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HSD3B1: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
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Gene · 3283

Papers3,575

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 3,575

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TitleJournalYearPMIDFound bySource
Dietary vitamin C improves reproductive performance by increasing antioxidant capacity, steroid hormone concentration and expression of genes involved in steroid hormone synthesis in Yangzhou geese.Br Poult Sci202642813264PubTator, text miningPubMed
MiR-130b-3p regulates steroidogenesis-related markers, cell viability, inflammation, oxidative stress, and pyroptosis-associated responses by targeting PPARG in LPS-exposed goat granulosa cells.Anim Reprod Sci202642790158PubTator, text miningPubMed
Integrative Genetic and Bioinformatic Analysis of Androgen Pathway Gene Polymorphisms, Testosterone, and PSA Levels in Prostate Cancer.Genet Test Mol Biomarkers202642765541PubTator, text miningPubMed
Molecular Mechanisms of Endocrine-Disrupting Chemicals and Emerging-Pollutant Toxicity in Human Reproduction: From Xenobiotic Exposure to Fertility Impairment and Reproductive Carcinogenesis.Int J Mol Sci202642737662PubTator, text miningPubMed
Association of organophosphate flame retardant exposure with female infertility: Cross-sectional and mechanistic evidence.Ecotoxicol Environ Saf202642710202PubTator, text miningPubMed
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate ovarian aging by inhibiting ferroptosis.Reproduction202642644839PubTator, text miningPubMed
APUC-6 Genes as a Potential Prognostic and Predictive Biomarker in the CHAARTED Prostate Cancer Trial.JCO Precis Oncol202642628007PubTator, text miningPubMed
Herbicides as Isoform-Selective Inhibitors of Human 3β-HSD1 and Rat 3β-HSD4: Structure-Activity Relationships and Implications for Progesterone Biosynthesis and Recurrent Pregnancy Loss.J Agric Food Chem202642616451PubTator, text miningPubMed
Disruption of progesterone synthesis by PBDEs: Potent inhibition of human and rat placental 3β-hydroxysteroid dehydrogenase by the metabolite 4-Bromodiphenyl ether.Toxicol Appl Pharmacol202642571812PubTator, text miningPubMed
Effects and mechanisms of NMB knockdown on cell proliferation, apoptosis and steroidogenesis in porcine ovarian granulosa cells.Theriogenology202642570474PubTator, text miningPubMed
Insights into the inhibitory mechanisms of alkyl phosphate esters on 3β-hydroxysteroid dehydrogenases: Implications for placental reproductive toxicity.Bioorg Chem202642561558PubTator, text miningPubMed
3beta-HSD1-mediated steroid back-conversion maintains androgen signaling in prostate cancer.Mol Cancer Res202642518214PubTator, text miningPubMed
Late-follicular androgen and estrogen rise associated with clinical pregnancy in IVF/ICSI with granulosa cell studies.Reprod Fertil202642455811PubTator, text miningPubMed
Benzalkonium chloride disrupts human placental progesterone synthesis via locking NAD+ pocket in 3β-Hydroxysteroid dehydrogenase 1 and rat homolog: docking evidence and 3D-QSAR, and experiment risk assessment.
Bioorg Chem202642398392PubTator, text miningPubMed
Species-specific inhibition of human and rat gonadal 3β-hydroxysteroid dehydrogenases by emerging organophosphate esters: A multiscale approach combining in vitro assays and computational modeling.Ecotoxicol Environ Saf202642364630PubTator, text miningPubMed
Transcriptomic Profile of Genes Regulating Cellular Response to Extra- and Intracellular Stimuli in Porcine Ovarian Granulosa Cells During In Vitro Cultivation.Int J Mol Sci202642353161PubTator, text miningPubMed
HSD3B1 links ileal steroid metabolism to bile acid regulation in patients with prostate cancer.J Clin Invest202642294886PubTator, text miningPubMed
The elevated clock genes involved in regulating the hormone secretion and follicular development during the laying period of geese.Anim Reprod Sci202642287886PubTator, text miningPubMed
Post-translational regulation of steroidogenesis and its clinical relevance in hormone responsive cancers.Semin Oncol202642275676PubTator, text miningPubMed
Intracrine androgen metabolism in the meibomian gland: regulation, circadian control, and implications in dry eye disease.Endocr J202642219372PubTator, text miningPubMed

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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