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Gene · 347688

TUBB8: tubulin beta 8 class VIII

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TUBB8: tubulin beta 8 class VIII. Genes, record 347688. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/347688

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Gene

Symbol
TUBB8
HGNC
Name
tubulin beta 8 class VIII
HGNC
NCBI Gene ID
347688
NCBI Gene
HGNC ID
HGNC:20773
HGNC
Ensembl
ENSG00000261456
NCBI Gene
Aliases
OOMD, OOMD2, OZEMA2, bA631M21.2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q3ZCM7Tubulin beta-8 chain4440Ensembl, GeneID, HGNC

Source UniProt

Patents13

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4689071 A22026-02-1110Q3ZCM7Espacenet
US 11564998 B22023-01-315521Q3ZCM7Espacenet
US 11446398 B22022-09-2093621Q3ZCM7Espacenet
JP 2022524081 A2022-04-27196592Q3ZCM7Espacenet
EP 3585909 A12020-01-01351Q3ZCM7Espacenet
KR 1020190126812 A2019-11-12351Q3ZCM7Espacenet
US 10463751 B22019-11-055521Q3ZCM7Espacenet
JP 2018023373 A2018-02-1528248Q3ZCM7Espacenet
US 9572897 B22017-02-215521Q3ZCM7Espacenet
US 9303079 B22016-04-055521Q3ZCM7Espacenet

1 to 10 of 13

See all 13 patents

Drugs91

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABT-751CHEMBL20684Tubulin beta inhibitorINHIBITORChEMBL
AGS-16C3FCHEMBL4594455Tubulin disrupting agentDISRUPTING AGENTChEMBL
ANETUMAB RAVTANSINECHEMBL2109629Tubulin inhibitorINHIBITORChEMBL
ANG1005CHEMBL1089636Tubulin inhibitorINHIBITORChEMBL
ANVATABART OPADOTINCHEMBL4297892Tubulin inhibitorINHIBITORChEMBL
APRUTUMAB IXADOTINCHEMBL4650293Tubulin inhibitorINHIBITORChEMBL
ASG-5MECHEMBL2109574Tubulin inhibitorINHIBITORChEMBL
AVE-9633CHEMBL2109266Tubulin inhibitorINHIBITORChEMBL
AZINTUXIZUMAB VEDOTINCHEMBL4297859Tubulin inhibitorINHIBITORChEMBL
BELANTAMAB MAFODOTINCHEMBL4298209Tubulin inhibitorINHIBITORChEMBL

1 to 10 of 91

See all 91 drugs

Trials8,740

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604766PACLITAXELPHASE3ClinicalTrials.gov
NCT07602907PACLITAXELPHASE2ClinicalTrials.gov
NCT07601737PACLITAXELPHASE2ClinicalTrials.gov
NCT07601178PACLITAXELPHASE2ClinicalTrials.gov
NCT07599163PACLITAXELClinicalTrials.gov
NCT07595770PACLITAXELPHASE2ClinicalTrials.gov
NCT07594548PACLITAXELPHASE1ClinicalTrials.gov
NCT07591467DOCETAXELPHASE3ClinicalTrials.gov
NCT07589972VINORELBINEClinicalTrials.gov
NCT07588698VINCRISTINE SULFATEPHASE2ClinicalTrials.gov

1 to 10 of 8,740

See all 8,740 trials

NIH grants192

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTUBB8 papersNewest fiscal year
P30CA015704Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
R01HD091331Understanding genetic risk for aneuploid conception22025
ZIAAI000615Molecular Analysis Of Leukocyte Activation By Chemoattractants22025
F30HD107976Functional evaluation of kinesin gene variants associated with female subfertility and egg aneuploidy.12025
K12HD000849Reproductive Scientist Development Program12025
K12HD000850Pediatric Scientist Development Program12025
P01CA092584Structural Cell Biology of DNA Repair Machines12025
P20GM109036Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases12025
P30CA030199Cancer Center Support Grant (CCSG)12025

1 to 10 of 192Source NIH's project files

See all 192 nih grants

Papers278

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Novel and recurrent TUBB8 variants cause irreversible meiotic spindle defects and refractory ART failure in Chinese women with oocyte maturation arrest.J Assist Reprod Genet202642760497PubTator, text miningPubMed
Spontaneous natural conception and live birth in three patients with likely pathogenic variants in TUBB8, ZP2, and ZP3 associated with female subfertility.J Ovarian Res202642458583PubTator, text miningPubMed
Gene panel analysis for oocyte/zygote/embryo maturation arrest in female infertility: a multicenter study in Japan.Sci Rep202642409946PubTator, text miningPubMed
Deciphering the role of tubulin's C-terminal tail in kinesin binding using computational and clustering approaches.Sci Rep202642168523PubTator, text miningPubMed
Lessons learned from the exome sequencing of nine cases of infertility and the way forward.Reprod Biomed Online202641932285PubTator, text miningPubMed
Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.Int J Mol Sci202641828362PubTator, text miningPubMed
TUBB8 variants in infertile Japanese women, including a novel homozygous nonsense variant causing zygote multinucleation.Reprod Biomed Online202641762928PubTator, text miningPubMed
Functional Analysis of a Novel Missense Mutation c.1039A > G of TUBB8 in Infertile Women.Biochem Genet202640601103PubTator, text miningPubMed
[Analysis of a case with oocyte maturation disorder caused by a heterozygous c.728C>T (p.P243L) missense variant of TUBB8 gene and literature review].Zhonghua Yi Xue Yi Chuan Xue Za Zhi202541070645PubTator, text miningPubMed
Neurodevelopmental status of children aged 12 to 60 months conceived with artificial oocyte activation in a Cross-Sectional study.Sci Rep202540731130PubTator, text miningPubMed

1 to 10 of 278

See all 278 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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