Gene · 3737
KCNA2: potassium voltage-gated channel subfamily A member 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KCNA2: potassium voltage-gated channel subfamily A member 2. Genes, record 3737. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3737
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P16389 | Potassium voltage-gated channel subfamily A member 2 | 499 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents58
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 4543 | P16389 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2189 | P16389 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2189 | P16389 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4543 | P16389 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30206 | P16389 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30212 | P16389 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30213 | P16389 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30214 | P16389 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30215 | P16389 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 30206 | P16389 | Espacenet |
1 to 10 of 58
See all 58 patentsDrugs7
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMIFAMPRIDINE | CHEMBL354077 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| AMIFAMPRIDINE PHOSPHATE | CHEMBL3301611 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| DALFAMPRIDINE | CHEMBL284348 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| GUANIDINE | CHEMBL821 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| GUANIDINE HYDROCHLORIDE | CHEMBL1200728 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| NERISPIRDINE | CHEMBL2107762 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| TEDISAMIL | CHEMBL113461 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
Trials86
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07532460 | DALFAMPRIDINE | ClinicalTrials.gov | ||
| NCT07185347 | DALFAMPRIDINE | PHASE3 | ClinicalTrials.gov | |
| NCT07171203 | DALFAMPRIDINE | PHASE1 | ClinicalTrials.gov | |
| NCT06853015 | DALFAMPRIDINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT06751784 | DALFAMPRIDINE | PHASE2 | ClinicalTrials.gov | |
| NCT06596434 | DALFAMPRIDINE | PHASE2 | ClinicalTrials.gov | |
| NCT06333171 | DALFAMPRIDINE | PHASE2 | ClinicalTrials.gov | |
| NCT06294821 | DALFAMPRIDINE | PHASE2 | ClinicalTrials.gov | |
| NCT06136728 | DALFAMPRIDINE | PHASE3 | ClinicalTrials.gov | |
| NCT05919407 | AMIFAMPRIDINE | PHASE3 | ClinicalTrials.gov |
1 to 10 of 86
See all 86 trialsNIH grants1,113
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KCNA2 papers | Newest fiscal year |
|---|---|---|---|
| R01GM030376 | The Electrophysiological Studies of Voltage Gated Channels | 11 | 2025 |
| R01HL112808 | Structural Basis for Antiarrhythmic Drug Action | 5 | 2025 |
| T32HL086350 | Training Program in Basic and Translational Cardiovascular Science | 5 | 2025 |
| ZIANS002945 | Gating mechanisms and pharmacology of voltage-activated ion channels | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| R01HL122010 | Decrypting Variants of Uncertain Significance in Long-QT Syndrome | 4 | 2025 |
| R01NS107671 | Therapeutic small molecule modulation of Kv channels | 4 | 2025 |
| P20GM103449 | Vermont Biomedical Research Network-Vermont INBRE | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| R01ES014901 | Molecular and Cellular Basis of PCB Developmental Neurotoxicity | 3 | 2025 |
1 to 10 of 1,113Source NIH's project files
See all 1,113 nih grantsPapers1,945
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Diterpenoid alkaloids from Delphinium aemulans Nevski and their analgesic and ion channel inhibitory activities. | Phytochemistry | 2027 | 42710726 | PubTator, text mining | PubMed |
| Clinical and Genetic Analysis of Pediatric Neurodevelopmental Disorders With Complex Chromosomal Rearrangements in Two Cases. | Mol Genet Genomic Med | 2026 | 42773581 | PubTator, text mining | PubMed |
Targeted Sequencing and Haplotype Analysis of Voltage-Gated Potassium Channel Genes Reveal a Potential Association of KCNV2 Haplotypes with Antiseizure Medication Response in Turkish Patients with Epilepsy. | Pharmaceuticals (Basel) | 2026 | 42653690 | PubTator, text mining | PubMed |
| MetaOmixTools: A User-Friendly Web Suite for Meta-analysis of Ranked Features and Functional Enrichment. | Comput Struct Biotechnol J | 2026 | 42614712 | PubTator, text mining | PubMed |
| [Analysis of KCNA2 gene variant in a Chinese pedigree affected with developmental and epileptic encephalopathy]. | Zhonghua Yi Xue Yi Chuan Xue Za Zhi | 2026 | 42386661 | PubTator, text mining | PubMed |
| Enhanced calcium activity and transcriptomic alterations in iPSC-derived neurons from BAFME patients with repeat expansions. | Neurosci Res | 2026 | 42276331 | PubTator, text mining | PubMed |
| Development of Predictive Models for NB-UVB Treatment Efficacy and Safety in Psoriasis. | Psoriasis (Auckl) | 2026 | 42220473 | PubTator, text mining | PubMed |
| Genotype mutations and phenotypes of 30 cases with epilepsy related to fever sensitivity in children. | Front Neurol | 2026 | 42037703 | PubTator, text mining | PubMed |
| KCNA2 Variants in Epilepsy: Focusing on Spike-and-Wave Activation in Sleep. | Pediatr Neurol | 2026 | 42033987 | PubTator, text mining | PubMed |
| Potassium Channelopathies and Precision Medicine Approaches in Epilepsy: A Systematic Review of Personalized Treatment Strategies. | Curr Neuropharmacol | 2026 | 42003125 | PubTator, text mining | PubMed |
1 to 10 of 1,945
See all 1,945 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3737
GET https://conductscience.org/api/genes/v1/3737/patents?page=2