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Gene · 3452

IFNA21: interferon alpha 21

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IFNA21: interferon alpha 21. Genes, record 3452. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3452

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Gene

Symbol
IFNA21
HGNC
Name
interferon alpha 21
HGNC
NCBI Gene ID
3452
NCBI Gene
HGNC ID
HGNC:5424
HGNC
Ensembl
ENSG00000137080
NCBI Gene
Aliases
IFN-alphaI, LeIF F, leIF-F
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P01568Interferon alpha-211890Ensembl, GeneID, HGNC

Source UniProt

Patents79

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4724500 A22026-04-15426P01568Espacenet
EP 4705273 A22026-03-11541P01568Espacenet
EP 4650780 A22025-11-1910286P01568Espacenet
JP 2025169942 A2025-11-141097P01568Espacenet
JP 2025147176 A2025-10-066733P01568Espacenet
JP 2025529142 A2025-09-046652P01568Espacenet
US 12371689 B22025-07-296652P01568Espacenet
JP 2025517970 A2025-06-1210286P01568Espacenet
JP 2025028160 A2025-02-286733P01568Espacenet
JP 2025013347 A2025-01-24541P01568Espacenet

1 to 10 of 79

See all 79 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
RONTALIZUMABCHEMBL1743066Interferon alpha inhibitorINHIBITORChEMBL
SIFALIMUMABCHEMBL1743069Interferon alpha inhibitorINHIBITORChEMBL

Trials10

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01283139SIFALIMUMABPHASE22016-07-11ClinicalTrials.gov
NCT01031836SIFALIMUMABPHASE22018-11-19ClinicalTrials.gov
NCT00979654SIFALIMUMABPHASE22016-08-23ClinicalTrials.gov
NCT00962832RONTALIZUMABPHASE2ClinicalTrials.gov
NCT00657189SIFALIMUMABPHASE2ClinicalTrials.gov
NCT00541749RONTALIZUMABPHASE1ClinicalTrials.gov
NCT00533091SIFALIMUMABPHASE1ClinicalTrials.gov
NCT00482989SIFALIMUMABPHASE1ClinicalTrials.gov
NCT00472758SIFALIMUMABPHASE1ClinicalTrials.gov
NCT00299819SIFALIMUMABPHASE1ClinicalTrials.gov

NIH grants332

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIFNA21 papersNewest fiscal year
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success52025
R01AI163029Inborn errors of immunity in patients with life-threatening COVID-1932025
P30CA008748Cancer Center Support Grant22025
P51OD010425Washington National Primate Research Center22025
UL1TR001863Yale Clinical and Translational Science Award22025
ZIAAI000887Role of HIV Envelope Proteins In Viral Replication and HIV Pathogenesis22025
I01CX002422Investigate the mechanism of autoreactive B cell-mediated immunological failure despite virologic suppression in HIV-infected individuals on antiretroviral therapy12025
K01HL157755Tissue-specific functional genomics in the acute respiratory distress syndrome12025
K08AI163493Innate Control of Adaptive Immunity to SARS-CoV-212025
K24AR076975Linking Disease Mechanisms and Outcomes in Rheumatic Diseases12025

1 to 10 of 332Source NIH's project files

See all 332 nih grants

Papers292

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Human CD3 complex is required for the generation of T-cell receptor-like chimeric antigen receptor targeting WT1 in natural killer cells.Cancer Immunol Immunother202641843174PubTator, text miningPubMed
Essential role of hsa-miR-203a-3p in type I interferons immune homeostasis during influenza and NDV infection.RNA Biol202641784292PubTator, text miningPubMed
Fetal and Neonatal Immune Response to Congenital Cytomegalovirus (cCMV) Infection: A Systematically Conducted Scoping Review.Viruses202641754585PubTator, text miningPubMed
Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function.Nat Immunol202641540267PubTator, text miningPubMed
Identification of Transcriptional Regulators of Immune Evasion Across Cancers: An Alternative Immunotherapeutic Strategy for Cholangiocarcinoma.Cancers (Basel)202439766097PubTator, text miningPubMed
Unveiling the therapeutic prospects of IFNW1 and IFNA21: insights into glioma pathogenesis and clinical significance.Neurogenetics202438958838PubTator, text miningPubMed
Inhibition of SARS-CoV-2 infection and replication by Petasites hybridus CO2-extract (Ze 339).Biomed Pharmacother202438061134PubTator, text miningPubMed
A genome-wide and candidate gene association study of preterm birth in Korean pregnant women.PLoS One202338019868PubTator, text miningPubMed
Targeted mutations in IFNα2 improve its antiviral activity against various viruses.mBio202337874130PubTator, text miningPubMed
Rare genetic variants involved in multisystem inflammatory syndrome in children: a multicenter Brazilian cohort study.Front Cell Infect Microbiol202337588055PubTator, text miningPubMed

1 to 10 of 292

See all 292 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3452

GET https://conductscience.org/api/genes/v1/3452/patents?page=2