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Gene · 3283

HSD3B1: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HSD3B1: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1. Genes, record 3283. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3283

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Gene

Symbol
HSD3B1
HGNC
Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HGNC
NCBI Gene ID
3283
NCBI Gene
HGNC ID
HGNC:5217
HGNC
Ensembl
ENSG00000203857
NCBI Gene
Aliases
3BETAHSD, HSD3B, HSDB3, HSDB3A, SDR11E1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P140603 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 13730Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4795035 A12026-08-262P14060Espacenet
JP 2026004568 A2026-01-1449522P14060Espacenet
JP 2026004568 A2026-01-1449523P14060Espacenet
JP 2025529142 A2025-09-041995P14060Espacenet
US 12371689 B22025-07-291995P14060Espacenet
JP 2025521593 A2025-07-102P14060Espacenet
US 11446398 B22022-09-2039220P14060Espacenet
US 11446398 B22022-09-2039221P14060Espacenet
JP 2022524081 A2022-04-27142191P14060Espacenet
JP 2022524081 A2022-04-27142192P14060Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,291

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHSD3B1 papersNewest fiscal year
R01CA172382Elucidating a novel molecular biomarker for castration-resistant prostate cancer382025
P30ES013508Center of Excellence in Environmental Toxicology272025
R01DK043140Mechanisms Leading to Adrenal Zonation212025
P50CA097186The Pacific Northwest Prostate Cancer SPORE192025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer162025
T32ES007326Interdisciplinary Research Training Program in Environmental Health and Toxicology122025
P30CA008748Cancer Center Support Grant112025
R01CA261995CYP17A1-independent androgen synthesis and prostate cancer resistance to next-generation hormonal therapy112025
R01GM086596Activation of androgen biosynthesis and drug metabolism by cytochrome b592025
P30CA006973Regional Oncology Research Center72025

1 to 10 of 1,291Source NIH's project files

See all 1,291 nih grants

Papers3,575

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Dietary vitamin C improves reproductive performance by increasing antioxidant capacity, steroid hormone concentration and expression of genes involved in steroid hormone synthesis in Yangzhou geese.Br Poult Sci202642813264PubTator, text miningPubMed
MiR-130b-3p regulates steroidogenesis-related markers, cell viability, inflammation, oxidative stress, and pyroptosis-associated responses by targeting PPARG in LPS-exposed goat granulosa cells.Anim Reprod Sci202642790158PubTator, text miningPubMed
Integrative Genetic and Bioinformatic Analysis of Androgen Pathway Gene Polymorphisms, Testosterone, and PSA Levels in Prostate Cancer.Genet Test Mol Biomarkers202642765541PubTator, text miningPubMed
Molecular Mechanisms of Endocrine-Disrupting Chemicals and Emerging-Pollutant Toxicity in Human Reproduction: From Xenobiotic Exposure to Fertility Impairment and Reproductive Carcinogenesis.Int J Mol Sci202642737662PubTator, text miningPubMed
Association of organophosphate flame retardant exposure with female infertility: Cross-sectional and mechanistic evidence.Ecotoxicol Environ Saf202642710202PubTator, text miningPubMed
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate ovarian aging by inhibiting ferroptosis.Reproduction202642644839PubTator, text miningPubMed
APUC-6 Genes as a Potential Prognostic and Predictive Biomarker in the CHAARTED Prostate Cancer Trial.JCO Precis Oncol202642628007PubTator, text miningPubMed
Herbicides as Isoform-Selective Inhibitors of Human 3β-HSD1 and Rat 3β-HSD4: Structure-Activity Relationships and Implications for Progesterone Biosynthesis and Recurrent Pregnancy Loss.J Agric Food Chem202642616451PubTator, text miningPubMed
Disruption of progesterone synthesis by PBDEs: Potent inhibition of human and rat placental 3β-hydroxysteroid dehydrogenase by the metabolite 4-Bromodiphenyl ether.Toxicol Appl Pharmacol202642571812PubTator, text miningPubMed
Effects and mechanisms of NMB knockdown on cell proliferation, apoptosis and steroidogenesis in porcine ovarian granulosa cells.Theriogenology202642570474PubTator, text miningPubMed

1 to 10 of 3,575

See all 3,575 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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