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Gene · 3290

HSD11B1: hydroxysteroid 11-beta dehydrogenase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HSD11B1: hydroxysteroid 11-beta dehydrogenase 1. Genes, record 3290. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3290

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Gene

Symbol
HSD11B1
HGNC
Name
hydroxysteroid 11-beta dehydrogenase 1
HGNC
NCBI Gene ID
3290
NCBI Gene
HGNC ID
HGNC:5208
HGNC
Ensembl
ENSG00000117594
NCBI Gene
Aliases
11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P2884511-beta-hydroxysteroid dehydrogenase 129242Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449539P28845Espacenet
JP 2026004568 A2026-01-1449540P28845Espacenet
JP 2026004568 A2026-01-1449541P28845Espacenet
EP 4650780 A22025-11-198151P28845Espacenet
JP 2025517970 A2025-06-128151P28845Espacenet
US 11446398 B22022-09-2039271P28845Espacenet
US 11446398 B22022-09-2039272P28845Espacenet
US 11400116 B22022-08-023307P28845Espacenet
US 11400116 B22022-08-026630P28845Espacenet
JP 2022524081 A2022-04-27142242P28845Espacenet

1 to 10 of 58

See all 58 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABT-384CHEMBL429725611-beta-hydroxysteroid dehydrogenase 1 inhibitorINHIBITORChEMBL
AZD-4017CHEMBL215319111-beta-hydroxysteroid dehydrogenase 1 inhibitorINHIBITORChEMBL
BI-187004CHEMBL366941711-beta-hydroxysteroid dehydrogenase 1 inhibitorINHIBITORChEMBL
BMS-823778CHEMBL429745711-beta-hydroxysteroid dehydrogenase 1 inhibitorINHIBITORChEMBL
BMS-823778 FREE BASECHEMBL430160011-beta-hydroxysteroid dehydrogenase 1 inhibitorINHIBITORChEMBL
CARBENOXOLONECHEMBL49991511-beta-hydroxysteroid dehydrogenase inhibitorINHIBITORChEMBL
MK-0736CHEMBL176132211-beta-hydroxysteroid dehydrogenase 1 inhibitorINHIBITORChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03313297AZD-4017PHASE2ClinicalTrials.gov
NCT02150824BI-187004PHASE2ClinicalTrials.gov
NCT02017444AZD-4017PHASE22021-10-27ClinicalTrials.gov
NCT01874483BI-187004PHASE1ClinicalTrials.gov
NCT01666704BMS-823778PHASE2ClinicalTrials.gov
NCT01602367BMS-823778PHASE2ClinicalTrials.gov
NCT01137526ABT-384PHASE2ClinicalTrials.gov
NCT01111955BMS-823778PHASE2ClinicalTrials.gov
NCT00806585MK-0736PHASE22013-12-11ClinicalTrials.gov
NCT00679055MK-0736PHASE12015-02-16ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants1,239

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHSD11B1 papersNewest fiscal year
ZIAES090057Glucocorticoid Hormone Action72025
P30CA023108Cancer Center Support Grant42025
P30DK017047Diabetes Research Center42025
P30DK079626UAB Diabetes Research Center42025
P30ES013508Center of Excellence in Environmental Toxicology42025
P30CA077598Cancer Center Support Grant32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
P30ES023515Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS)32025
R01AR073004Mechanism of action and function of novel secosteroid 20(OH)D3 in the skin32025
U54GM115428Mississippi Center for Clinical and Translational Research32025

1 to 10 of 1,239Source NIH's project files

See all 1,239 nih grants

Papers3,100

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Species differences in hepatic microsomal coumarin metabolism: A role for 11β-hydroxysteroid dehydrogenase type 1.Food Chem Toxicol202642810542PubTator, text miningPubMed
In-silico study of active phytochemicals and molecular mechanism of Hydrocotyle javanica Thunb.in treating MDR enterobacterial infection.Bioresour Bioprocess202642622723PubTator, text miningPubMed
Endocrine regulation of cardiac fibrosis: implications for HFpEF.Front Endocrinol (Lausanne)202642602176PubTator, text miningPubMed
ABRL8301, a novel 2-methoxyestradiol derivative, mitigates progressive pulmonary fibrosis by downregulating 11β-hydroxysteroid dehydrogenase 1.Eur J Pharmacol202642580509PubTator, text miningPubMed
Osthole and matrine suppress malignant progression of lead-exposed NSCLC via regulating cellular homeostasis: A combined network pharmacology and in vitro experimental study.Phytomedicine202642555991PubTator, text miningPubMed
11β-HSD1 may Aggravate Sepsis-associated Endothelial Dysfunction by Activating the NF-κB/MAPK Pathway and NLRP3 Inflammasome.Curr Med Chem202642509676PubTator, text miningPubMed
Evidence for de novo synthesis of corticosteroids in the human ovary.Hum Reprod202642402373PubTator, text miningPubMed
Mechanisms involved in the regulation of carbohydrate and lipid metabolism by oleanane-type pentacyclic triterpenes.Biochem Pharmacol202642398867PubTator, text miningPubMed
The roles, mechanisms, and therapeutic implications of glucocorticoids in glucose and lipid metabolism.Mil Med Res202642199346PubTator, text miningPubMed
Integrated cell-free DNA and omics genetic scores for early detection of gestational diabetes: evidence from a nationwide multicenter study.J Matern Fetal Neonatal Med202642186414PubTator, text miningPubMed

1 to 10 of 3,100

See all 3,100 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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