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Gene · 3741

KCNA5: potassium voltage-gated channel subfamily A member 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNA5: potassium voltage-gated channel subfamily A member 5. Genes, record 3741. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3741

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Gene

Symbol
KCNA5
HGNC
Name
potassium voltage-gated channel subfamily A member 5
HGNC
NCBI Gene ID
3741
NCBI Gene
HGNC ID
HGNC:6224
HGNC
Ensembl
ENSG00000130037
NCBI Gene
Aliases
ATFB7, HCK1, HK2, HPCN1, KV1.5, Kv1.5, PCN1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22460Potassium voltage-gated channel subfamily A member 56130Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458780P22460Espacenet
EP 4641201 A22025-10-291016P22460Espacenet
JP 2025529142 A2025-09-042192P22460Espacenet
US 12371689 B22025-07-292192P22460Espacenet
JP 2025517969 A2025-06-121016P22460Espacenet
US 11446398 B22022-09-2065838P22460Espacenet
US 11400116 B22022-08-022590P22460Espacenet
JP 2022524081 A2022-04-27168809P22460Espacenet
US 11078247 B22021-08-035711P22460Espacenet
US 10753947 B22020-08-2525P22460Espacenet

1 to 10 of 24

See all 24 patents

Drugs9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL
NERISPIRDINECHEMBL2107762Voltage-gated potassium channel blockerBLOCKERChEMBL
TEDISAMILCHEMBL113461Voltage-gated potassium channel blockerBLOCKERChEMBL
VERNAKALANTCHEMBL2111112Voltage-gated potassium channel subunit Kv1.5 blockerBLOCKERChEMBL
VERNAKALANT HYDROCHLORIDECHEMBL2107383Voltage-gated potassium channel subunit Kv1.5 blockerBLOCKERChEMBL

Trials96

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06333171DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06294821DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06136728DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT05919407AMIFAMPRIDINEPHASE3ClinicalTrials.gov

1 to 10 of 96

See all 96 trials

NIH grants1,163

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNA5 papersNewest fiscal year
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation82025
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL72025
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology52025
P40OD010440Caenorhabditis Genetics Center42025
T32HL086350Training Program in Basic and Translational Cardiovascular Science42025
R01GM030376The Electrophysiological Studies of Voltage Gated Channels32025
R01HL111600Sympathetic remodeling and ventricular arrhythmia32025
R01HL141214Functional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac Remodeling32025
R01HL142282CaMKII activation and regulation in adult cardiac myocytes32025
T32DC000011Sensory Mechanisms and Disorders32025

1 to 10 of 1,163Source NIH's project files

See all 1,163 nih grants

Papers2,161

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Selective inhibition of LY294002 across cloned human cardiac ion channels: implications for atrium-selective therapy in atrial fibrillation.Front Pharmacol202642780784PubTator, text miningPubMed
Modulation of voltage-dependent K+ channel activity by the muscarinic receptor antagonist solifenacin in native coronary arterial smooth muscle cells.Korean J Physiol Pharmacol202642733228PubTator, text miningPubMed
Ion-Channel Activity of Characteristic Alkaloids From Uncaria rhynchophylla.Chem Biodivers202642720106PubTator, text miningPubMed
A designer pore-blocking peptide reveals an electrostatic complementation mechanism for the inhibition-resistant Kv1.5 channel.Sci Adv202642696590PubTator, text miningPubMed
Electrophysiological Characterization of MK886-Mediated Suppression of Voltage-Gated K+ Currents in Rabbit Coronary Artery Smooth Muscle Cells.J Appl Toxicol202642487466PubTator, text miningPubMed
The Genetics of Atrial Fibrillation: From Molecular Mechanisms to Precision Medicine.Cureus202642371450PubTator, text miningPubMed
Integrative network toxicology and single-cell analysis implicates a potential TGFBR1-centered fibroblast remodeling axis in Benzo[a]pyrene-related atrial fibrillation.Environ Int202642364542PubTator, text miningPubMed
Molecular-Genetic Basis of Pulmonary Arterial Hypertension (PAH).Curr Issues Mol Biol202642353577PubTator, text miningPubMed
The interplay between dynamic regulation of ion-channel gating and trafficking in cardiac arrhythmogenesis.J Physiol202642330017PubTator, text miningPubMed
Functional characterisation of KCNA5 gene variants linked to pulmonary arterial hypertension.Eur Respir J202642315184PubTator, text miningPubMed

1 to 10 of 2,161

See all 2,161 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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