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Gene · 3274

HRH2: histamine receptor H2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HRH2: histamine receptor H2. Genes, record 3274. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3274

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Gene

Symbol
HRH2
HGNC
Name
histamine receptor H2
HGNC
NCBI Gene ID
3274
NCBI Gene
HGNC ID
HGNC:5183
HGNC
Ensembl
ENSG00000113749
NCBI Gene
Aliases
H2R, HH2R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P25021Histamine H2 receptor3596Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449118P25021Espacenet
EP 4641201 A22025-10-29576P25021Espacenet
EP 4641202 A22025-10-2934P25021Espacenet
JP 2025529142 A2025-09-041983P25021Espacenet
US 12371689 B22025-07-291983P25021Espacenet
JP 2025517969 A2025-06-12576P25021Espacenet
JP 2025032204 A2025-03-1129664P25021Espacenet
KR 1020250017231 A2025-02-0434P25021Espacenet
EP 4461818 A22024-11-1329664P25021Espacenet
JP 2023058610 A2023-04-2529664P25021Espacenet

1 to 10 of 38

See all 38 patents

Drugs15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BETAZOLECHEMBL1201323Histamine H2 receptor agonistAGONISTChEMBL
BETAZOLE HYDROCHLORIDECHEMBL1200949Histamine H2 receptor agonistAGONISTChEMBL
CIMETIDINECHEMBL30Histamine H2 receptor antagonistANTAGONISTChEMBL
CIMETIDINE HYDROCHLORIDECHEMBL1201051Histamine H2 receptor antagonistANTAGONISTChEMBL
EBROTIDINECHEMBL1742471Histamine H2 receptor antagonistANTAGONISTChEMBL
FAMOTIDINECHEMBL902Histamine H2 receptor antagonistANTAGONISTChEMBL
LAFUTIDINECHEMBL1742461Histamine H2 receptor antagonistANTAGONISTChEMBL
METHANTHELINECHEMBL1201264Histamine H2 receptor antagonistANTAGONISTChEMBL
METHANTHELINE BROMIDECHEMBL1200988Histamine H2 receptor antagonistANTAGONISTChEMBL
NIZATIDINECHEMBL3183075Histamine H2 receptor antagonistANTAGONISTChEMBL

1 to 10 of 15

See all 15 drugs

Trials52

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06313307FAMOTIDINEClinicalTrials.gov
NCT06241183FAMOTIDINEPHASE4ClinicalTrials.gov
NCT06207305FAMOTIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT05946551FAMOTIDINEPHASE32025-07-17ClinicalTrials.gov
NCT05163756FAMOTIDINEPHASE3ClinicalTrials.gov
NCT05122208FAMOTIDINEClinicalTrials.gov
NCT05085574FAMOTIDINEPHASE2ClinicalTrials.gov
NCT05084521FAMOTIDINEPHASE2/PHASE3ClinicalTrials.gov
NCT05077332FAMOTIDINEPHASE2ClinicalTrials.gov
NCT05043350FAMOTIDINEPHASE2/PHASE3ClinicalTrials.gov

1 to 10 of 52

See all 52 trials

NIH grants730

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHRH2 papersNewest fiscal year
ZIADK053200Diagnosis, Natural History, Management, tumor biology of Gastrinomas/PETs/Neuroendocrine tumors92025
P30DK056338Texas Medical Center Digestive Diseases Center82025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease32025
T32DK007664Research Training in Pediatrics Gastroenterolgy32025
KL2TR002317Institutional Career Development Core22025
P30CA021765Cancer Center Support Grant (CCSG)22025
R01GM132672The ion channel TRPA1 is required for suppression of inflammation22025
R25MH077823Research Education for Future Physician-Scientists in Child Psychiatry22025
R35GM118182Molecular basis of bioelectronic medicine22025
R35GM124871Olfactory receptor-based sensors for biomedical applications22025

1 to 10 of 730Source NIH's project files

See all 730 nih grants

Papers2,217

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cross-Talk Between Histamine H2 Receptor and Glucocorticoid Receptor: Potential Implications in Acute Myeloid Leukemia Treatment.Pharmacol Res Perspect202642736631PubTator, text miningPubMed
Elevated Histamine Receptor 2 and Toll-Like Receptor 7 Expression in Rheumatoid Arthritis: Insights Into Inflammatory Mechanisms and Potential Therapeutic Strategies.Int J Rheum Dis202642578414PubTator, text miningPubMed
Dissociation and tautomerism of some amino-, nitro-, and aminonitrofluoresceins in DMSO: Either resolution or inversion of the Ka1 and Ka2 values.Spectrochim Acta A Mol Biomol Spectrosc202642526097PubTator, text miningPubMed
Myeloid Cell-Derived Thrombospondin-1 Mediates Anti-Metastatic Effects of Histamine Dihydrochloride in B16 Melanoma.Immunotargets Ther202642281617PubTator, text miningPubMed
Investigating the Impact of Bisphenol A on Gastric Cancer Through Network Toxicology and Molecular Docking.Int J Toxicol202642134865PubTator, text miningPubMed
Quantitative deciphering of mammalian histamine receptors through mathematical genomics.Biochem Biophys Res Commun202641946080PubTator, text miningPubMed
Cytotoxic effect of famotidine in breast adenocarcinoma cells line.North Clin Istanb202641940059PubTator, text miningPubMed
Neurotransmitter Systems in Alzheimer's Disease.Curr Issues Mol Biol202641899485PubTator, text miningPubMed
Molecular Markers Distinguishing Early-Stage Mycosis Fungoides From Atopic Dermatitis Skin Lesions.Exp Dermatol202641888970PubTator, text miningPubMed
Harnessing metabolomics and proteomics in a clinical trial for pulmonary arterial hypertension: insights from post-hoc analysis of the REHAB-PH trial.EBioMedicine202641849831PubTator, text miningPubMed

1 to 10 of 2,217

See all 2,217 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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