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Gene · 3736

KCNA1: potassium voltage-gated channel subfamily A member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNA1: potassium voltage-gated channel subfamily A member 1. Genes, record 3736. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3736

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Gene

Symbol
KCNA1
HGNC
Name
potassium voltage-gated channel subfamily A member 1
HGNC
NCBI Gene ID
3736
NCBI Gene
HGNC ID
HGNC:6218
HGNC
Ensembl
ENSG00000111262
NCBI Gene
Aliases
AEMK, EA1, HBK1, HUK1, KV1.1, Kv1.1, MBK1, MK1, RBK1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q09470Potassium voltage-gated channel subfamily A member 14950Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458775Q09470Espacenet
JP 2026004568 A2026-01-1458776Q09470Espacenet
EP 4641201 A22025-10-2910922Q09470Espacenet
JP 2025529142 A2025-09-042187Q09470Espacenet
US 12371689 B22025-07-292187Q09470Espacenet
JP 2025517969 A2025-06-1210922Q09470Espacenet
JP 2025032204 A2025-03-1130203Q09470Espacenet
EP 4461818 A22024-11-1330203Q09470Espacenet
US 11779658 B22023-10-105Q09470Espacenet
JP 2023534452 A2023-08-0910Q09470Espacenet

1 to 10 of 31

See all 31 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL
NERISPIRDINECHEMBL2107762Voltage-gated potassium channel blockerBLOCKERChEMBL
TEDISAMILCHEMBL113461Voltage-gated potassium channel blockerBLOCKERChEMBL

Trials86

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06333171DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06294821DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06136728DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT05919407AMIFAMPRIDINEPHASE3ClinicalTrials.gov

1 to 10 of 86

See all 86 trials

NIH grants1,267

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNA1 papersNewest fiscal year
R01CA159859Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma72025
P30CA016672Cancer Center Support Grant42025
P51OD010425Washington National Primate Research Center42025
R01GM030376The Electrophysiological Studies of Voltage Gated Channels42025
R01NS029709Excitability and Plasticity of Developing Epileptic Brain42025
R01NS107671Therapeutic small molecule modulation of Kv channels42025
R35GM130377Ion Channel Transporter Interactions42025
P40OD010440Caenorhabditis Genetics Center32025
R01DC001919Expression of Ion Channels in the Auditory System32025
R01HL059949Structural Determinants of PIP2 Regulation32025

1 to 10 of 1,267Source NIH's project files

See all 1,267 nih grants

Papers2,297

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Novel KCNA1 Variant in a Patient With Tremor and Autism Spectrum Disorder Causes Mixed LOF/GOF Defects of Kv1.1 Channels.Ann Clin Transl Neurol202642768297PubTator, text miningPubMed
Targeted Sequencing and Haplotype Analysis of Voltage-Gated Potassium Channel Genes Reveal a Potential Association of KCNV2 Haplotypes with Antiseizure Medication Response in Turkish Patients with Epilepsy.
Pharmaceuticals (Basel)202642653690PubTator, text miningPubMed
A patent perspective of RSK inhibitors to treat cancer (2020-present).Expert Opin Ther Pat202642508020PubTator, text miningPubMed
Postmortem cerebellar and brainstem alterations in episodic ataxia type 1 and 2: Expanding the clinicopathological spectrum.Clin Neuropathol202642290287PubTator, text miningPubMed
Paroxysmal kinesigenic dyskinesia: clinical report of 10 cases from three pedigrees with literature review.Neurol Sci202642168455PubTator, text miningPubMed
Diagnostic approach to episodic ataxia types 1 and 2: a proposed algorithm for limited resource-settings.Front Neurol202642093925PubTator, text miningPubMed
Potassium Channelopathies and Precision Medicine Approaches in Epilepsy: A Systematic Review of Personalized Treatment Strategies.Curr Neuropharmacol202642003125PubTator, text miningPubMed
Ferroptosis in Glioblastoma and Neuroblastoma: Molecular Mechanisms and Novel Therapeutic Strategies.Curr Issues Mol Biol202641899419PubTator, text miningPubMed
Molecular Basis of the Inhibition of Voltage-Gated Potassium Channel Kv1.1 by Chinese Tarantula Peptide Huwentoxin-XI.Toxins (Basel)202641893546PubTator, text miningPubMed
A conserved bioelectrical signature defines subventricular zone-derived human fetal neural stem cells and tracks their differentiation state.Front Cell Dev Biol202641890905PubTator, text miningPubMed

1 to 10 of 2,297

See all 2,297 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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