Gene · 3744
KCNA10: potassium voltage-gated channel subfamily A member 10
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KCNA10: potassium voltage-gated channel subfamily A member 10. Genes, record 3744. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3744
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16322 | Potassium voltage-gated channel subfamily A member 10 | 511 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents16
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58777 | Q16322 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8855 | Q16322 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2188 | Q16322 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2188 | Q16322 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8855 | Q16322 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 65831 | Q16322 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3314 | Q16322 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 168802 | Q16322 | Espacenet |
| US 10753947 B2 | 2020-08-25 | 28 | Q16322 | Espacenet |
| US 10739354 B2 | 2020-08-11 | 28 | Q16322 | Espacenet |
1 to 10 of 16
See all 16 patentsDrugs7
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMIFAMPRIDINE | CHEMBL354077 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| AMIFAMPRIDINE PHOSPHATE | CHEMBL3301611 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| DALFAMPRIDINE | CHEMBL284348 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| GUANIDINE | CHEMBL821 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| GUANIDINE HYDROCHLORIDE | CHEMBL1200728 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| NERISPIRDINE | CHEMBL2107762 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
| TEDISAMIL | CHEMBL113461 | Voltage-gated potassium channel blocker | BLOCKER | ChEMBL |
Trials86
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07532460 | DALFAMPRIDINE | ClinicalTrials.gov | ||
| NCT07185347 | DALFAMPRIDINE | PHASE3 | ClinicalTrials.gov | |
| NCT07171203 | DALFAMPRIDINE | PHASE1 | ClinicalTrials.gov | |
| NCT06853015 | DALFAMPRIDINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT06751784 | DALFAMPRIDINE | PHASE2 | ClinicalTrials.gov | |
| NCT06596434 | DALFAMPRIDINE | PHASE2 | ClinicalTrials.gov | |
| NCT06333171 | DALFAMPRIDINE | PHASE2 | ClinicalTrials.gov | |
| NCT06294821 | DALFAMPRIDINE | PHASE2 | ClinicalTrials.gov | |
| NCT06136728 | DALFAMPRIDINE | PHASE3 | ClinicalTrials.gov | |
| NCT05919407 | AMIFAMPRIDINE | PHASE3 | ClinicalTrials.gov |
1 to 10 of 86
See all 86 trialsNIH grants129
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KCNA10 papers | Newest fiscal year |
|---|---|---|---|
| K01HL166705 | Linking endotype and phenotype to understand COPD heterogeneity via deep learning and network science | 1 | 2025 |
| K01HL169756 | Integrating multi-omics data to understand asthma heterogeneity and endotypes | 1 | 2025 |
| K08HL159318 | Multi-omic Risk Prediction of Chronic Obstructive Pulmonary Disease in European- and African-Ancestry Populations | 1 | 2025 |
| K24HL133373 | Discovery, Implementation and Mentorship in Personalized Cardiovascular Pharmacotherapy | 1 | 2025 |
| P01HL114501 | Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers | 1 | 2025 |
| P20GM103449 | Vermont Biomedical Research Network-Vermont INBRE | 1 | 2025 |
| P30CA043703 | Case Comprehensive Cancer Center Support Grant | 1 | 2025 |
| P30CA138292 | Winship Cancer Institute Cancer Center Support Grant | 1 | 2025 |
| R00HL159234 | Methylomic and metabolomic determinants of Lung Function in Asthmatics | 1 | 2025 |
| R01DC003687 | Understanding Cochlear Amplification and Otoacoustic Emissions | 1 | 2025 |
1 to 10 of 129Source NIH's project files
See all 129 nih grantsPapers141
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Multiscale Integration of Acceleration and Jerk Sensing in the Vestibular System. | Audiol Res | 2026 | 41718338 | PubTator, text mining | PubMed |
| RFC1 Repeat Expansion in Chronic Cough: Findings From the Korean Chronic Cough Registry. | Allergy Asthma Immunol Res | 2026 | 41592538 | PubTator, text mining | PubMed |
| Early downregulation of hair cell (HC)-specific genes in the vestibular sensory epithelium during chronic ototoxicity. | J Biomed Sci | 2025 | 40908485 | PubTator, text mining | PubMed |
| Elucidating the role of LGALS3BP in coronary atherosclerosis: integrating bioinformatics and machine learning for advanced insights. | J Cardiothorac Surg | 2025 | 40814096 | PubTator, text mining | PubMed |
| Genomics of chronic dry cough unravels neurological pathways. | Eur Respir J | 2025 | 40675770 | PubTator, text mining | PubMed |
| The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells. | Elife | 2024 | 39625061 | PubTator, text mining | PubMed |
| Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals. | Nat Commun | 2024 | 38956042 | PubTator, text mining | PubMed |
| How AlphaFold2 shaped the structural coverage of the human transmembrane proteome. | Sci Rep | 2023 | 37985809 | PubTator, text mining | PubMed |
| Human skeletal muscle tissue chip autonomous payload reveals changes in fiber type and metabolic gene expression due to spaceflight. | NPJ Microgravity | 2023 | 37714852 | PubTator, text mining | PubMed |
| Of Seven New K+ Channel Inhibitor Peptides of Centruroides bonito, α-KTx 2.24 Has a Picomolar Affinity for Kv1.2. | Toxins (Basel) | 2023 | 37624263 | PubTator, text mining | PubMed |
1 to 10 of 141
See all 141 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3744
GET https://conductscience.org/api/genes/v1/3744/patents