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Gene · 3739

KCNA4: potassium voltage-gated channel subfamily A member 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNA4: potassium voltage-gated channel subfamily A member 4. Genes, record 3739. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3739

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Gene

Symbol
KCNA4
HGNC
Name
potassium voltage-gated channel subfamily A member 4
HGNC
NCBI Gene ID
3739
NCBI Gene
HGNC ID
HGNC:6222
HGNC
Ensembl
ENSG00000182255
NCBI Gene
Aliases
HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, Kv1.4, MCIDDS, PCN2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22459Potassium voltage-gated channel subfamily A member 46530Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458779P22459Espacenet
EP 4670794 A22025-12-3139P22459Espacenet
EP 4641201 A22025-10-295445P22459Espacenet
JP 2025529142 A2025-09-042191P22459Espacenet
US 12371689 B22025-07-292191P22459Espacenet
JP 2025517969 A2025-06-125445P22459Espacenet
JP 2025032204 A2025-03-1130218P22459Espacenet
EP 4461818 A22024-11-1330218P22459Espacenet
US 12011480 B22024-06-1839P22459Espacenet
JP 2023058610 A2023-04-2530218P22459Espacenet

1 to 10 of 33

See all 33 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL
NERISPIRDINECHEMBL2107762Voltage-gated potassium channel blockerBLOCKERChEMBL
TEDISAMILCHEMBL113461Voltage-gated potassium channel blockerBLOCKERChEMBL

Trials86

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06333171DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06294821DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06136728DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT05919407AMIFAMPRIDINEPHASE3ClinicalTrials.gov

1 to 10 of 86

See all 86 trials

NIH grants722

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNA4 papersNewest fiscal year
UL1TR001863Yale Clinical and Translational Science Award32025
ZIADA000206Biological And Biochemical Characterization Of Sigma Receptors32025
P30EY014801Miami Center for Vision Research22025
R01AI114780Mechanisms of autoimmunity in myasthenia gravis22025
R01HL085844Functional interactions of cardiac ion channels22025
T32DC000044Chemosensory Training Program (CTP)22025
T32HL007081Principles in Cardiovascular Research Training Program22025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).22025
UL1TR002345Washington University Institute of Clinical and Translational Sciences22025
DP1DK130673Charting human islet maturation via combined soft nanoelectronics and single-cell spatial transcriptomics12025

1 to 10 of 722Source NIH's project files

See all 722 nih grants

Papers1,050

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Autoantibody Profiles of Immune Checkpoint Inhibitor-Associated Myasthenia and Myositis.Cancer Control202642810719PubTator, text miningPubMed
Anti-striated muscle antibody positive anti-PD-1 antibody related myositis and cardiomyositis: an instructive autopsy case report with discussion for trigger of irAE.Immunol Med202642311137PubTator, text miningPubMed
Differential negative dominance by KCNA2 variants associated with global developmental delay suggests KCNA2 haploinsufficiency in humans.J Physiol202641914769PubTator, text miningPubMed
Accessibility at a primed distal Fshb-Kcna4 super-enhancer is facilitated by Foxl2 during gonadotrope differentiation.Endocrinology202641823422PubTator, text miningPubMed
Endocardial Ito-slow Overexpression and Fibrotic Remodeling Underlying Pause-Dependent Early Repolarization in Humans.JACC Clin Electrophysiol202641758094PubTator, text miningPubMed
Biomimetic electrospun scaffolds for engineered heart tissue: from design parameters to drug testing platforms.Front Bioeng Biotechnol202641743838PubTator, text miningPubMed
Case Report: Thymoma-associated myasthenia gravis, myositis, myocarditis, and anti-GAD65 autoimmune encephalitis: a unique case of paraneoplastic polyautoimmunity.Front Immunol202641743715PubTator, text miningPubMed
Contemporary Perspectives on J-Wave Syndromes: An Expert Consensus Statement.J Arrhythm202641738055PubTator, text miningPubMed
Genomic insights into substance use and disinhibitory disorders.medRxiv202641728329PubTator, text miningPubMed
Extracellular acidity and ATP modulate ion currents in human cumulus cells indicating possible roles as metabolic sensors of the follicular microenvironment.Physiol Rep202641603488PubTator, text miningPubMed

1 to 10 of 1,050

See all 1,050 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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