Gene · 3283
HSD3B1: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HSD3B1: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1. Genes, record 3283. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3283
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P14060 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | 373 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents40
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4795035 A1 | 2026-08-26 | 2 | P14060 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 49522 | P14060 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 49523 | P14060 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1995 | P14060 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1995 | P14060 | Espacenet |
| JP 2025521593 A | 2025-07-10 | 2 | P14060 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 39220 | P14060 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 39221 | P14060 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 142191 | P14060 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 142192 | P14060 | Espacenet |
1 to 10 of 40
See all 40 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,291
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HSD3B1 papers | Newest fiscal year |
|---|---|---|---|
| R01CA172382 | Elucidating a novel molecular biomarker for castration-resistant prostate cancer | 38 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 27 | 2025 |
| R01DK043140 | Mechanisms Leading to Adrenal Zonation | 21 | 2025 |
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 19 | 2025 |
| P01CA163227 | Androgen Receptor Action in Castration Resistant Prostate Cancer | 16 | 2025 |
| T32ES007326 | Interdisciplinary Research Training Program in Environmental Health and Toxicology | 12 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 11 | 2025 |
| R01CA261995 | CYP17A1-independent androgen synthesis and prostate cancer resistance to next-generation hormonal therapy | 11 | 2025 |
| R01GM086596 | Activation of androgen biosynthesis and drug metabolism by cytochrome b5 | 9 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 7 | 2025 |
1 to 10 of 1,291Source NIH's project files
See all 1,291 nih grantsPapers3,575
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Dietary vitamin C improves reproductive performance by increasing antioxidant capacity, steroid hormone concentration and expression of genes involved in steroid hormone synthesis in Yangzhou geese. | Br Poult Sci | 2026 | 42813264 | PubTator, text mining | PubMed |
| MiR-130b-3p regulates steroidogenesis-related markers, cell viability, inflammation, oxidative stress, and pyroptosis-associated responses by targeting PPARG in LPS-exposed goat granulosa cells. | Anim Reprod Sci | 2026 | 42790158 | PubTator, text mining | PubMed |
| Integrative Genetic and Bioinformatic Analysis of Androgen Pathway Gene Polymorphisms, Testosterone, and PSA Levels in Prostate Cancer. | Genet Test Mol Biomarkers | 2026 | 42765541 | PubTator, text mining | PubMed |
| Molecular Mechanisms of Endocrine-Disrupting Chemicals and Emerging-Pollutant Toxicity in Human Reproduction: From Xenobiotic Exposure to Fertility Impairment and Reproductive Carcinogenesis. | Int J Mol Sci | 2026 | 42737662 | PubTator, text mining | PubMed |
| Association of organophosphate flame retardant exposure with female infertility: Cross-sectional and mechanistic evidence. | Ecotoxicol Environ Saf | 2026 | 42710202 | PubTator, text mining | PubMed |
| Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate ovarian aging by inhibiting ferroptosis. | Reproduction | 2026 | 42644839 | PubTator, text mining | PubMed |
| APUC-6 Genes as a Potential Prognostic and Predictive Biomarker in the CHAARTED Prostate Cancer Trial. | JCO Precis Oncol | 2026 | 42628007 | PubTator, text mining | PubMed |
| Herbicides as Isoform-Selective Inhibitors of Human 3β-HSD1 and Rat 3β-HSD4: Structure-Activity Relationships and Implications for Progesterone Biosynthesis and Recurrent Pregnancy Loss. | J Agric Food Chem | 2026 | 42616451 | PubTator, text mining | PubMed |
| Disruption of progesterone synthesis by PBDEs: Potent inhibition of human and rat placental 3β-hydroxysteroid dehydrogenase by the metabolite 4-Bromodiphenyl ether. | Toxicol Appl Pharmacol | 2026 | 42571812 | PubTator, text mining | PubMed |
| Effects and mechanisms of NMB knockdown on cell proliferation, apoptosis and steroidogenesis in porcine ovarian granulosa cells. | Theriogenology | 2026 | 42570474 | PubTator, text mining | PubMed |
1 to 10 of 3,575
See all 3,575 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3283
GET https://conductscience.org/api/genes/v1/3283/patents?page=2