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Gene · 3601

IL15RA: interleukin 15 receptor subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IL15RA: interleukin 15 receptor subunit alpha. Genes, record 3601. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3601

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Gene

Symbol
IL15RA
HGNC
Name
interleukin 15 receptor subunit alpha
HGNC
NCBI Gene ID
3601
NCBI Gene
HGNC ID
HGNC:5978
HGNC
Ensembl
ENSG00000134470
NCBI Gene
Aliases
CD215, IL-15RA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13261Interleukin-15 receptor subunit alpha2674Ensembl, GeneID, HGNC

Source UniProt

Patents425

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4808601 A12026-09-23200Q13261Espacenet
WO 2026183237 A12026-09-03266Q13261Espacenet
EP 4795154 A12026-08-2626Q13261Espacenet
EP 4791785 A12026-08-1911Q13261Espacenet
EP 4791785 A12026-08-194Q13261Espacenet
US 12653839 B22026-06-16200Q13261Espacenet
JP 2026076241 A2026-05-113Q13261Espacenet
JP 2026076241 A2026-05-117Q13261Espacenet
JP 2026076241 A2026-05-111116Q13261Espacenet
JP 2026513839 A2026-05-01364Q13261Espacenet

1 to 10 of 425

See all 425 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
NOGAPENDEKIN ALFA INBAKICEPTCHEMBL6068330Interleukin-15 receptor agonistAGONISTChEMBL
RECOMBINANT HUMAN INTERLEUKIN-15CHEMBL4650421Interleukin-15 receptor agonistAGONISTChEMBL

Trials35

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07578558NOGAPENDEKIN ALFA INBAKICEPTPHASE2ClinicalTrials.gov
NCT07524257NOGAPENDEKIN ALFA INBAKICEPTPHASE3ClinicalTrials.gov
NCT07492888NOGAPENDEKIN ALFA INBAKICEPTPHASE2ClinicalTrials.gov
NCT07492875NOGAPENDEKIN ALFA INBAKICEPTPHASE3ClinicalTrials.gov
NCT07488884NOGAPENDEKIN ALFA INBAKICEPTPHASE1ClinicalTrials.gov
NCT07355205NOGAPENDEKIN ALFA INBAKICEPTPHASE1/PHASE2ClinicalTrials.gov
NCT07261657NOGAPENDEKIN ALFA INBAKICEPTEARLY_PHASE1ClinicalTrials.gov
NCT07217496NOGAPENDEKIN ALFA INBAKICEPTPHASE1ClinicalTrials.gov
NCT07145164RECOMBINANT HUMAN INTERLEUKIN-15PHASE2ClinicalTrials.gov
NCT06995872RECOMBINANT HUMAN INTERLEUKIN-15PHASE1ClinicalTrials.gov

1 to 10 of 35

See all 35 trials

NIH grants2,033

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIL15RA papersNewest fiscal year
P30CA008748Cancer Center Support Grant242025
P01CA111412NK cells, their receptors and cancer therapy162025
P30CA016672Cancer Center Support Grant142025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies132025
P01CA163205Circumventing Barriers to Effective Oncolytic Virotherapy of Malignant Gliomas82025
ZIABC010334Conserved Element DNA Vaccine82025
P30CA016058Cancer Center Support Grant72025
P30CA091842Cancer Center Support Grant72025
P50CA171963Specialized Program of Research Excellence (SPORE) in Leukemia72025
ZIABC010944Strategies for Cancer Immunotherapy Development: Preclinical Studies72025

1 to 10 of 2,033Source NIH's project files

See all 2,033 nih grants

Papers2,328

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
IL-15 trans-presentation at the innate-adaptive interface: mechanisms and translation in cancer immunotherapy.Oncoimmunology202642771543PubTator, text miningPubMed
Enhancing HIV-1-specific CAR-T cell functional activity by treatment with a novel cytokine-based scaffold with IL-15 superagonist and TGF-β-neutralizing activity.J Virol202642599109PubTator, text miningPubMed
The gut-immune-brain axis in CNS tumors: Causal roles of microbiota and inflammatory proteins unveiled by Mendelian randomization and single-cell transcriptomics.Medicine (Baltimore)202642566596PubTator, text miningPubMed
Causal relationship between 91 circulating inflammatory proteins and osteomyelitis risk: evidence from a Mendelian randomization study.Arch Med Sci202642540617PubTator, text miningPubMed
EBER-associated promoter contacts mark accessible but transcriptionally constrained RNAPII promoter hubs in EBV-positive B cells.Epigenetics Chromatin202642477823PubTator, text miningPubMed
Armed Oncolytic Myxoma Virus Induces Systemic Antitumor Immunity Against Solid Tumors in Immunocompetent Mice.Res Sq202642466427PubTator, text miningPubMed
Synergistic Oncolytic Effect of HSVtk- and IL-15Rα-Armed Vaccinia Viruses Inducing Systemic Antitumor Immunity.Int J Mol Sci202642450112PubTator, text miningPubMed
Serum Proteomic Profiles of Microvascular Inflammation in Donor-specific Antibody-negative and C4d-negative in Kidney Transplantation.Transplantation202642441560PubTator, text miningPubMed
Engineering with EP2/EP4 knockout and IL-15 transpresentation renders stem cell-derived NK cells self-persistent and resistant to PGE2 inhibition.Front Immunol202642433369PubTator, text miningPubMed
Natural and Engineered Cytokines as Cancer Therapeutics.Annu Rev Cancer Biol202642428769PubTator, text miningPubMed

1 to 10 of 2,328

See all 2,328 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3601

GET https://conductscience.org/api/genes/v1/3601/patents?page=2