Gene · 3360
HTR4: 5-hydroxytryptamine receptor 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HTR4: 5-hydroxytryptamine receptor 4. Genes, record 3360. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3360
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13639 | 5-hydroxytryptamine receptor 4 | 388 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents47
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026062654 A | 2026-04-10 | 51 | Q13639 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 35782 | Q13639 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 10250 | Q13639 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2013 | Q13639 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2013 | Q13639 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10250 | Q13639 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 424 | Q13639 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 432 | Q13639 | Espacenet |
| WO 2024251866 A1 | 2024-12-12 | 29 | Q13639 | Espacenet |
| JP 2023156353 A | 2023-10-24 | 51 | Q13639 | Espacenet |
1 to 10 of 47
See all 47 patentsDrugs25
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMISULPRIDE | CHEMBL243712 | Serotonin (5-HT) receptor antagonist | ANTAGONIST | ChEMBL |
| CAPESEROD | CHEMBL2027925 | Serotonin 4 (5-HT4) receptor partial agonist | PARTIAL AGONIST | ChEMBL |
| CISAPRIDE | CHEMBL1729 | Serotonin 4 (5-HT4) receptor agonist | AGONIST | ChEMBL |
| CISAPRIDE MONOHYDRATE | CHEMBL1200788 | Serotonin 4 (5-HT4) receptor agonist | AGONIST | ChEMBL |
| CLEBOPRIDE | CHEMBL325109 | Serotonin 4 (5-HT4) receptor agonist | AGONIST | ChEMBL |
| DEXFENFLURAMINE | CHEMBL248702 | Serotonin (5-HT) receptor agonist | AGONIST | ChEMBL |
| DEXFENFLURAMINE HYDROCHLORIDE | CHEMBL1887891 | Serotonin (5-HT) receptor agonist | AGONIST | ChEMBL |
| FELCISETRAG | CHEMBL2402904 | Serotonin 4 (5-HT4) receptor agonist | AGONIST | ChEMBL |
| LEVOSULPIRIDE | CHEMBL267044 | Serotonin 4 (5-HT4) receptor agonist | AGONIST | ChEMBL |
| METOCLOPRAMIDE | CHEMBL86 | Serotonin 4 (5-HT4) receptor agonist | AGONIST | ChEMBL |
1 to 10 of 25
See all 25 drugsTrials165
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07152184 | AMISULPRIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06887621 | AMISULPRIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06789614 | METOCLOPRAMIDE | ClinicalTrials.gov | ||
| NCT06585540 | AMISULPRIDE | PHASE3 | ClinicalTrials.gov | |
| NCT06581302 | AMISULPRIDE | ClinicalTrials.gov | ||
| NCT06474286 | PRUCALOPRIDE | ClinicalTrials.gov | ||
| NCT06390787 | METOCLOPRAMIDE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT06040944 | AMISULPRIDE | ClinicalTrials.gov | ||
| NCT05983354 | METOCLOPRAMIDE | ClinicalTrials.gov | ||
| NCT05967442 | METOCLOPRAMIDE | PHASE3 | 2024-10-01 | ClinicalTrials.gov |
1 to 10 of 165
See all 165 trialsNIH grants1,172
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HTR4 papers | Newest fiscal year |
|---|---|---|---|
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 7 | 2025 |
| R01HL077612 | Precision phenotyping of emphysema in the elderly: the MESA Lung Study | 6 | 2025 |
| ZIAES043012 | Genetics and Environment in Adult Respiratory, Allergic and Cardiac disease | 6 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 5 | 2025 |
| ZIAMH002793 | PET Radiopharmaceutical Sciences | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| R01DK114007 | Mechanisms of alteration of gastrointestinal physiology by gut microbes | 3 | 2025 |
| R01EB026299 | BrainStorm: Highly Extensible Software for Advanced Electrophysiology and MEG/EEG Imaging | 3 | 2025 |
| ZIAES025045 | Genetic Analyses For Epidemiologic Studies Of Respiratory Disease | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 1,172Source NIH's project files
See all 1,172 nih grantsPapers1,853
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Spatial correspondence between altered brain function and normative neurotransmitter density maps in Type 1 diabetes mellitus. | J Endocrinol Invest | 2026 | 42667349 | PubTator, text mining | PubMed |
| Exercise-related changes in depressive symptoms and their association with anterior cingulate cortical thickness. | Int J Clin Health Psychol | 2026 | 42604120 | PubTator, text mining | PubMed |
| [Advances in the Treatment of Refractory Pediatric Constipation]. | Acta Gastroenterol Latinoam | 2026 | 42569715 | PubTator, text mining | PubMed |
| Mosapride promotes internalization of a TREK1-HTR4 complex and exerts rapid antidepressant-like effects. | Mol Psychiatry | 2026 | 42542439 | PubTator, text mining | PubMed |
| Nature, nurture, and 5-HT4R: Familial predisposition, not parental bonding, is associated with brain 5-HT4R in a sex-specific manner. | Psychiatry Clin Neurosci | 2026 | 42541429 | PubTator, text mining | PubMed |
| Serotonergic Signaling in Gastric Physiology and Motility Disorders. | Gastroenterology | 2026 | 42486340 | PubTator, text mining | PubMed |
| Regulation of spermatozoal capacitation by serotonin. | J Reprod Dev | 2026 | 42402414 | PubTator, text mining | PubMed |
| Effects on hippocampal activity following novel 5-HT4 receptor agonism in unmedicated patients with depression: the RESTAND study. | Transl Psychiatry | 2026 | 42309998 | PubTator, text mining | PubMed |
| Pro-cognitive effects of 5-HT4 receptor agonism in individuals with remitted depression. | Psychol Med | 2026 | 42290157 | PubTator, text mining | PubMed |
| Selective molecular and network architecture features underlie brain cortical atrophy in dementia with Lewy bodies. | J Biomed Sci | 2026 | 42265698 | PubTator, text mining | PubMed |
1 to 10 of 1,853
See all 1,853 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3360
GET https://conductscience.org/api/genes/v1/3360/patents?page=2