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Gene · 3744

KCNA10: potassium voltage-gated channel subfamily A member 10

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNA10: potassium voltage-gated channel subfamily A member 10. Genes, record 3744. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3744

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Gene

Symbol
KCNA10
HGNC
Name
potassium voltage-gated channel subfamily A member 10
HGNC
NCBI Gene ID
3744
NCBI Gene
HGNC ID
HGNC:6219
HGNC
Ensembl
ENSG00000143105
NCBI Gene
Aliases
Kcn1, Kv1.8
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16322Potassium voltage-gated channel subfamily A member 105110Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458777Q16322Espacenet
EP 4641201 A22025-10-298855Q16322Espacenet
JP 2025529142 A2025-09-042188Q16322Espacenet
US 12371689 B22025-07-292188Q16322Espacenet
JP 2025517969 A2025-06-128855Q16322Espacenet
US 11446398 B22022-09-2065831Q16322Espacenet
US 11400116 B22022-08-023314Q16322Espacenet
JP 2022524081 A2022-04-27168802Q16322Espacenet
US 10753947 B22020-08-2528Q16322Espacenet
US 10739354 B22020-08-1128Q16322Espacenet

1 to 10 of 16

See all 16 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL
NERISPIRDINECHEMBL2107762Voltage-gated potassium channel blockerBLOCKERChEMBL
TEDISAMILCHEMBL113461Voltage-gated potassium channel blockerBLOCKERChEMBL

Trials86

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06333171DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06294821DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06136728DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT05919407AMIFAMPRIDINEPHASE3ClinicalTrials.gov

1 to 10 of 86

See all 86 trials

NIH grants129

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNA10 papersNewest fiscal year
K01HL166705Linking endotype and phenotype to understand COPD heterogeneity via deep learning and network science12025
K01HL169756Integrating multi-omics data to understand asthma heterogeneity and endotypes12025
K08HL159318Multi-omic Risk Prediction of Chronic Obstructive Pulmonary Disease in European- and African-Ancestry Populations12025
K24HL133373Discovery, Implementation and Mentorship in Personalized Cardiovascular Pharmacotherapy12025
P01HL114501Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers12025
P20GM103449Vermont Biomedical Research Network-Vermont INBRE12025
P30CA043703Case Comprehensive Cancer Center Support Grant12025
P30CA138292Winship Cancer Institute Cancer Center Support Grant12025
R00HL159234Methylomic and metabolomic determinants of Lung Function in Asthmatics12025
R01DC003687Understanding Cochlear Amplification and Otoacoustic Emissions12025

1 to 10 of 129Source NIH's project files

See all 129 nih grants

Papers141

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multiscale Integration of Acceleration and Jerk Sensing in the Vestibular System.Audiol Res202641718338PubTator, text miningPubMed
RFC1 Repeat Expansion in Chronic Cough: Findings From the Korean Chronic Cough Registry.Allergy Asthma Immunol Res202641592538PubTator, text miningPubMed
Early downregulation of hair cell (HC)-specific genes in the vestibular sensory epithelium during chronic ototoxicity.J Biomed Sci202540908485PubTator, text miningPubMed
Elucidating the role of LGALS3BP in coronary atherosclerosis: integrating bioinformatics and machine learning for advanced insights.J Cardiothorac Surg202540814096PubTator, text miningPubMed
Genomics of chronic dry cough unravels neurological pathways.Eur Respir J202540675770PubTator, text miningPubMed
The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells.Elife202439625061PubTator, text miningPubMed
Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals.Nat Commun202438956042PubTator, text miningPubMed
How AlphaFold2 shaped the structural coverage of the human transmembrane proteome.Sci Rep202337985809PubTator, text miningPubMed
Human skeletal muscle tissue chip autonomous payload reveals changes in fiber type and metabolic gene expression due to spaceflight.NPJ Microgravity202337714852PubTator, text miningPubMed
Of Seven New K+ Channel Inhibitor Peptides of Centruroides bonito, α-KTx 2.24 Has a Picomolar Affinity for Kv1.2.Toxins (Basel)202337624263PubTator, text miningPubMed

1 to 10 of 141

See all 141 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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