O43918Espacenet
KR 1020250010750 A2025-01-2114734O43918Espacenet
JP 2024109657 A2024-08-1414573O43918Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,694

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAIRE papersNewest fiscal year
ZIAAI001175Immunopathogenesis of Fungal Infections232025
R01DK060027Aire, a zinc-finger protein that controls autoimmunity212025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success182025
ZIAAI001222Characterization of the cellular and molecular bases of inborn errors of immunity172025
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis132025
R01AI088204The molecular mechanism of Aire122025
R01AI163029Inborn errors of immunity in patients with life-threatening COVID-19122025
R37AI097457Thymic medullary epithelial cell turnover and control of immune tolerance112025
P30CA008748Cancer Center Support Grant102025
ZIAAI000647Genes And Gene Products As Immunoadjuvants102025

1 to 10 of 1,694Source NIH's project files

See all 1,694 nih grants

Papers2,741

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Aire is a cell-intrinsic regulator of natural IgM-secreting cells.Immunity202642815461PubTator, text miningPubMed
Vitamin D signaling in thymic development and longevity.Front Nutr202642812403PubTator, text miningPubMed
Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED): Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, and Management.Endocr Metab Immune Disord Drug Targets202642786839PubTator, text miningPubMed
Genetic Heterogeneity of Inborn Errors of Immunity Revealed by Whole-Genome Sequencing: Insights from a Russian Patient Cohort.Int J Mol Sci202642737820PubTator, text miningPubMed
NETs mediate neuropathic pain in PSS-PN by participating in inflammatory injury to the vasa nervorum.Clin Rheumatol202642696213PubTator, text miningPubMed
Cancer Immunotherapy Using AIRE Conditioning of the Tumor Epitopeome.Cancer Immunol Res202642644627PubTator, text miningPubMed
Genetic context shapes interpretation of AIRE and Notch4 in alopecia areata.JID Innov202642633099PubTator, text miningPubMed
Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females.Elife202642623268PubTator, text miningPubMed
Multi-omics-guided targeting of the CD14-NF-κB axis with PGA1-loaded liposomes restores CD14hi TSPCs function and promotes tendon-bone healing in diabetes.Mater Today Bio202642603967PubTator, text miningPubMed
Alopecia Areata Associated With a Dominant AIRE Variant.J Dermatol202642587409PubTator, text miningPubMed

1 to 10 of 2,741

See all 2,741 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/326

GET https://conductscience.org/api/genes/v1/326/patents?page=2