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Gene · 3360

HTR4: 5-hydroxytryptamine receptor 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HTR4: 5-hydroxytryptamine receptor 4. Genes, record 3360. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3360

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Gene

Symbol
HTR4
HGNC
Name
5-hydroxytryptamine receptor 4
HGNC
NCBI Gene ID
3360
NCBI Gene
HGNC ID
HGNC:5299
HGNC
Ensembl
ENSG00000164270
NCBI Gene
Aliases
5-HT4, 5-HT4R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q136395-hydroxytryptamine receptor 43884Ensembl, GeneID, HGNC

Source UniProt

Patents47

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1051Q13639Espacenet
JP 2026004568 A2026-01-1435782Q13639Espacenet
EP 4641201 A22025-10-2910250Q13639Espacenet
JP 2025529142 A2025-09-042013Q13639Espacenet
US 12371689 B22025-07-292013Q13639Espacenet
JP 2025517969 A2025-06-1210250Q13639Espacenet
JP 2025062604 A2025-04-14424Q13639Espacenet
JP 2025062604 A2025-04-14432Q13639Espacenet
WO 2024251866 A12024-12-1229Q13639Espacenet
JP 2023156353 A2023-10-2451Q13639Espacenet

1 to 10 of 47

See all 47 patents

Drugs25

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMISULPRIDECHEMBL243712Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
CAPESERODCHEMBL2027925Serotonin 4 (5-HT4) receptor partial agonistPARTIAL AGONISTChEMBL
CISAPRIDECHEMBL1729Serotonin 4 (5-HT4) receptor agonistAGONISTChEMBL
CISAPRIDE MONOHYDRATECHEMBL1200788Serotonin 4 (5-HT4) receptor agonistAGONISTChEMBL
CLEBOPRIDECHEMBL325109Serotonin 4 (5-HT4) receptor agonistAGONISTChEMBL
DEXFENFLURAMINECHEMBL248702Serotonin (5-HT) receptor agonistAGONISTChEMBL
DEXFENFLURAMINE HYDROCHLORIDECHEMBL1887891Serotonin (5-HT) receptor agonistAGONISTChEMBL
FELCISETRAGCHEMBL2402904Serotonin 4 (5-HT4) receptor agonistAGONISTChEMBL
LEVOSULPIRIDECHEMBL267044Serotonin 4 (5-HT4) receptor agonistAGONISTChEMBL
METOCLOPRAMIDECHEMBL86Serotonin 4 (5-HT4) receptor agonistAGONISTChEMBL

1 to 10 of 25

See all 25 drugs

Trials165

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07152184AMISULPRIDEPHASE2ClinicalTrials.gov
NCT06887621AMISULPRIDEPHASE2ClinicalTrials.gov
NCT06789614METOCLOPRAMIDEClinicalTrials.gov
NCT06585540AMISULPRIDEPHASE3ClinicalTrials.gov
NCT06581302AMISULPRIDEClinicalTrials.gov
NCT06474286PRUCALOPRIDEClinicalTrials.gov
NCT06390787METOCLOPRAMIDEPHASE2/PHASE3ClinicalTrials.gov
NCT06040944AMISULPRIDEClinicalTrials.gov
NCT05983354METOCLOPRAMIDEClinicalTrials.gov
NCT05967442METOCLOPRAMIDEPHASE32024-10-01ClinicalTrials.gov

1 to 10 of 165

See all 165 trials

NIH grants1,172

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHTR4 papersNewest fiscal year
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal72025
R01HL077612Precision phenotyping of emphysema in the elderly: the MESA Lung Study62025
ZIAES043012Genetics and Environment in Adult Respiratory, Allergic and Cardiac disease62025
P30DK063491Diabetes Research Center (DRC)52025
ZIAMH002793PET Radiopharmaceutical Sciences42025
P30CA016672Cancer Center Support Grant32025
R01DK114007Mechanisms of alteration of gastrointestinal physiology by gut microbes32025
R01EB026299BrainStorm: Highly Extensible Software for Advanced Electrophysiology and MEG/EEG Imaging32025
ZIAES025045Genetic Analyses For Epidemiologic Studies Of Respiratory Disease32025
P30CA008748Cancer Center Support Grant22025

1 to 10 of 1,172Source NIH's project files

See all 1,172 nih grants

Papers1,853

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Spatial correspondence between altered brain function and normative neurotransmitter density maps in Type 1 diabetes mellitus.J Endocrinol Invest202642667349PubTator, text miningPubMed
Exercise-related changes in depressive symptoms and their association with anterior cingulate cortical thickness.Int J Clin Health Psychol202642604120PubTator, text miningPubMed
[Advances in the Treatment of Refractory Pediatric Constipation].Acta Gastroenterol Latinoam202642569715PubTator, text miningPubMed
Mosapride promotes internalization of a TREK1-HTR4 complex and exerts rapid antidepressant-like effects.Mol Psychiatry202642542439PubTator, text miningPubMed
Nature, nurture, and 5-HT4R: Familial predisposition, not parental bonding, is associated with brain 5-HT4R in a sex-specific manner.Psychiatry Clin Neurosci202642541429PubTator, text miningPubMed
Serotonergic Signaling in Gastric Physiology and Motility Disorders.Gastroenterology202642486340PubTator, text miningPubMed
Regulation of spermatozoal capacitation by serotonin.J Reprod Dev202642402414PubTator, text miningPubMed
Effects on hippocampal activity following novel 5-HT4 receptor agonism in unmedicated patients with depression: the RESTAND study.Transl Psychiatry202642309998PubTator, text miningPubMed
Pro-cognitive effects of 5-HT4 receptor agonism in individuals with remitted depression.Psychol Med202642290157PubTator, text miningPubMed
Selective molecular and network architecture features underlie brain cortical atrophy in dementia with Lewy bodies.J Biomed Sci202642265698PubTator, text miningPubMed

1 to 10 of 1,853

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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