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Gene · 3737

KCNA2: potassium voltage-gated channel subfamily A member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNA2: potassium voltage-gated channel subfamily A member 2. Genes, record 3737. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3737

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Gene

Symbol
KCNA2
HGNC
Name
potassium voltage-gated channel subfamily A member 2
HGNC
NCBI Gene ID
3737
NCBI Gene
HGNC ID
HGNC:6220
HGNC
Ensembl
ENSG00000177301
NCBI Gene
Aliases
DEE32, EIEE32, HBK5, HK4, HUKIV, KV1.2, Kv1.2, MK2, NGK1, RBK2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P16389Potassium voltage-gated channel subfamily A member 24990Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-294543P16389Espacenet
JP 2025529142 A2025-09-042189P16389Espacenet
US 12371689 B22025-07-292189P16389Espacenet
JP 2025517969 A2025-06-124543P16389Espacenet
JP 2025032204 A2025-03-1130206P16389Espacenet
JP 2025032204 A2025-03-1130212P16389Espacenet
JP 2025032204 A2025-03-1130213P16389Espacenet
JP 2025032204 A2025-03-1130214P16389Espacenet
JP 2025032204 A2025-03-1130215P16389Espacenet
EP 4461818 A22024-11-1330206P16389Espacenet

1 to 10 of 58

See all 58 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL
NERISPIRDINECHEMBL2107762Voltage-gated potassium channel blockerBLOCKERChEMBL
TEDISAMILCHEMBL113461Voltage-gated potassium channel blockerBLOCKERChEMBL

Trials86

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06333171DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06294821DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06136728DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT05919407AMIFAMPRIDINEPHASE3ClinicalTrials.gov

1 to 10 of 86

See all 86 trials

NIH grants1,113

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNA2 papersNewest fiscal year
R01GM030376The Electrophysiological Studies of Voltage Gated Channels112025
R01HL112808Structural Basis for Antiarrhythmic Drug Action52025
T32HL086350Training Program in Basic and Translational Cardiovascular Science52025
ZIANS002945Gating mechanisms and pharmacology of voltage-activated ion channels52025
P30CA016672Cancer Center Support Grant42025
R01HL122010Decrypting Variants of Uncertain Significance in Long-QT Syndrome42025
R01NS107671Therapeutic small molecule modulation of Kv channels42025
P20GM103449Vermont Biomedical Research Network-Vermont INBRE32025
P30CA008748Cancer Center Support Grant32025
R01ES014901Molecular and Cellular Basis of PCB Developmental Neurotoxicity32025

1 to 10 of 1,113Source NIH's project files

See all 1,113 nih grants

Papers1,945

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Diterpenoid alkaloids from Delphinium aemulans Nevski and their analgesic and ion channel inhibitory activities.Phytochemistry202742710726PubTator, text miningPubMed
Clinical and Genetic Analysis of Pediatric Neurodevelopmental Disorders With Complex Chromosomal Rearrangements in Two Cases.Mol Genet Genomic Med202642773581PubTator, text miningPubMed
Targeted Sequencing and Haplotype Analysis of Voltage-Gated Potassium Channel Genes Reveal a Potential Association of KCNV2 Haplotypes with Antiseizure Medication Response in Turkish Patients with Epilepsy.
Pharmaceuticals (Basel)202642653690PubTator, text miningPubMed
MetaOmixTools: A User-Friendly Web Suite for Meta-analysis of Ranked Features and Functional Enrichment.Comput Struct Biotechnol J202642614712PubTator, text miningPubMed
[Analysis of KCNA2 gene variant in a Chinese pedigree affected with developmental and epileptic encephalopathy].Zhonghua Yi Xue Yi Chuan Xue Za Zhi202642386661PubTator, text miningPubMed
Enhanced calcium activity and transcriptomic alterations in iPSC-derived neurons from BAFME patients with repeat expansions.Neurosci Res202642276331PubTator, text miningPubMed
Development of Predictive Models for NB-UVB Treatment Efficacy and Safety in Psoriasis.Psoriasis (Auckl)202642220473PubTator, text miningPubMed
Genotype mutations and phenotypes of 30 cases with epilepsy related to fever sensitivity in children.Front Neurol202642037703PubTator, text miningPubMed
KCNA2 Variants in Epilepsy: Focusing on Spike-and-Wave Activation in Sleep.Pediatr Neurol202642033987PubTator, text miningPubMed
Potassium Channelopathies and Precision Medicine Approaches in Epilepsy: A Systematic Review of Personalized Treatment Strategies.Curr Neuropharmacol202642003125PubTator, text miningPubMed

1 to 10 of 1,945

See all 1,945 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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