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Gene · 3588

IL10RB: interleukin 10 receptor subunit beta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IL10RB: interleukin 10 receptor subunit beta. Genes, record 3588. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3588

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Gene

Symbol
IL10RB
HGNC
Name
interleukin 10 receptor subunit beta
HGNC
NCBI Gene ID
3588
NCBI Gene
HGNC ID
HGNC:5965
HGNC
Ensembl
ENSG00000243646
NCBI Gene
Aliases
CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IBD25, IL-10R2, IL-10RB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q08334Interleukin-10 receptor subunit beta3255Ensembl, GeneID, HGNC

Source UniProt

Patents101

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026086659 A2026-05-26166Q08334Espacenet
EP 4705273 A22026-03-11305Q08334Espacenet
WO 2026019692 A22026-01-225Q08334Espacenet
US 12528850 B22026-01-2053Q08334Espacenet
EP 4650780 A22025-11-193416Q08334Espacenet
EP 4641201 A22025-10-292996Q08334Espacenet
JP 2025160224 A2025-10-2253Q08334Espacenet
JP 2025134781 A2025-09-17456Q08334Espacenet
JP 2025529142 A2025-09-042067Q08334Espacenet
JP 2025525778 A2025-08-075Q08334Espacenet

1 to 10 of 101

See all 101 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EFLEPEDOCOKIN ALFACHEMBL4594542IL22 Receptor agonistAGONISTChEMBL
PEGILODECAKINCHEMBL3989992IL-10 receptor agonistAGONISTChEMBL
PEGINTERFERON LAMBDA-1ACHEMBL2108723Interferon lambda receptor agonistAGONISTChEMBL

Trials30

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05953545PEGINTERFERON LAMBDA-1APHASE2ClinicalTrials.gov
NCT05205668EFLEPEDOCOKIN ALFAPHASE2ClinicalTrials.gov
NCT04967430PEGINTERFERON LAMBDA-1APHASE3ClinicalTrials.gov
NCT04534673PEGINTERFERON LAMBDA-1APHASE2ClinicalTrials.gov
NCT04498377EFLEPEDOCOKIN ALFAPHASE22023-12-21ClinicalTrials.gov
NCT04388709PEGINTERFERON LAMBDA-1APHASE2ClinicalTrials.gov
NCT04354259PEGINTERFERON LAMBDA-1APHASE2ClinicalTrials.gov
NCT04344600PEGINTERFERON LAMBDA-1APHASE22022-07-14ClinicalTrials.gov
NCT04343976PEGINTERFERON LAMBDA-1APHASE22022-07-21ClinicalTrials.gov
NCT04331899PEGINTERFERON LAMBDA-1APHASE22021-04-22ClinicalTrials.gov

1 to 10 of 30

See all 30 trials

NIH grants1,732

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIL10RB papersNewest fiscal year
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success222025
P30DK034854Integrated Epithelial and Muscosal Biology172025
P30CA008748Cancer Center Support Grant92025
P30CA046934University of Colorado Cancer Center Support Grant82025
R01AI163029Inborn errors of immunity in patients with life-threatening COVID-1982025
P30CA016672Cancer Center Support Grant72025
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis72025
RC2DK118640COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository62025
P01CA018029Adult Leukemia Research Center52025
P30CA015704Cancer Center Support Grant52025

1 to 10 of 1,732Source NIH's project files

See all 1,732 nih grants

Papers2,588

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of genetic variants associated with monogenic autoinflammatory diseases in patients with Still's disease using next-generation sequencing.Immunol Res202642821198PubTator, text miningPubMed
Interferon-λ receptor positive monocytes/macrophages orchestrate a pro-fibrotic immune environment in hepatitis B virus-related liver fibrosis.Clin Sci (Lond)202642742113PubTator, text miningPubMed
Connecting Skin and Gut in Dermatitis Herpetiformis: Insights from Gluten Challenge Transcriptomics.Acta Derm Venereol202642713962PubTator, text miningPubMed
Gut microbiota-derived metabolites and IL-22 signaling in inflammatory bowel disease: context-dependent regulation of mucosal repair and inflammation.Front Immunol202642713082PubTator, text miningPubMed
Genetic and autoimmune predispositions to fulminant viral hepatitis in children.Front Immunol202642630887PubTator, text miningPubMed
Single-cell and spatial profiling reveal an IL-10-associated iCAF-M2 macrophage communication axis in high-grade serous ovarian cancer ascites.Front Immunol202642500684PubTator, text miningPubMed
Systemic inflammatory networks in HIV-associated chronic obstructive pulmonary disease.J Infect202642456981PubTator, text miningPubMed
Serum Proteomic Profiles of Microvascular Inflammation in Donor-specific Antibody-negative and C4d-negative in Kidney Transplantation.Transplantation202642441560PubTator, text miningPubMed
Genotype-phenotype correlations in autoimmune and autoinflammatory diseases: An NGS-based immunogenetic cohort study.Immunogenetics202642406132PubTator, text miningPubMed
A preliminary analysis of the inflammatory protein landscape in the CSF of mid- to late-stage Parkinson's disease: associations with motor severity and subtypes.BMC Neurol202642387333PubTator, text miningPubMed

1 to 10 of 2,588

See all 2,588 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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