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Gene · 3352

HTR1D: 5-hydroxytryptamine receptor 1D

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HTR1D: 5-hydroxytryptamine receptor 1D. Genes, record 3352. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3352

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Gene

Symbol
HTR1D
HGNC
Name
5-hydroxytryptamine receptor 1D
HGNC
NCBI Gene ID
3352
NCBI Gene
HGNC ID
HGNC:5289
HGNC
Ensembl
ENSG00000179546
NCBI Gene
Aliases
5-HT1D, HT1DA, HTR1DA, HTRL, RDC4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P282215-hydroxytryptamine receptor 1D3771Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435752P28221Espacenet
JP 2026004568 A2026-01-1435753P28221Espacenet
JP 2025529142 A2025-09-042002P28221Espacenet
US 12371689 B22025-07-292002P28221Espacenet
JP 2025062604 A2025-04-14391P28221Espacenet
US 11446398 B22022-09-20391P28221Espacenet
US 11400116 B22022-08-02298P28221Espacenet
JP 2022524081 A2022-04-27103362P28221Espacenet
US 10772934 B22020-09-151023P28221Espacenet
JP 2019158777 A2019-09-19756P28221Espacenet

1 to 10 of 32

See all 32 patents

Drugs28

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALMOTRIPTANCHEMBL1505Serotonin 1d (5-HT1d) receptor agonistAGONISTChEMBL
ALMOTRIPTAN MALATECHEMBL1200521Serotonin 1d (5-HT1d) receptor agonistAGONISTChEMBL
AMISULPRIDECHEMBL243712Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
DEXFENFLURAMINECHEMBL248702Serotonin (5-HT) receptor agonistAGONISTChEMBL
DEXFENFLURAMINE HYDROCHLORIDECHEMBL1887891Serotonin (5-HT) receptor agonistAGONISTChEMBL
DIHYDROERGOTAMINECHEMBL1732Serotonin 1d (5-HT1d) receptor agonistAGONISTChEMBL
DIHYDROERGOTAMINE MESYLATECHEMBL1200517Serotonin 1d (5-HT1d) receptor agonistAGONISTChEMBL
DONITRIPTANCHEMBL1742428Serotonin 1d (5-HT1d) receptor agonistAGONISTChEMBL
ELETRIPTANCHEMBL1510Serotonin 1d (5-HT1d) receptor agonistAGONISTChEMBL
ELETRIPTAN HYDROBROMIDECHEMBL1201003Serotonin 1d (5-HT1d) receptor agonistAGONISTChEMBL

1 to 10 of 28

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Trials214

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07555171FENFLURAMINEClinicalTrials.gov
NCT07503444FENFLURAMINE HYDROCHLORIDEPHASE3ClinicalTrials.gov
NCT07152184AMISULPRIDEPHASE2ClinicalTrials.gov
NCT07112365FENFLURAMINEPHASE4ClinicalTrials.gov
NCT07103694SUMATRIPTANClinicalTrials.gov
NCT06887621AMISULPRIDEPHASE2ClinicalTrials.gov
NCT06868953SUMATRIPTANClinicalTrials.gov
NCT06677229ELETRIPTAN HYDROBROMIDEPHASE1/PHASE2ClinicalTrials.gov
NCT06598449FENFLURAMINEPHASE4ClinicalTrials.gov
NCT06585540AMISULPRIDEPHASE3ClinicalTrials.gov

1 to 10 of 214

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NIH grants552

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHTR1D papersNewest fiscal year
ZIAMH002793PET Radiopharmaceutical Sciences62025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
ZIAMH002795Translational Evaluation of PET Radiotracers42025
R01MH112205Molecular Details of Psychoactive Drug Actions32025
T32DE014318Craniofacial Oral-biology Student Training in Academic Research (COSTAR)22025
ZIADA000522Preclinical medication development for stimulant use disorder22025
I01CX001301Effects of ADT on motivation and emotion function in prostate cancer patients: longitudinal imaging and prediction12025
P01CA019014Viral Oncogenesis, Latency, and Replication12025
P20GM103427Nebraska Research Network in Functional Genomics12025
P20GM103430Rhode Island IDeA Network of Biomedical Research Excellence12025

1 to 10 of 552Source NIH's project files

See all 552 nih grants

Papers1,118

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Antidepressant Vortioxetine Potently Inhibits Cell Growth in Cultured Human Glioblastoma Cells Expressing 5-HT1B Serotonin Receptors.Cells202642587732PubTator, text miningPubMed
A three-gene signature correlated with MAPK/ERK activation characterizes acquired resistance to EGFR-tyrosine kinase inhibitors in non-small cell lung cancer.Oncol Lett202642516805PubTator, text miningPubMed
Pharmaco-behavioral profiling identifies suppressors of autism gene-associated phenotypes in zebrafish.Proc Natl Acad Sci U S A202641838920PubTator, text miningPubMed
Neuroimmunological Mechanisms of Xiao-Yao-San Against Chronic Stress-Induced Colorectal Cancer: A Bioinformatics and Single-Cell Sequencing Study.Cancer Manag Res202641798904PubTator, text miningPubMed
Differential conservation analysis identifies residues defining constitutive internalization in beta-adrenergic receptors.iScience202641797919PubTator, text miningPubMed
Coronary Artery Spasm in Patients with Type 2 Diabetes Mellitus.Life (Basel)202641752989PubTator, text miningPubMed
Emotional Blunting in Hong Kong Patients with Major Depressive Disorder Treated with Vortioxetine: A Naturalistic Observational Study.Biomedicines202641751169PubTator, text miningPubMed
Acute psilocin increased cortical activity in rat.Front Neurosci202641716660PubTator, text miningPubMed
Management strategies for burning mouth syndrome: a comprehensive review.J Oral Facial Pain Headache202641607318PubTator, text miningPubMed
Decoding Non-Neuronal Mechanisms and Therapeutic Targets in Huntington's Disease Through Integrative Transcriptomics and Machine Learning.J Mol Neurosci202641553597PubTator, text miningPubMed

1 to 10 of 1,118

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3352

GET https://conductscience.org/api/genes/v1/3352/patents?page=2