Gene · 3739
KCNA4: potassium voltage-gated channel subfamily A member 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KCNA4: potassium voltage-gated channel subfamily A member 4. Genes, record 3739. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3739
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P22459 | Potassium voltage-gated channel subfamily A member 4 | 653 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents33
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58779 | P22459 | Espacenet |
| EP 4670794 A2 | 2025-12-31 | 39 | P22459 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5445 | P22459 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2191 | P22459 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2191 | P22459 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5445 | P22459 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30218 | P22459 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 30218 | P22459 | Espacenet |
| US 12011480 B2 | 2024-06-18 | 39 | P22459 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 30218 | P22459 | Espacenet |
1 to 10 of 33
See all 33 patentsDrugs7
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMIFAMPRIDINE | CHEMBL354077 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| AMIFAMPRIDINE PHOSPHATE | CHEMBL3301611 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| DALFAMPRIDINE | CHEMBL284348 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| GUANIDINE | CHEMBL821 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| GUANIDINE HYDROCHLORIDE | CHEMBL1200728 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| NERISPIRDINE | CHEMBL2107762 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| TEDISAMIL | CHEMBL113461 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
Trials86
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07532460 | DALFAMPRIDINE | ClinicalTrials.gov | ||
| NCT07185347 | DALFAMPRIDINE | PHASE3 | ClinicalTrials.gov | |
| NCT07171203 | DALFAMPRIDINE | PHASE1 | ClinicalTrials.gov | |
| NCT06853015 | DALFAMPRIDINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT06751784 | DALFAMPRIDINE | PHASE2 | ClinicalTrials.gov | |
| NCT06596434 | DALFAMPRIDINE | PHASE2 | ClinicalTrials.gov | |
| NCT06333171 | DALFAMPRIDINE | PHASE2 | ClinicalTrials.gov | |
| NCT06294821 | DALFAMPRIDINE | PHASE2 | ClinicalTrials.gov | |
| NCT06136728 | DALFAMPRIDINE | PHASE3 | ClinicalTrials.gov | |
| NCT05919407 | AMIFAMPRIDINE | PHASE3 | ClinicalTrials.gov |
1 to 10 of 86
See all 86 trialsNIH grants722
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KCNA4 papers | Newest fiscal year |
|---|---|---|---|
| UL1TR001863 | Yale Clinical and Translational Science Award | 3 | 2025 |
| ZIADA000206 | Biological And Biochemical Characterization Of Sigma Receptors | 3 | 2025 |
| P30EY014801 | Miami Center for Vision Research | 2 | 2025 |
| R01AI114780 | Mechanisms of autoimmunity in myasthenia gravis | 2 | 2025 |
| R01HL085844 | Functional interactions of cardiac ion channels | 2 | 2025 |
| T32DC000044 | Chemosensory Training Program (CTP) | 2 | 2025 |
| T32HL007081 | Principles in Cardiovascular Research Training Program | 2 | 2025 |
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 2 | 2025 |
| UL1TR002345 | Washington University Institute of Clinical and Translational Sciences | 2 | 2025 |
| DP1DK130673 | Charting human islet maturation via combined soft nanoelectronics and single-cell spatial transcriptomics | 1 | 2025 |
1 to 10 of 722Source NIH's project files
See all 722 nih grantsPapers1,050
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Autoantibody Profiles of Immune Checkpoint Inhibitor-Associated Myasthenia and Myositis. | Cancer Control | 2026 | 42810719 | PubTator, text mining | PubMed |
| Anti-striated muscle antibody positive anti-PD-1 antibody related myositis and cardiomyositis: an instructive autopsy case report with discussion for trigger of irAE. | Immunol Med | 2026 | 42311137 | PubTator, text mining | PubMed |
| Differential negative dominance by KCNA2 variants associated with global developmental delay suggests KCNA2 haploinsufficiency in humans. | J Physiol | 2026 | 41914769 | PubTator, text mining | PubMed |
| Accessibility at a primed distal Fshb-Kcna4 super-enhancer is facilitated by Foxl2 during gonadotrope differentiation. | Endocrinology | 2026 | 41823422 | PubTator, text mining | PubMed |
| Endocardial Ito-slow Overexpression and Fibrotic Remodeling Underlying Pause-Dependent Early Repolarization in Humans. | JACC Clin Electrophysiol | 2026 | 41758094 | PubTator, text mining | PubMed |
| Biomimetic electrospun scaffolds for engineered heart tissue: from design parameters to drug testing platforms. | Front Bioeng Biotechnol | 2026 | 41743838 | PubTator, text mining | PubMed |
| Case Report: Thymoma-associated myasthenia gravis, myositis, myocarditis, and anti-GAD65 autoimmune encephalitis: a unique case of paraneoplastic polyautoimmunity. | Front Immunol | 2026 | 41743715 | PubTator, text mining | PubMed |
| Contemporary Perspectives on J-Wave Syndromes: An Expert Consensus Statement. | J Arrhythm | 2026 | 41738055 | PubTator, text mining | PubMed |
| Genomic insights into substance use and disinhibitory disorders. | medRxiv | 2026 | 41728329 | PubTator, text mining | PubMed |
| Extracellular acidity and ATP modulate ion currents in human cumulus cells indicating possible roles as metabolic sensors of the follicular microenvironment. | Physiol Rep | 2026 | 41603488 | PubTator, text mining | PubMed |
1 to 10 of 1,050
See all 1,050 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3739
GET https://conductscience.org/api/genes/v1/3739/patents?page=2