Gene · 3290
HSD11B1: hydroxysteroid 11-beta dehydrogenase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HSD11B1: hydroxysteroid 11-beta dehydrogenase 1. Genes, record 3290. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3290
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P28845 | 11-beta-hydroxysteroid dehydrogenase 1 | 292 | 42 | Ensembl, GeneID, HGNC |
Source UniProt
Patents58
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 49539 | P28845 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 49540 | P28845 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 49541 | P28845 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8151 | P28845 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8151 | P28845 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 39271 | P28845 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 39272 | P28845 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3307 | P28845 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 6630 | P28845 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 142242 | P28845 | Espacenet |
1 to 10 of 58
See all 58 patentsDrugs7
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABT-384 | CHEMBL4297256 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitor | INHIBITOR | ChEMBL |
| AZD-4017 | CHEMBL2153191 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitor | INHIBITOR | ChEMBL |
| BI-187004 | CHEMBL3669417 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitor | INHIBITOR | ChEMBL |
| BMS-823778 | CHEMBL4297457 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitor | INHIBITOR | ChEMBL |
| BMS-823778 FREE BASE | CHEMBL4301600 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitor | INHIBITOR | ChEMBL |
| CARBENOXOLONE | CHEMBL499915 | 11-beta-hydroxysteroid dehydrogenase inhibitor | INHIBITOR | ChEMBL |
| MK-0736 | CHEMBL1761322 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitor | INHIBITOR | ChEMBL |
Trials11
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT03313297 | AZD-4017 | PHASE2 | ClinicalTrials.gov | |
| NCT02150824 | BI-187004 | PHASE2 | ClinicalTrials.gov | |
| NCT02017444 | AZD-4017 | PHASE2 | 2021-10-27 | ClinicalTrials.gov |
| NCT01874483 | BI-187004 | PHASE1 | ClinicalTrials.gov | |
| NCT01666704 | BMS-823778 | PHASE2 | ClinicalTrials.gov | |
| NCT01602367 | BMS-823778 | PHASE2 | ClinicalTrials.gov | |
| NCT01137526 | ABT-384 | PHASE2 | ClinicalTrials.gov | |
| NCT01111955 | BMS-823778 | PHASE2 | ClinicalTrials.gov | |
| NCT00806585 | MK-0736 | PHASE2 | 2013-12-11 | ClinicalTrials.gov |
| NCT00679055 | MK-0736 | PHASE1 | 2015-02-16 | ClinicalTrials.gov |
1 to 10 of 11
See all 11 trialsNIH grants1,239
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HSD11B1 papers | Newest fiscal year |
|---|---|---|---|
| ZIAES090057 | Glucocorticoid Hormone Action | 7 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 4 | 2025 |
| P30DK017047 | Diabetes Research Center | 4 | 2025 |
| P30DK079626 | UAB Diabetes Research Center | 4 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 4 | 2025 |
| P30CA077598 | Cancer Center Support Grant | 3 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 3 | 2025 |
| P30ES023515 | Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS) | 3 | 2025 |
| R01AR073004 | Mechanism of action and function of novel secosteroid 20(OH)D3 in the skin | 3 | 2025 |
| U54GM115428 | Mississippi Center for Clinical and Translational Research | 3 | 2025 |
1 to 10 of 1,239Source NIH's project files
See all 1,239 nih grantsPapers3,100
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Species differences in hepatic microsomal coumarin metabolism: A role for 11β-hydroxysteroid dehydrogenase type 1. | Food Chem Toxicol | 2026 | 42810542 | PubTator, text mining | PubMed |
| In-silico study of active phytochemicals and molecular mechanism of Hydrocotyle javanica Thunb.in treating MDR enterobacterial infection. | Bioresour Bioprocess | 2026 | 42622723 | PubTator, text mining | PubMed |
| Endocrine regulation of cardiac fibrosis: implications for HFpEF. | Front Endocrinol (Lausanne) | 2026 | 42602176 | PubTator, text mining | PubMed |
| ABRL8301, a novel 2-methoxyestradiol derivative, mitigates progressive pulmonary fibrosis by downregulating 11β-hydroxysteroid dehydrogenase 1. | Eur J Pharmacol | 2026 | 42580509 | PubTator, text mining | PubMed |
| Osthole and matrine suppress malignant progression of lead-exposed NSCLC via regulating cellular homeostasis: A combined network pharmacology and in vitro experimental study. | Phytomedicine | 2026 | 42555991 | PubTator, text mining | PubMed |
| 11β-HSD1 may Aggravate Sepsis-associated Endothelial Dysfunction by Activating the NF-κB/MAPK Pathway and NLRP3 Inflammasome. | Curr Med Chem | 2026 | 42509676 | PubTator, text mining | PubMed |
| Evidence for de novo synthesis of corticosteroids in the human ovary. | Hum Reprod | 2026 | 42402373 | PubTator, text mining | PubMed |
| Mechanisms involved in the regulation of carbohydrate and lipid metabolism by oleanane-type pentacyclic triterpenes. | Biochem Pharmacol | 2026 | 42398867 | PubTator, text mining | PubMed |
| The roles, mechanisms, and therapeutic implications of glucocorticoids in glucose and lipid metabolism. | Mil Med Res | 2026 | 42199346 | PubTator, text mining | PubMed |
| Integrated cell-free DNA and omics genetic scores for early detection of gestational diabetes: evidence from a nationwide multicenter study. | J Matern Fetal Neonatal Med | 2026 | 42186414 | PubTator, text mining | PubMed |
1 to 10 of 3,100
See all 3,100 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3290
GET https://conductscience.org/api/genes/v1/3290/patents?page=2