Gene · 347688
TUBB8: tubulin beta 8 class VIII
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TUBB8: tubulin beta 8 class VIII. Genes, record 347688. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/347688
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q3ZCM7 | Tubulin beta-8 chain | 444 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents13
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4689071 A2 | 2026-02-11 | 10 | Q3ZCM7 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 5521 | Q3ZCM7 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 93621 | Q3ZCM7 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 196592 | Q3ZCM7 | Espacenet |
| EP 3585909 A1 | 2020-01-01 | 351 | Q3ZCM7 | Espacenet |
| KR 1020190126812 A | 2019-11-12 | 351 | Q3ZCM7 | Espacenet |
| US 10463751 B2 | 2019-11-05 | 5521 | Q3ZCM7 | Espacenet |
| JP 2018023373 A | 2018-02-15 | 28248 | Q3ZCM7 | Espacenet |
| US 9572897 B2 | 2017-02-21 | 5521 | Q3ZCM7 | Espacenet |
| US 9303079 B2 | 2016-04-05 | 5521 | Q3ZCM7 | Espacenet |
1 to 10 of 13
See all 13 patentsDrugs91
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABT-751 | CHEMBL20684 | Tubulin beta inhibitor | INHIBITOR | ChEMBL |
| AGS-16C3F | CHEMBL4594455 | Tubulin disrupting agent | DISRUPTING AGENT | ChEMBL |
| ANETUMAB RAVTANSINE | CHEMBL2109629 | Tubulin inhibitor | INHIBITOR | ChEMBL |
| ANG1005 | CHEMBL1089636 | Tubulin inhibitor | INHIBITOR | ChEMBL |
| ANVATABART OPADOTIN | CHEMBL4297892 | Tubulin inhibitor | INHIBITOR | ChEMBL |
| APRUTUMAB IXADOTIN | CHEMBL4650293 | Tubulin inhibitor | INHIBITOR | ChEMBL |
| ASG-5ME | CHEMBL2109574 | Tubulin inhibitor | INHIBITOR | ChEMBL |
| AVE-9633 | CHEMBL2109266 | Tubulin inhibitor | INHIBITOR | ChEMBL |
| AZINTUXIZUMAB VEDOTIN | CHEMBL4297859 | Tubulin inhibitor | INHIBITOR | ChEMBL |
| BELANTAMAB MAFODOTIN | CHEMBL4298209 | Tubulin inhibitor | INHIBITOR | ChEMBL |
1 to 10 of 91
See all 91 drugsTrials8,740
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07604766 | PACLITAXEL | PHASE3 | ClinicalTrials.gov | |
| NCT07602907 | PACLITAXEL | PHASE2 | ClinicalTrials.gov | |
| NCT07601737 | PACLITAXEL | PHASE2 | ClinicalTrials.gov | |
| NCT07601178 | PACLITAXEL | PHASE2 | ClinicalTrials.gov | |
| NCT07599163 | PACLITAXEL | ClinicalTrials.gov | ||
| NCT07595770 | PACLITAXEL | PHASE2 | ClinicalTrials.gov | |
| NCT07594548 | PACLITAXEL | PHASE1 | ClinicalTrials.gov | |
| NCT07591467 | DOCETAXEL | PHASE3 | ClinicalTrials.gov | |
| NCT07589972 | VINORELBINE | ClinicalTrials.gov | ||
| NCT07588698 | VINCRISTINE SULFATE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 8,740
See all 8,740 trialsNIH grants192
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TUBB8 papers | Newest fiscal year |
|---|---|---|---|
| P30CA015704 | Cancer Center Support Grant | 2 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 2 | 2025 |
| R01HD091331 | Understanding genetic risk for aneuploid conception | 2 | 2025 |
| ZIAAI000615 | Molecular Analysis Of Leukocyte Activation By Chemoattractants | 2 | 2025 |
| F30HD107976 | Functional evaluation of kinesin gene variants associated with female subfertility and egg aneuploidy. | 1 | 2025 |
| K12HD000849 | Reproductive Scientist Development Program | 1 | 2025 |
| K12HD000850 | Pediatric Scientist Development Program | 1 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 1 | 2025 |
| P20GM109036 | Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases | 1 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 1 | 2025 |
1 to 10 of 192Source NIH's project files
See all 192 nih grantsPapers278
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Novel and recurrent TUBB8 variants cause irreversible meiotic spindle defects and refractory ART failure in Chinese women with oocyte maturation arrest. | J Assist Reprod Genet | 2026 | 42760497 | PubTator, text mining | PubMed |
| Spontaneous natural conception and live birth in three patients with likely pathogenic variants in TUBB8, ZP2, and ZP3 associated with female subfertility. | J Ovarian Res | 2026 | 42458583 | PubTator, text mining | PubMed |
| Gene panel analysis for oocyte/zygote/embryo maturation arrest in female infertility: a multicenter study in Japan. | Sci Rep | 2026 | 42409946 | PubTator, text mining | PubMed |
| Deciphering the role of tubulin's C-terminal tail in kinesin binding using computational and clustering approaches. | Sci Rep | 2026 | 42168523 | PubTator, text mining | PubMed |
| Lessons learned from the exome sequencing of nine cases of infertility and the way forward. | Reprod Biomed Online | 2026 | 41932285 | PubTator, text mining | PubMed |
| Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest. | Int J Mol Sci | 2026 | 41828362 | PubTator, text mining | PubMed |
| TUBB8 variants in infertile Japanese women, including a novel homozygous nonsense variant causing zygote multinucleation. | Reprod Biomed Online | 2026 | 41762928 | PubTator, text mining | PubMed |
| Functional Analysis of a Novel Missense Mutation c.1039A > G of TUBB8 in Infertile Women. | Biochem Genet | 2026 | 40601103 | PubTator, text mining | PubMed |
| [Analysis of a case with oocyte maturation disorder caused by a heterozygous c.728C>T (p.P243L) missense variant of TUBB8 gene and literature review]. | Zhonghua Yi Xue Yi Chuan Xue Za Zhi | 2025 | 41070645 | PubTator, text mining | PubMed |
| Neurodevelopmental status of children aged 12 to 60 months conceived with artificial oocyte activation in a Cross-Sectional study. | Sci Rep | 2025 | 40731130 | PubTator, text mining | PubMed |
1 to 10 of 278
See all 278 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/347688
GET https://conductscience.org/api/genes/v1/347688/patents