ConductScience.org, home

Gene · 3738

KCNA3: potassium voltage-gated channel subfamily A member 3

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. KCNA3: potassium voltage-gated channel subfamily A member 3. Genes, record 3738. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3738

On this page

Gene

Symbol
KCNA3
HGNC
Name
potassium voltage-gated channel subfamily A member 3
HGNC
NCBI Gene ID
3738
NCBI Gene
HGNC ID
HGNC:6221
HGNC
Ensembl
ENSG00000177272
NCBI Gene
Aliases
HGK5, HLK3, HPCN3, HUKIII, KV1.3, Kv1.3, MK3, PCN3, RP11-284N8.3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22001Potassium voltage-gated channel subfamily A member 357516Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458778P22001Espacenet
EP 4641201 A22025-10-298853P22001Espacenet
JP 2025529142 A2025-09-042190P22001Espacenet
US 12371689 B22025-07-292190P22001Espacenet
JP 2025517969 A2025-06-128853P22001Espacenet
JP 2025032204 A2025-03-1130217P22001Espacenet
EP 4461818 A22024-11-1330217P22001Espacenet
JP 2023058610 A2023-04-2530217P22001Espacenet
US 11597763 B22023-03-071P22001Espacenet
US 11446398 B22022-09-2065836P22001Espacenet

1 to 10 of 28

See all 28 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL
NERISPIRDINECHEMBL2107762Voltage-gated potassium channel blockerBLOCKERChEMBL
TEDISAMILCHEMBL113461Voltage-gated potassium channel blockerBLOCKERChEMBL

Trials86

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06333171DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06294821DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06136728DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT05919407AMIFAMPRIDINEPHASE3ClinicalTrials.gov

1 to 10 of 86

See all 86 trials

NIH grants1,028

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNA3 papersNewest fiscal year
R01NS041435Mechanisms by which effector T cells modulate endogenous remyelination122025
T32DC000044Chemosensory Training Program (CTP)122025
R01DC001919Expression of Ion Channels in the Auditory System62025
P30AR070549Cincinnati Rheumatic Diseases Resource Center42025
P30CA008748Cancer Center Support Grant42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).42025
P30ES019776HERCULES: Exposome Research Center32025
R01AG075820Neuron and microglia-specific proteomic signatures of ERK mediated mechanisms of Alzheimer's disease.32025
R01GM030376The Electrophysiological Studies of Voltage Gated Channels32025

1 to 10 of 1,028Source NIH's project files

See all 1,028 nih grants

Papers2,009

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Potassium channels as an ionic checkpoint in tumor immunity.Front Pharmacol202642787526PubTator, text miningPubMed
Piezo1 agonists are potent off-target inhibitors of the Kv1.3 channel via gating modification.Mol Pharmacol202642691696PubTator, text miningPubMed
Nanobody regulation of C-type inactivation in Kv1.3 channels.Nat Commun202642680746PubTator, text miningPubMed
KCNA3 Gene Polymorphism Affects the Efficacy and Plasma Concentration of Perampanel in Patients With Refractory Epilepsy.Ther Drug Monit202642593405PubTator, text miningPubMed
Psoriasis-Obesity-Related Gene COX7C Promotes Keratinocyte Proliferation and Positively Regulates Inflammatory Responses in Psoriasis.J Cell Mol Med202642487278PubTator, text miningPubMed
Comparative Interactome Analysis Reveals Architectural Principles Governing K+ Channel Function in Cancer.Int J Mol Sci202642450133PubTator, text miningPubMed
Integrated Screening Cascades for Ion-Channel Drug Discovery: Linking Structure, Electrophysiology, Safety Pharmacology, and Human-Relevant Models.Int J Mol Sci202642450047PubTator, text miningPubMed
Identification and validation of aging-related genes in patients with multiple myeloma.Oncol Lett202642433653PubTator, text miningPubMed
Kv1.3 modulates macrophage M2 polarization via the STAT3 pathway: A novel mechanism and therapeutic target for steroid-resistant asthma.Transl Res202642341914PubTator, text miningPubMed
Adaptor-mediated interaction between Kv1.3 and Nedd4-2 E3 ubiquitin ligase.Commun Biol202642337377PubTator, text miningPubMed

1 to 10 of 2,009

See all 2,009 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3738

GET https://conductscience.org/api/genes/v1/3738/patents?page=2