Gene · 3658
IREB2: iron responsive element binding protein 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IREB2: iron responsive element binding protein 2. Genes, record 3658. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3658
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P48200 | Iron-responsive element-binding protein 2 | 963 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents7
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 1719 | P48200 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1719 | P48200 | Espacenet |
| JP 2022546675 A | 2022-11-07 | 2 | P48200 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 42035 | P48200 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 145006 | P48200 | Espacenet |
| KR 1020220047639 A | 2022-04-18 | 2 | P48200 | Espacenet |
| WO 2021032779 A1 | 2021-02-25 | 2 | P48200 | Espacenet |
Drugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,329
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IREB2 papers | Newest fiscal year |
|---|---|---|---|
| ZIAHD001602 | Regulation Of Intracellular Iron Metabolism | 44 | 2025 |
| ZIAHD008814 | Mammalian iron-sulfur cluster biogenesis | 21 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 6 | 2025 |
| P01HL114501 | Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers | 5 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 5 | 2025 |
| P30ES025128 | Center for Human Health and the Environment (CHHE) | 5 | 2025 |
| T32HL007427 | SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,329Source NIH's project files
See all 1,329 nih grantsPapers2,039
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Statement of Retraction: MiR-19a suppresses ferroptosis of colorectal cancer cells by targeting IREB2. | Bioengineered | 2026 | 42821367 | PubTator, text mining | PubMed |
| Targeting Iron Regulatory Protein 2 in Tumor-associated Macrophages Activates Antitumor Immunity in NSCLC via Modulating SphK1-PD-L1 Axis. | Int J Biol Sci | 2026 | 42807526 | PubTator, text mining | PubMed |
| Realgar Transforming Solution Triggers Ferroptosis-Associated Death in NB4 Leukemia Cells through Disruption of Iron Homeostasis and Suppression of the SLC7A11/GPX4 Axis. | Biol Pharm Bull | 2026 | 42716792 | PubTator, text mining | PubMed |
| Chemogenomic maps reveal a PRDX1-dependent iron-damage axis in the DNA damage response. | Nat Chem Biol | 2026 | 42711491 | PubTator, text mining | PubMed |
| ADHD-anchored partitioning of non-small cell lung cancer genetic covariance identifies CLPTM1L and suggestive innate-immune signals. | Front Immunol | 2026 | 42661613 | PubTator, text mining | PubMed |
| Integrated multi-omics profiling of amniotic fluid identifies predictive biomarkers for fetal growth restriction trajectories. | Ann Med | 2026 | 42603261 | PubTator, text mining | PubMed |
| Polyamines buffer labile iron to suppress ferroptosis. | Cell | 2026 | 42600612 | PubTator, text mining | PubMed |
| EGR1 promotes ferroptosis in endometrial cancer cells by increasing NOX4 transcription. | Histol Histopathol | 2026 | 42478614 | PubTator, text mining | PubMed |
| Germline determinants of risk and molecular subtype in young-onset lung cancer. | medRxiv | 2026 | 42465903 | PubTator, text mining | PubMed |
| Iron biomarkers for prognosis, diagnosis, and therapeutic insight in colorectal cancer. | Biomed Pharmacother | 2026 | 42442308 | PubTator, text mining | PubMed |
1 to 10 of 2,039
See all 2,039 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3658
GET https://conductscience.org/api/genes/v1/3658/grants?page=2