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Gene · 3658

IREB2: iron responsive element binding protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IREB2: iron responsive element binding protein 2. Genes, record 3658. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3658

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Gene

Symbol
IREB2
HGNC
Name
iron responsive element binding protein 2
HGNC
NCBI Gene ID
3658
NCBI Gene
HGNC ID
HGNC:6115
HGNC
Ensembl
ENSG00000136381
NCBI Gene
Aliases
ACO3, IRE-BP 2, IRE-BP2, IRP2, IRP2AD, NDCAMA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48200Iron-responsive element-binding protein 29631Ensembl, GeneID, HGNC

Source UniProt

Patents7

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-191719P48200Espacenet
JP 2025517970 A2025-06-121719P48200Espacenet
JP 2022546675 A2022-11-072P48200Espacenet
US 11446398 B22022-09-2042035P48200Espacenet
JP 2022524081 A2022-04-27145006P48200Espacenet
KR 1020220047639 A2022-04-182P48200Espacenet
WO 2021032779 A12021-02-252P48200Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,329

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIREB2 papersNewest fiscal year
ZIAHD001602Regulation Of Intracellular Iron Metabolism442025
ZIAHD008814Mammalian iron-sulfur cluster biogenesis212025
P30ES006694Southwest Environmental Health Sciences Center62025
P01HL114501Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers52025
P30CA086862Cancer Center Support Grant52025
P30ES025128Center for Human Health and the Environment (CHHE)52025
T32HL007427SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES52025
P30CA008748Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30CA076292Moffitt Cancer Center Support Grant42025

1 to 10 of 1,329Source NIH's project files

See all 1,329 nih grants

Papers2,039

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Statement of Retraction: MiR-19a suppresses ferroptosis of colorectal cancer cells by targeting IREB2.Bioengineered202642821367PubTator, text miningPubMed
Targeting Iron Regulatory Protein 2 in Tumor-associated Macrophages Activates Antitumor Immunity in NSCLC via Modulating SphK1-PD-L1 Axis.Int J Biol Sci202642807526PubTator, text miningPubMed
Realgar Transforming Solution Triggers Ferroptosis-Associated Death in NB4 Leukemia Cells through Disruption of Iron Homeostasis and Suppression of the SLC7A11/GPX4 Axis.Biol Pharm Bull202642716792PubTator, text miningPubMed
Chemogenomic maps reveal a PRDX1-dependent iron-damage axis in the DNA damage response.Nat Chem Biol202642711491PubTator, text miningPubMed
ADHD-anchored partitioning of non-small cell lung cancer genetic covariance identifies CLPTM1L and suggestive innate-immune signals.Front Immunol202642661613PubTator, text miningPubMed
Integrated multi-omics profiling of amniotic fluid identifies predictive biomarkers for fetal growth restriction trajectories.Ann Med202642603261PubTator, text miningPubMed
Polyamines buffer labile iron to suppress ferroptosis.Cell202642600612PubTator, text miningPubMed
EGR1 promotes ferroptosis in endometrial cancer cells by increasing NOX4 transcription.Histol Histopathol202642478614PubTator, text miningPubMed
Germline determinants of risk and molecular subtype in young-onset lung cancer.medRxiv202642465903PubTator, text miningPubMed
Iron biomarkers for prognosis, diagnosis, and therapeutic insight in colorectal cancer.Biomed Pharmacother202642442308PubTator, text miningPubMed

1 to 10 of 2,039

See all 2,039 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3658

GET https://conductscience.org/api/genes/v1/3658/grants?page=2