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Gene · 3612

IMPA1: inositol monophosphatase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IMPA1: inositol monophosphatase 1. Genes, record 3612. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3612

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Gene

Symbol
IMPA1
HGNC
Name
inositol monophosphatase 1
HGNC
NCBI Gene ID
3612
NCBI Gene
HGNC ID
HGNC:6050
HGNC
Ensembl
ENSG00000133731
NCBI Gene
Aliases
IMP, IMPA, MRT59
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P29218Inositol monophosphatase 127713Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449876P29218Espacenet
EP 4650780 A22025-11-191564P29218Espacenet
JP 2025517970 A2025-06-121564P29218Espacenet
US 11446398 B22022-09-2040477P29218Espacenet
JP 2022524081 A2022-04-27143448P29218Espacenet
JP 2019054813 A2019-04-11230311P29218Espacenet
JP 2017121241 A2017-07-13230311P29218Espacenet
JP 2015516143 A2015-06-08230311P29218Espacenet
WO 2013190075 A22013-12-27753P29218Espacenet
US 8586006 B22013-11-199977P29218Espacenet

1 to 10 of 23

See all 23 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LITHIUM CARBONATECHEMBL1200826Inositol-1(or 4)-monophosphatase 1 inhibitorINHIBITORChEMBL
LITHIUM CITRATECHEMBL2103738Inositol-1(or 4)-monophosphatase 1 inhibitorINHIBITORChEMBL
LITHIUM CITRATE ANHYDROUSCHEMBL1201170Inositol-1(or 4)-monophosphatase 1 inhibitorINHIBITORChEMBL

Trials87

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07540338LITHIUM CARBONATEPHASE1/PHASE2ClinicalTrials.gov
NCT06789783LITHIUM CARBONATEPHASE2/PHASE3ClinicalTrials.gov
NCT06424613LITHIUM CARBONATEClinicalTrials.gov
NCT06184581LITHIUM CARBONATEPHASE4ClinicalTrials.gov
NCT06008249LITHIUM CARBONATEPHASE3ClinicalTrials.gov
NCT05973786LITHIUM CARBONATEPHASE3ClinicalTrials.gov
NCT05923476LITHIUM CARBONATEEARLY_PHASE1ClinicalTrials.gov
NCT05913947LITHIUM CARBONATEPHASE4ClinicalTrials.gov
NCT05814640LITHIUM CARBONATEPHASE1/PHASE2ClinicalTrials.gov
NCT05618587LITHIUM CARBONATEPHASE22025-03-05ClinicalTrials.gov

1 to 10 of 87

See all 87 trials

NIH grants869

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIMPA1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant52025
P01AI120943Molecular Mechanisms of Filoviral-host Interactions42025
P30CA056036Translational Research in Cancer42025
P30DK058404Molecular and Cellular Basis for Digestive Diseases42025
R01AI072219Understanding B-Lactam Resistance in Acinetobacter baumannii42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA016672Cancer Center Support Grant32025
P30CA021765Cancer Center Support Grant (CCSG)32025
P30CA068485Cancer Center Support Grant32025
R35GM140733Mechanism of Viral Genome Delivery into Cells32025

1 to 10 of 869Source NIH's project files

See all 869 nih grants

Papers1,792

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Alternative bipartite arrangements of VP1 BR1-3 drive efficient nuclear import of AAV2 capsids.J Biol Chem202642749258PubTator, text miningPubMed
Prevalence and clinical outcomes of Carbapenemase-Producing Enterobacterales (CPE) colonization in patients with solid organ malignancies: a prospective study.Eur J Clin Microbiol Infect Dis202642711638PubTator, text miningPubMed
Characterization of resistance to last-line therapeutic molecules and genetic diversity of Klebsiella spp. strains involved in urinary tract infections in women: the case of Hôpital d'Instruction des Armées Omar Bongo Ondimba.
J Med Microbiol202642658193PubTator, text miningPubMed
Rice Orange Leaf Phytoplasma Imp Protein Blocks G-M Interaction by Binding Glycoprotein G to Suppress Rice Stripe Mosaic Virus Infection.Plant Cell Environ202642634277PubTator, text miningPubMed
PlasmidRiskNet: An explainable machine-learning framework for antimicrobial resistance plasmid risk stratification.New Microbes New Infect202642597927PubTator, text miningPubMed
Teaching IMP (Impact, Meaning, Priorities): supporting meaningful psychosocial exploration and tailored management planning in GP training.Educ Prim Care202642444034PubTator, text miningPubMed
Corrigendum to "Nitazoxanide reverses pulmonary vascular remodeling in pulmonary hypertension by targeting the IMPA1-RAGE signaling axis" [Toxicology and Applied Pharmacology 507 (2026) 117657].Toxicol Appl Pharmacol202642392274PubTator, text miningPubMed
Systematic surveillance of Carbapenemase-producing Enterobacterales reveals persistent spread of IMP-4 IncM2 plasmids in New Caledonia.Commun Med (Lond)202642373753PubTator, text miningPubMed
Identification of IMP-8-carrying Comamonas thiooxydans strains from a diarrheal sample: genomic insights into plasmid-borne carbapenemase in an environmental bacterium.BMC Genomics202642363049PubTator, text miningPubMed
Carbapenem-resistant Enterobacterales across the UK: A nationwide study of carbapenemase testing and novel antimicrobial activity.Int J Antimicrob Agents202642362072PubTator, text miningPubMed

1 to 10 of 1,792

See all 1,792 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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